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公开(公告)号：EP3012321A4
公开(公告)日：2016-09-28
申请号：EP14880388
申请日：2014-11-20
发明人： CHO YEE SOOK , SON MI YOUNG , KWAK JAE EUN , SEOL BINNA , JEON HYE JIN
IPC分类号： C12N5/074 , A61K38/55 , A61P21/00 , C07K5/02 , C07K5/087 , C07K14/47 , C12N5/073 , C12N5/077 , C12N5/079 , C12N5/0793
CPC分类号： C07K14/4703 , A61K38/55 , C07K5/0202 , C07K5/0812 , C12N5/0619 , C12N5/0656 , C12N5/0696 , C12N2501/2301 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/999 , C12N2506/1307 , C12N2506/45 , C12N2510/00 , G01N33/5023
摘要： The present invention relates to a method for preparing a GM1 gangliosidosis human cell model based on induced pluripotent stem cells (iPSCs) and iPSCs originated neural progenitor cells, and a use of the GM1 model above for the development of a GM1 gangliosidosis treating agent. The iPSCs originated from GM1 patient fibroblasts can be differentiated into neural progenitor cells (NPCs) and neurosphere cells that can emulate the characteristics shown in GM1 patient, so that the said cells can be efficiently used for the investigation of intracellular GM1 symptoms such as the GM1 gangliosidosis and lysosome accumulation and the gene expression pattern change. So, the GM1 cell model of the present invention can be efficiently used for the study of GM1 development mechanism and the study for the development of a therapeutic agent for the disease. The present inventors also established the inflammasome inhibitor rhIL1RA or Z-YVAD-FMK by using the above GM1 cell model and further confirmed that it can be efficiently used as a relieving/treating agent of GM1 gangliosidosis. In addition, the molecular symptoms of GM1 patient could be reproduced in the transformed cells having the E186A mutation which is newly identified as the GM1 gangliosidosis causing protein mutation. Therefore, the mutant cells containing the induced E186A mutation can be efficiently used as the GM1 gangliosidosis cell model.
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2.发明公开COMPOSITIONS COMPRISING A MITOFUSIN INHIBITOR FOR PROMOTING CELL REPROGRAMMING AND A USE THEREOF 审中-公开WITH A MITOFUSININHIBITOR组合物，促进细胞编程及其使用
公开(公告)号：EP3041928A4
公开(公告)日：2016-08-17
申请号：EP15721111
申请日：2015-04-23
发明人： CHO YEE SOOK , SON MYUNG JIN , KWON YOU JEONG
CPC分类号： C12N5/0696 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2500/02 , C12N2501/65 , C12N2501/73 , C12N2501/998 , C12N2506/02 , C12N2510/00 , C12Y306/05
摘要： The present invention relates to a composition comprising a repressor of mitofusin gene expression, an inhibitor of mitofusin protein activity, or a mixture thereof as an active ingredient for promoting reprogramming a differentiated cell into a pluripotent stem cell, and a use thereof. The composition according to the present invention increases the efficiency of reprogramming as well as reduces the time required for reprogramming to produce pluripotent stem cells. Therefore, the present composition can be beneficially used to develop the production technology of high efficiency pluripotent stem cell and secure a large-scale culture system. Further, the present composition can be beneficially used to maintain pluripotent stem cells and screen the compounds capable of promoting the reprogramming into pluripotent stem cells.
摘要翻译： 本发明涉及一种组合物在线粒体融合蛋白蛋白活性的抑制剂，其包含基因表达线粒体融合蛋白的阻抑物，或在电视节目预告婷重编程分化的细胞为多能干细胞的混合物作为活性成分，以及它们的用途。 该组合物gemäß到本发明提高重编程的效率以及降低生产多能干细胞重编程所需的时间。 因此，本发明组合物可有利地用于开发高效率的多能干细胞的生产技术和固定大规模培养系统。此外，本发明组合物可有利地用于维持多能干细胞和筛选能够促销廷的化合物 重编程为多能干细胞。
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3.发明公开
公开(公告)号：EP2774918A4
公开(公告)日：2015-07-01
申请号：EP12877706
申请日：2012-11-08
发明人： CHO YEE SOOK , LEE KYEONG , LEE JUNG WOON
IPC分类号： C07D209/20 , C12N5/02 , C12N5/0735
CPC分类号： C12N5/0696 , C07D209/18 , C07D209/20 , C07D209/24 , C07D405/12 , C12N5/0606 , C12N2500/02 , C12N2500/30 , C12N2501/115 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/999 , C12N2506/02 , C12N2506/09
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4.发明公开WATER-SOLUBLE FLUORESCENT FULLERENE DERIVATIVE, AND PREPARATION METHOD THEREOF 有权溶于水，荧光FULLER衍生物及其制造方法
公开(公告)号：EP2565248A4
公开(公告)日：2014-04-16
申请号：EP11775226
申请日：2011-04-25
发明人： CHUNG BONG HYUN , JEONG JIN YOUNG
CPC分类号： C07C41/06 , B82Y30/00 , C07C2604/00 , C09K11/06 , C09K2211/1011 , Y10S977/74 , Y10S977/847 , C07C43/196
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5.发明公开POROUS POLYMER PARTICLES IMMOBILIZED WITH CHARGED MOLECULES AND METHOD FOR PREPARING THE SAME 审中-公开多孔聚合物颗粒具有产生电荷的分子和方法固定化
公开(公告)号：EP2176321A4
公开(公告)日：2012-09-12
申请号：EP08793054
申请日：2008-08-05
发明人： CHUNG BONG HYUN , LIM YONG TAIK , HAN JUNG HYUN
IPC分类号： C08J3/12 , A61K9/50 , A61K31/765 , A61K47/34 , A61K49/00
CPC分类号： A61K9/5031 , A61K49/0034 , A61K49/0054 , A61K49/0056 , A61K49/0089 , C08J3/12 , C08J2367/04
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6.发明公开NOVEL CINNAMALDEHYDE DERIVATIVES HAVING IMPROVED SOLUBILITY IN WATER, A METHOD FOR PREPARING THE SAME, A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND A TREATMENT METHOD OF CANCER USING THE SAME 有权具有改进的溶解度新水肉桂醛，在制造所述药物组合物这包含，和方法治疗癌症的方法从这些衍生工具是必需的
公开(公告)号：EP2303823A4
公开(公告)日：2012-07-18
申请号：EP08874814
申请日：2008-12-04
发明人： KWON BYOUNG MOG , HAN DONG CHOI , KIM HYE NAN , HAN YOUNG MIN , SHIN DAE SEOP , KANG YEONG RIM
IPC分类号： C07C47/228 , A61K31/4402 , A61P35/00 , C07D213/79
CPC分类号： C07C309/73 , C07C69/708 , C07D213/79
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7.发明公开FULLERENE-SILICA NANOPARTICLES WITH IMPROVED FLUORESCENCE, PREPARATION METHOD THEREOF AND USE THEREOF 有权具有改进的荧光，流程以对其及其应用FULLEREN - 二氧化硅纳米粒子
公开(公告)号：EP2295374A4
公开(公告)日：2012-02-29
申请号：EP09750701
申请日：2009-01-06
发明人： CHUNG BONG HYUN , JEONG JINYOUNG , SONG NAM WOONG
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/152 , C09K11/02 , C09K11/65
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8.发明公开GENOME-WIDE CONSTRUCTION OF SCHIZOSACCHAROMYCES POMBE HETEROZYGOUS DELETION MUTANTS CONTAINING GENE-SPECIFIC BARCODES BY THE METHODS OF 4-ROUND SERIAL OR BLOCK PCR, OR TOTAL GENE SYNTHESIS THEREOF 审中-公开全基因组构建的基因特异性条形码CONTAINING粟酒裂殖酵母杂合缺失突变体以4轮的串联或嵌段PCR OR GESAMTGENSYNTHESE THEREOF过程
公开(公告)号：EP2268808A4
公开(公告)日：2011-09-14
申请号：EP08793534
申请日：2008-08-27
发明人： HOE KWANG LAE , KIM DONG UK , WON MI SUN , YOO HYANG SOOK , KIM DONG SUP , PARK HAN OH , CHUNG KYUNG SOOK , JANG YOUNG JOO , NAM MI YOUNG , HAN SANG JO , CHOI SHIN JUNG , BAEK SEUNG TAE , KIM HYONG BAI , HEO KYUNG SUN , LEE HYE MI , LEE MIN HO , PARK JO YOUNG
IPC分类号： C12N15/00
CPC分类号： C12N15/1034 , C12N1/00 , C40B30/00 , C40B40/02 , C40B50/00
摘要： A method comprising transforming Schizosaccharomyces pombe with a deletion cassette, constructed by four-round serial PCR, block PCR or total gene synthesis, containing a homologous recombination site is provided for preparing gene-targeted heterozygous deletion Schizosaccharomyces pombe. Also provided are gene-targeted hetero2ygous deletion Schizosaccharomyces pombe mutants prepared by the method, and a library of gene-targeted heterozygous deletion Schizosaccharomyces pombe mutants. Further, the library is useful in constructing a method and a kit for screening a drug's modes of action.
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9.发明公开A COMPOSITION COMPRISING AN EXTRACT OF TIARELL POLYPHYLLA AND TIARELLIC ACID ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY 有权成分含黄水枝属重楼和炎性隔离THEREOFTIARELLASÄURE，抗过敏性和抗哮喘活动EXTRACT
公开(公告)号：EP1924159A4
公开(公告)日：2010-10-20
申请号：EP06783327
申请日：2006-07-18
发明人： LEE HYEONG KYU , OH SEI RYANG , AHN KYUNG SEOP , LEE JOONG KU , LEE SAN KU , KIM JUNG HEE , KIM DOO YOUNG , QUAN GUI HUA , KWON OK KYOUNG , KIM EUN AH , CHOI SOON JA , SHEN GUANG HAI , KIM MI JIN , PARK BO YOUNG , MIN BYUNG SUN , HAN GYOON HEE , PARK HEA YOUNG , KIM GUN CHEOL , KIM JOO HEON , KIM SO YOUNG
IPC分类号： A61K36/185 , A23L33/00 , A61P37/08
CPC分类号： A61K36/185 , A23L33/105 , A23V2002/00 , A23V2200/304
摘要： The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC 4 release in vitro test and the suppressive effect on the IgE level and the cytokine(IL-4, IL-5 and IL- 13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
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公开(公告)号：EP2037939A4
公开(公告)日：2010-09-29
申请号：EP06812536
申请日：2006-11-10
发明人： PARK YOUNG WOO , KIM SEMI , JO KIWON , PARK JI HYUN , JUNG HEEKYUNG , LEE KWANG PYO , PARK SO JEONG , JANG YOUNG-SOON , CHOI SO-YOUNG , JUNG JOON-GOO , HONG HYO JEONG , YOON JEONG HO , PARK JONG-HO
IPC分类号： A61K31/7084 , A61P35/00
CPC分类号： A61K31/7084 , C12N15/1137 , C12N2310/14
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