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24 条记录 (耗时 0.011 秒)

    Thrombin-binding substance and process for preparing the same
    2.
    发明公开
    Thrombin-binding substance and process for preparing the same 失效
    硫蛋白结合物质及其制备方法

    公开(公告)号：EP0356836A3

    公开(公告)日：1990-03-28

    申请号：EP89115272.0

    申请日：1989-08-18

    申请人： KOWA COMPANY, LTD.

    发明人： Aoki, Nobuo ,  Kimura, Shigeru ,  Shiratsuchi, Masami

    IPC分类号： A61K35/22 ,  C12P21/00

    CPC分类号： C07K14/7455 ,  A61K38/00 ,  Y10S530/834

    摘要： Novel thrombin-binding substances (A) and (B) are disclosed. The thrombin-binding substances have the following characteristics:
    (a) molecular weight:
    Thrombin-binding substance (A):
    90,000-92,000 under reduced conditions
    55,000-58,000 under unreduced conditions Thrombin-binding substance (B):
    98,000-105,000 under reduced conditions
    60,000-65,000 under unreduced conditions (b) isoelectric point:
    Thrombin-binding substance (A): pH 6.0-6.8 Thrombin-binding substance (B): pH 5.8-6.5 (c) affinity: strong affinity to thrombin (d) activity:
    (1) capable of promoting the thrombin catalyzed activation of protein C (2) prolongs clotting time; and (e) stability: stable to denaturing agents (sodium dodecylsulfate and urea). The thrombin-binding substances are useful as a medicine for curing thrombosis.

    Azoxy compounds
    5.
    发明公开
    Azoxy compounds 失效
    AZOXY化合物

    公开(公告)号：EP0443513A3

    公开(公告)日：1991-11-21

    申请号：EP91102338.0

    申请日：1991-02-19

    申请人： KOWA COMPANY, LTD.

    发明人： Nakayama, Masahito ,  Deushi, Takeo ,  Takahashi, Yoshio ,  Ishiwata, Hiroyuki ,  Okuno, Yukihiro ,  Itoh, Hisakatsu ,  Shiratsuchi, Masami

    IPC分类号： C07C291/08 ,  A01N51/00 ,  A61K31/655

    CPC分类号： C07C291/08 ,  A01N51/00 ,  C07C2601/16

    摘要： A compound expressed by the formula:

    in which R₁₁, R₂₁ and R₃₁ are identical with or different from each other and each denotes a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a haloalkyl group, an alkoxy group, an alkylthio group, an aryl or an aralkyl group which aromatic ring is optionally substituted appropriately by one to three substituents or a heterocyclic group optionally substituted appropriately by one to three substituents, or R₁₁ and R₂₁ may together form an alkylene group, Y denotes O or NOH, with a proviso that where R₂₁ (or R₁₁) and R₃₁ denote a hydrogen atom at the same time, R₁₁ (or R₂₁) cannot represent an n-butyl group. This compound is useful as an antifungal agent.

    摘要翻译： 由下式表示的化合物：其中R11，R21和R31彼此相同或不同，表示氢原子，卤素原子，烷基，烯基，卤代烷基，烷氧基 基团，烷硫基，芳基或芳烷基，芳环任选被1至3个取代基任意取代或任选被1至3个取代基任意取代的杂环基，或者R 11和R 21可以一起形成亚烷基，Y表示 O或NOH，条件是当R 21（或R 11）和R 31同时表示氢原子时，R 11（或R 21）不能表示正丁基。 该化合物可用作抗真菌剂。

    Quinoline or hydroquinoline compounds, their preparation and pharmaceutical compostions comprising them
    7.
    发明公开
    Quinoline or hydroquinoline compounds, their preparation and pharmaceutical compostions comprising them 失效
    喹啉或Hydrochinolinverbindungen，它们的制备和含有它们的药物组合物。

    公开(公告)号：EP0107938A1

    公开(公告)日：1984-05-09

    申请号：EP83306052.8

    申请日：1983-10-05

    申请人： KOWA COMPANY, LTD.

    发明人： Shiratsuchi, Masami ,  Onogi, Kazuhiro ,  Sato, Seiichi ,  Ishihama, Hiroshi

    IPC分类号： C07D215/20 ,  C07D215/22 ,  C07D215/26 ,  C07D215/48 ,  C07D215/50 ,  C07D215/54 ,  C07D215/56 ,  A61K31/47

    CPC分类号： C07D407/12 ,  C07D215/20 ,  C07D215/26 ,  C07D215/32 ,  C07D215/48 ,  C07D215/56

    摘要： A substituted quinoline or hydroquinoline compound of formula (I)
    wherein

    R represents a hydrogen atom or a CF 3 group,
    A represents a direct bond or the group -CONH-,
    R' represents a hydrogen atom or an alkoxy-carbonyl group,
    n represents an integer of 1 to 4, and
    m represents 0 or 1, provided that when m is 0, the bond between the 1-position nitrogen atom and the 2-position carbon atom and the bond between the 3-position carbon atom and the 4-position carbon atom are both double bonds, and when m is 1, the two bonds are both single bonds, or a pharmaceutically acceptable acid addition salt thereof; a process for producing the aforesaid compound; and a pharmaceutical composition comprising the same.

    摘要翻译： 甲substituiertem喹啉或式（I）的氢喹啉化合物 worinřdarstellt氢原子或CF 3基团，A darstellt直接键或基团-CONH-，R分钟darstellt氢原子或烷氧基 - 羰基， ñdarstellt上述1〜4的整数，且m darstellt 0或1，条件做当m为0时，1位氮原子和2位碳原子和3-位碳原子之间的键和之间的键 4-位碳原子是两个双键，并且当m是1时，两个键均为单键，或其药学上可接受的酸加成盐; 用于制备上述化合物的方法; 和一种药物组合物是相同的。