公开(公告)号：EP0814782B1

公开(公告)日：2002-11-27

申请号：EP96942588.3

申请日：1996-12-20

申请人： KOWA COMPANY LTD. ,  NISSAN CHEMICAL INDUSTRIES, LIMITED

发明人： MURAMATSU, Toyojiro ,  MASHITA, Katsumi ,  SHINODA, Yasuo ,  SASSA, Hironori ,  KAWASHIMA, Hiroyuki ,  TANIZAWA, Yoshio ,  TAKEUCHI, Hideatsu

IPC分类号： A61K9/20 ,  A61K31/47

CPC分类号： A61K9/2013 ,  A61K9/2009 ,  A61K31/47 ,  A61K47/02 ,  A61K47/183

摘要： Disclosed is a pharmaceutical composition comprising (E)-3,5-dihydroxy-7-[4'-4'-fluorophenyl-2'-cyclopropyl-quinolin-3'-yl]-6-heptenoic acid, or its salt or ester, of which the aqueous solution or dispersion has a pH of from 7 to 8. The composition has good time-dependent stability and has no change in its outward appearance even after having been stored long.

公开(公告)号：EP0814782A1

公开(公告)日：1998-01-07

申请号：EP96942588.0

申请日：1996-12-20

申请人： KOWA COMPANY LTD. ,  NISSAN CHEMICAL INDUSTRIES, LIMITED

发明人： MURAMATSU, Toyojiro ,  MASHITA, Katsumi ,  SHINODA, Yasuo ,  SASSA, Hironori ,  KAWASHIMA, Hiroyuki ,  TANIZAWA, Yoshio ,  TAKEUCHI, Hideatsu

IPC分类号： A61K9 ,  A61K31 ,  A61K47 ,  A61P3

CPC分类号： A61K9/2013 ,  A61K9/2009 ,  A61K31/47 ,  A61K47/02 ,  A61K47/183

摘要： Disclosed is a pharmaceutical composition comprising (E)-3,5-dihydroxy-7-[4'-4'-fluorophenyl-2'-cyclopropyl-quinolin-3'-yl]-6-heptenoic acid, or its salt or ester, of which the aqueous solution or dispersion has a pH of from 7 to 8. The composition has good time-dependent stability and has no change in its outward appearance even after having been stored long.