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    Benzopyrans, their production and pharmaceutical compositions containing them
    2.
    发明公开
    Benzopyrans, their production and pharmaceutical compositions containing them 失效
    Benzopyrane，ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen。

    公开(公告)号：EP0042299A1

    公开(公告)日：1981-12-23

    申请号：EP81302700.0

    申请日：1981-06-16

    申请人： KOWA COMPANY, LTD.

    发明人： Shiratsuchi, Masami ,  Shimizu, Noboru ,  Shigyo, Hiromichi ,  Kyotani, Yoshinori ,  Kunieda, Hisashi ,  Kawamura, Kiyoshi ,  Sato, Seiichi ,  Akashi, Toshihiro ,  Nagakura, Masahiko ,  Sawada, Naotoshi ,  Uchida, Yasumi

    IPC分类号： C07D311/64 ,  C07D311/66 ,  C07D311/22 ,  C07D311/58 ,  A61K31/35

    CPC分类号： C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  Y10S514/821

    摘要： Benzopyrans represented by the formula
    wherein A represents a direct bond or -CH 2 O-

    R 1 represents a C 3 -C 5 alkyl group, a hydroxy-(C 3 -C 5 alkyl) group, a lower alkyl-amino-lower alkyl group, a ni- trato-(C 3 -C 5 alkyl) group or a phenyl-(C 1 -C 5 ) alkyl group where the phenyl may be substituted by a lower alkoxy group, R 2 represents hydrogen, halogen, OH, N0 2 , a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R 3 represents hydrogen or N0 2 , B represents a direct bond, a C 1 -C 7 alkylene group, a -O-lower alkylene group or a -CONH-lower alkylene group, and
    n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

    摘要翻译： 苯并吡喃由下式表示：其中A表示直接键或-CH 2 O-，R 1表示C 3 -C 5烷基，羟基 - （C 3 -C 5烷基），低级烷基 - 氨基 - 低级烷基 ，硝基 - （C 3 -C 5烷基）基或苯基 - （C 1 -C 5）烷基，其中苯基可以被低级烷氧基取代，R 2表示氢，卤素，OH，NO 2，氨基甲酰基，低级 烷基，低级烷氧基，低级亚烷基氧基或乙酰基，R 3表示氢或NO 2，B表示直接键，C 1 -C 7亚烷基，-O-低级亚烷基或-CONH-低级亚烷基 组，... n表示1或2; 并且它们的酸加成盐可用于例如降低心跳率，心肌耗氧量和血压。

    Quinoline or hydroquinoline compounds, their preparation and pharmaceutical compostions comprising them
    5.
    发明公开
    Quinoline or hydroquinoline compounds, their preparation and pharmaceutical compostions comprising them 失效
    喹啉或Hydrochinolinverbindungen，它们的制备和含有它们的药物组合物。

    公开(公告)号：EP0107938A1

    公开(公告)日：1984-05-09

    申请号：EP83306052.8

    申请日：1983-10-05

    申请人： KOWA COMPANY, LTD.

    发明人： Shiratsuchi, Masami ,  Onogi, Kazuhiro ,  Sato, Seiichi ,  Ishihama, Hiroshi

    IPC分类号： C07D215/20 ,  C07D215/22 ,  C07D215/26 ,  C07D215/48 ,  C07D215/50 ,  C07D215/54 ,  C07D215/56 ,  A61K31/47

    CPC分类号： C07D407/12 ,  C07D215/20 ,  C07D215/26 ,  C07D215/32 ,  C07D215/48 ,  C07D215/56

    摘要： A substituted quinoline or hydroquinoline compound of formula (I)
    wherein

    R represents a hydrogen atom or a CF 3 group,
    A represents a direct bond or the group -CONH-,
    R' represents a hydrogen atom or an alkoxy-carbonyl group,
    n represents an integer of 1 to 4, and
    m represents 0 or 1, provided that when m is 0, the bond between the 1-position nitrogen atom and the 2-position carbon atom and the bond between the 3-position carbon atom and the 4-position carbon atom are both double bonds, and when m is 1, the two bonds are both single bonds, or a pharmaceutically acceptable acid addition salt thereof; a process for producing the aforesaid compound; and a pharmaceutical composition comprising the same.

    摘要翻译： 甲substituiertem喹啉或式（I）的氢喹啉化合物 worinřdarstellt氢原子或CF 3基团，A darstellt直接键或基团-CONH-，R分钟darstellt氢原子或烷氧基 - 羰基， ñdarstellt上述1〜4的整数，且m darstellt 0或1，条件做当m为0时，1位氮原子和2位碳原子和3-位碳原子之间的键和之间的键 4-位碳原子是两个双键，并且当m是1时，两个键均为单键，或其药学上可接受的酸加成盐; 用于制备上述化合物的方法; 和一种药物组合物是相同的。

    Sulfonamide compounds
    6.
    发明公开
    Sulfonamide compounds 失效
    磺酰胺-Verbindungen。

    公开(公告)号：EP0330065A1

    公开(公告)日：1989-08-30

    申请号：EP89102586.8

    申请日：1989-02-15

    申请人： KOWA COMPANY, LTD.

    发明人： Tanabe, Sohei ,  Sato, Seiichi ,  Kyotani, Yoshinori ,  Ohta, Tomio ,  Uchida, Yasumi

    IPC分类号： C07D295/12 ,  C07D213/74

    CPC分类号： C07D213/74 ,  C07D295/13

    摘要： A sulfonamide compound represented by the following formula
    wherein R¹, R² and R³ are identical or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R⁴ represents a hydrogen atom, a lower alkyl group, or a substituted or unsub­stituted aralkyl group; R⁵ represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; R⁶ and R⁷ are identical or different and each represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; and n is an integer of 1 to 8,
    and an acid addition salt thereof. The compounds of formula (I) provided by this invention have some useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardio­vascular disorders such as angina pectoris, cerebral circulation disorder and thrombosis.

    摘要翻译： 由下式表示的磺酰胺化合物其中R 1，R 2和R 3相同或不同，并且各自表示氢原子，卤素原子，低级烷基或低级烷氧基 组; R 4表示氢原子，低级烷基或取代或未取代的芳烷基; R 5表示取代或未取代的芳基或取代或未取代的芳烷基; R 6和R 7相同或不同，各自表示氢原子，低级烷基或低级烷氧基; n为1〜8的整数，及其酸加成盐。 本发明提供的式（I）化合物具有一些有用的生物学活性，例如血管平滑肌上的解痉活性和抗血小板聚集活性，可用作治疗心血管疾病如心绞痛，脑循环障碍和 血栓形成。

    Aminoalkyl-substituted benzene derivatives, process for production thereof, and pharmaceutical composition thereof
    7.
    发明公开
    Aminoalkyl-substituted benzene derivatives, process for production thereof, and pharmaceutical composition thereof 失效
    氨基烷基取代的苯衍生物，其制备方法及其药物组合物的处理。

    公开(公告)号：EP0133259A2

    公开(公告)日：1985-02-20

    申请号：EP84108608.5

    申请日：1984-07-20

    申请人： KOWA COMPANY, LTD.

    发明人： Uchida, Yasumi ,  Shigyo, Hiromichi ,  Sato, Seiichi ,  Shibuya, Kimiyuki ,  Ohta, Tomio ,  Ishihama, Hiroshi

    IPC分类号： C07C103/50 ,  C07C93/14 ,  C07D295/12 ,  C07C102/00 ,  C07C85/00 ,  C07C87/22 ,  A61K31/16 ,  A61K31/13

    CPC分类号： C07D213/81 ,  C07C45/673 ,  C07C203/04 ,  C07C205/32 ,  C07D295/088 ,  C07D295/15 ,  C07C49/84

    摘要： An animoalkyl-substituted benzene derivative represented by the formula
    wherein R, represents a member selected from the class consisting of a hydrogen atom, lower alkyl groups, lower alkoxy groups, lower aliphatic acyl groups, halogen atoms and a trifluoroethoxy group; R 2 represents a hydrogen atom or a lower alkyl group; R 3 represents -ONO 2 , -CF 3 or F; R 4 and R 5' independently from each other, represent a member selected from the class consisting of a hydrogen atom, lower alkyl groups, halogen-substituted benzoyl groups, phenyl-substituted lower aliphatic acyl groups and a pyridinecarbonyl group, or R. and R 5 may form, together with the nitrogen atom to which they are bonded, a 6-membered hetero ring which may contain another hetero atom selected from O and N; X, and X 2 , independently from each other, represents an alkylene group having 1 to 8 carbon atoms; and B represents-O-or-NHCO-in which the nitrogen atom of -NHCO- is bonded to a carbon atom of the benzene ring; and an acid addition salt thereof; a process for production thereof; and pharmaceutical composition thereof.

    摘要翻译： 在animoalkyl-substituiertem苯衍生物由式代表worin R1 darstellt从类选自氢原子中选出的构件，低级烷基，低级烷氧基，低级脂肪族酰基基团，卤原子和三氟乙氧基基团; R2 darstellt一个氢原子或一个低级烷基; R3 darstellt -ONO 2，-CF 3或F; R4和R5，从海誓山盟unabhängig，表示从类选自氢原子中选出的构件，低级烷基，卤素 - substituiertem苯甲酰基，苯基 - 低级substituiertem脂肪族酰基和吡啶羰基，或R4和R5可形成 连同该氮原子与它们所键合的6元杂环，该杂环可以含有选自O和N选择的另一杂原子; X1和X2，从海誓山盟unabhängig，具有1至8个碳原子的亚烷基团的darstellt; 和B darstellt -O-或-NHCO-在哪-NHCO-的氮原子键合至苯环的碳原子上; 并涉及其酸加成盐; 对于它们的制备方法; 和它们的药物组合物。