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公开(公告)号：EP0038203B1
公开(公告)日：1985-07-24
申请号：EP81301613.6
申请日：1981-04-13
发明人： Kawai, Syuji , Yamane, Tadayuki , Abe, Michio , Ono, Toshihiko , Yamauchi, Shuji
IPC分类号： A61M1/34
CPC分类号： A61M1/3472 , A61M1/3482 , A61M1/3639
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公开(公告)号：EP0038203A3
公开(公告)日：1982-02-03
申请号：EP81301613
申请日：1981-04-13
发明人： Kawai, Syuji , Yamane, Tadayuki , Abe, Michio , Ono, Toshihiko , Yamauchi, Shuji
IPC分类号： A61M01/03
CPC分类号： A61M1/3472 , A61M1/3482 , A61M1/3639
摘要： A blood treatment apparatus realizing double-step-membrane filtration, namely separation of blood into plasma and a corpuscular fraction in a first membrane module 4 and separation of highmolecular-weight substances (e.g. y-globulin) in the plasma from low-molecular-weight substances (e.g. albumin) in a second membrane module 10 comprises a blood inlet circuit including a pump M 1 (1) connected to the first module 4 a plasma outlet circuit 9. which includes a pump M 2 (7) and that conveys plasma from module 4 to module 10, which has a plasma fraction outlet circuit 14 (including a pump M 3 (12)) for the high-molecular weight fraction removed in module 10, and a blood return circuit 15. which links up with a corpuscles outlet circuit 18 from module 4 to return purified blood to the patient. the flow rate ratio between pumps M 2 (7) and M 3 (12) being controllable so as to give a desired ratio of input to output of module 10, the plasma pressure being also controllable so that it is never substantially negative. The apparatus is effective, e.g. in the treatment of blood of patients with peripheral circulatory insufficiency due to arteriosclerosis and of patients with rheumatoid arthritis, which is an autoimmune disease
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公开(公告)号：EP0038203A2
公开(公告)日：1981-10-21
申请号：EP81301613.6
申请日：1981-04-13
发明人： Kawai, Syuji , Yamane, Tadayuki , Abe, Michio , Ono, Toshihiko , Yamauchi, Shuji
IPC分类号： A61M1/34
CPC分类号： A61M1/3472 , A61M1/3482 , A61M1/3639
摘要： A blood treatment apparatus realizing double-step-membrane filtration, namely separation of blood into plasma and a corpuscular fraction in a first membrane module 4 and separation of highmolecular-weight substances (e.g. y-globulin) in the plasma from low-molecular-weight substances (e.g. albumin) in a second membrane module 10 comprises a blood inlet circuit including a pump M 1 (1) connected to the first module 4 a plasma outlet circuit 9. which includes a pump M 2 (7) and that conveys plasma from module 4 to module 10, which has a plasma fraction outlet circuit 14 (including a pump M 3 (12)) for the high-molecular weight fraction removed in module 10, and a blood return circuit 15. which links up with a corpuscles outlet circuit 18 from module 4 to return purified blood to the patient. the flow rate ratio between pumps M 2 (7) and M 3 (12) being controllable so as to give a desired ratio of input to output of module 10, the plasma pressure being also controllable so that it is never substantially negative.
The apparatus is effective, e.g. in the treatment of blood of patients with peripheral circulatory insufficiency due to arteriosclerosis and of patients with rheumatoid arthritis, which is an autoimmune disease摘要翻译： 实现双步膜过滤的血液处理装置，即将血液分离成等离子体并在第一膜组件4中分离红细胞，将血浆中的高分子量物质（如γ-球蛋白）从低分子量 第二膜组件10中的物质（例如白蛋白）包括血液入口回路，其包括连接到第一模块4的泵M1（1），等离子体出口回路9，其包括泵M2（7），并且将来自模块 4至模块10，其具有用于在模块10中除去的高分子量级分的血浆分数出口回路14（包括泵M3（12））和与血管出口回路18连接的血液回流回路15 从模块4将净化的血液返回到患者，泵M2（7）和M3（12）之间的流量比可控，以便给出模块10的输入与输出的期望比例，等离子体压力也是可控的 那是nev 基本上是负的。 该装置是有效的，例如， 在治疗由于动脉硬化引起的外周循环功能不全的患者和作为自身免疫疾病的类风湿性关节炎患者的血液中。
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