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    PREGNANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
    4.
    发明授权
    PREGNANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
    PREGNANE衍生物及其制备方法

    公开(公告)号：EP0321572B1

    公开(公告)日：1993-06-09

    申请号：EP88902929.4

    申请日：1988-03-29

    申请人： KURARAY Co. LTD.

    发明人： TSUJI, Jiro ,  TAKAHASHI, Takashi ,  TSUJI, Masao ,  NAKAGAWA, Naoshi ,  TAKIGAWA, Tetsuo

    IPC分类号： C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J51/00 ,  C07J71/00 ,  C12P33/00

    CPC分类号： C07J71/001 ,  C07J9/00 ,  C07J17/00 ,  C07J41/0055 ,  C07J51/00

    摘要： Pregnane derivatives represented by general formula (I) (wherein A1 represents a hydrogen atom or a hydroxy group, A2 represents a substituent such as a hydroxy group when A1 represents a hydrogen atom, or A2 represents a hydrogen atom when A1 represents a hydroxy group, or A1 and A2 are combined together to form an oxo group; D1 represents a substituent such as a hydroxy group, and D2 represents a hydrogen atom, or D1 and D2 are combined together to form an epoxy group or a single bond; D3, D5 and D7 each represents a hydrogen atom, D4 represents a hydroxy group, and D6 represents a substituent such as a hydroxy group, or D3 and D4 may be combined together to form an epoxy group or a single bond, or D4 and D5 may be combined together to form a single bond, D5 and D6 may be combined together to form an epoxy group or a single bond, or D6 and D7 may be combined together to form a single bond; and X1 and X2 each represents a lower alkoxy group or, when combined together, they represent a lower alkylenedioxy or oxo group) and a process for their preparation. The pregnane derivatives are useful as intermediates for synthesizing vitamin D3 having a hydroxy group in the 1alpha-position.

    STEROID COMPOUNDS
    5.
    发明公开
    STEROID COMPOUNDS 失效
    类固醇VERBINDUNGEN。

    公开(公告)号：EP0377743A1

    公开(公告)日：1990-07-18

    申请号：EP88908376.2

    申请日：1988-09-28

    申请人： KURARAY CO., LTD.

    发明人： TSUJI, Jiro ,  TAKAHASHI, Takashi ,  TSUJI, Masao ,  NAKAGAWA, Naoshi ,  TAKIGAWA, Tetsuo

    IPC分类号： C07J9/00 ,  C07C401/00

    CPC分类号： C07J9/00 ,  C07C401/00 ,  C07J9/005 ,  C07J31/006 ,  C07J51/00 ,  C07J53/004 ,  C07J71/001 ,  C07J71/0042 ,  Y02P20/55

    摘要： Steroid compounds represented by general formulae (I), (II) or (III), wherein R 1 and R 2 each represents a hydrogen atom or a hydroxyprotecting group, R represents -CH 2 -X, a carboxyl group or a protected carboxyl group, X represents a substituent such as a hydroxy group, A 1 represents an aryl group, a lower alkyl group or an aralkyl group, and Z 1 , Z 2 , Z 3 and Z 4 each represents a hydrogen atom, a hydroxy group or a protected hydroxy group. The steroid compounds are useful as intermediates for synthesis of vitamin D 3 derivatives having a hydroxy group in the la position.

    摘要翻译： 类固醇衍生物 式（I），（II）和（III）是新的，其中R 1和R 2是H或羟基保护基gp; R为-CH2X，羧基或被保护的羧基; X是OH，酰基，低级烷氧基羰基或三烷基。 甲基氧基，（取代）烷氧基甲氧基，（取代）苄氧基，卤素，（取代）磺酰氧基，（取代）亚磺酰基或（取代）磺酰基; A1是芳基，低级烷基或芳烷基; Z 1，Z 2，Z 3和Z 4为H，OH或被保护的OH。

    PREGNANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
    6.
    发明公开
    PREGNANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效
    PREGNANABKÖMMLINGEUND VERFAHREN ZUR HERSTELLUNG。

    公开(公告)号：EP0321572A1

    公开(公告)日：1989-06-28

    申请号：EP88902929.4

    申请日：1988-03-29

    申请人： KURARAY CO., LTD.

    发明人： TSUJI, Jiro ,  TAKAHASHI, Takashi ,  TSUJI, Masao ,  NAKAGAWA, Naoshi ,  TAKIGAWA, Tetsuo

    IPC分类号： C07J9/00 ,  C07J17/00 ,  C07J41/00 ,  C07J51/00 ,  C07J71/00 ,  C12P33/00

    CPC分类号： C07J71/001 ,  C07J9/00 ,  C07J17/00 ,  C07J41/0055 ,  C07J51/00

    摘要： Pregnane derivatives represented by general formula (I) (wherein A 1 represents a hydrogen atom or a hydroxy group, A 2 represents a substituent such as a hydroxy group when A 1 represents a hydrogen atom, or A 2 represents a hydrogen atom when A 1 represents a hydroxy group, or A 1 and A 2 are combined together to form an oxo group; 0 1 represents a substituent such as a hydroxy group, and D 2 represents a hydrogen atom, or D 1 and D 2 are combined together to form an epoxy group or a single bond; D 3 , D 5 and D 7 each represents a hydrogen atom, D 4 represents a hydroxy group, and D 6 represents a substituent such as a hydroxy group, or D 3 and D 4 may be combined together to form an epoxy group or a single bond, or D 4 and D 5 may be combined together to form a single bond, D 5 and D 6 may be combined together to form an epoxy group or a single bond, or D 6 and D 7 may be combined together to form a single bond; and X 1 and X 2 each represents a lower alkoxy group or, when combined together, they represent a lower alkylenedioxy or oxo group) and a process for their preparation. The pregnane derivatives are useful as intermediates for synthesizing vitamin D 3 having a hydroxy group in the 1α-position.

    摘要翻译： 孕烯-2-甲醛衍生物（I）是新的：其中A1是H，A2是OH，酰氧基，低级烷氧基羰基氧基，N-低级烷基氨基甲酰氧基，N-芳基氨基甲酰氧基，N，N-二（低级烷基）氨基甲酰氧基，三取代。 甲硅烷氧基或烷氧基甲氧基; 或A1为OH，A2为H; 或A1和A2一起= 0; D1是OH，酰氧基，低级烷基羰基氧基，N-低级烷基氨基甲酰氧基，N-芳基氨基甲酰氧基，N，N-二（低级烷基）氨基甲酰氧基，三取代基。 甲硅烷氧基或烷氧基甲氧基，且D2为H; 或D1 / D2一起可以形成双键或环氧基; D3为H，D4为OH; 或D3 / D4一起是双键或环氧基; D5为H，D6为OH，低级烷氧基羰基氧基，酰氧基，N-低级烷基氨基甲酰氧基，N-丙烯酰氨基甲酰氧基，N，N-二（低级烷基） - 氨基甲酰氧基; 或D5 / D6一起是双键或环氧树脂; D4 / D5可以是双键; D7是H或D6 / D7一起可以是双键; X1和X2各自为低级烷氧基或一起形成= 0或亚烷基二氧基。 以下是优选的：（a）A1 / A2 = 0，D1 / D2和D3 / D4是双键，D5 = H，D6 = OH，D7 = H; （b）A1 / A2 = 0，D1 / D2为双键或环氧基，D3 / D4和D5 / D6为双键，D7 = H; （c）A1 = H，A2 = OH或低级烷酰氧基，或A1 / A2 = 0，D1 / D2为环氧基，D3 / D4为双键，D5 / D6为环氧基，D7 = （d）A1 = OH，A2 = H，D1 / D2为环氧基，D3 / D4和D5 / D6为双键，D7 = H; （e）D1 / D2和D3 / D4为环氧基，D5 / D6为双键，D7 = H; （f）D2 = H，D3 = H，D4 = OH，D5 / D6是双键，D7 = H，A1 = H; （g）D2 = D3 = H，D4 / D5为双键，D7 = H，A1 = H; （h）D1 / D2为环氧基，A1为H，A2为H或低级烷酰氧基，D3 = H，D4 / D5为双键，D7 = H或D6 / D7为双键; （i）D2 = H，A1 = H，D3 = H，D4 / D5和D6 / D7是双键。