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    Peptides for use in determining serum thymic factor
    2.
    发明公开
    Peptides for use in determining serum thymic factor 失效
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    公开(公告)号：EP0043247A1

    公开(公告)日：1982-01-06

    申请号：EP81302874.3

    申请日：1981-06-25

    申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

    发明人： Yanaihara, Noboru ,  Konno, Koji

    IPC分类号： C07C103/52 ,  G01N33/56

    CPC分类号： C07K7/062 ,  G01N33/534 ,  G01N33/6863 ,  Y10S930/18

    摘要： Serum thymic factor (STF) occurs in minute amounts in blood, making its determination difficult. It has been found that peptides having a primary structure represented by the formula: wherein

    (1) X is H-Tyr-Gln-Ala-Lys and Y is a hydroxyl group,
    (2) X is pGlu-Ala-Lys(N e- Tyr-H) and Y is a hydroxyl group, or

    (3) X is pGlu-Ala-Lys and Y is TyrOH, can be radioactively labelled and used to determine STF. These peptides can be synthesized by bonding a predetermined amino acid or peptide to the N-end of H-Asn-OH, H-Asn-Tyr-OH or a peptide of the appropriate primary structure and terminating in -Asn-OH or -ASn-Tyr-OH at its C-end without protecting the carboxyl group at the C-end of said H-Asn-OH, H-Asn-Tyr-OH or peptide terminating in -Asn-OH or -Asn-Tyr-OH at its C-end, and as desired elongating the resulting peptide chain from the N-end by the bonding of further predetermined amino acid(s) and/or peptide(s), to obtain the desired peptide.

    摘要翻译： 血清胸腺因子（STF）在血液中发生微量，难以确定。 已经发现，具有由下式表示的一级结构的肽：X-Ser-Gln-Gly-Gly-Ser-Asn-Y（I）...其中...（1）X是H-Tyr-Gln-Ala- Lys和Y是羟基，...（2）X是pGlu-Ala-Lys（Nε-Tyr-H），Y是羟基，或...（3）X是pGlu-Ala-Lys和Y 是TyrOH，可以放射性标记并用于确定STF。 这些肽可以通过将预定的氨基酸或肽键合到H-Asn-OH，H-Asn-Tyr-OH的N末端或适当的一级结构的肽并且终止于-Asn-OH或-ASn -Tyr-OH，而不保护所述H-Asn-OH，H-Asn-Tyr-OH的C末端的羧基或终止于-Asn-OH或-Asn-Tyr-OH的肽 其C-末端，并且根据需要通过进一步预定的氨基酸和/或肽的键合从N末端延伸得到的肽链，以获得所需的肽。