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    PYRAZOLOPYRIDYLPYRIDAZINONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
    1.
    发明公开
    PYRAZOLOPYRIDYLPYRIDAZINONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 失效
    EY VERFAHREN ZU IHRER HERSTELLUNG的吡唑并吡啶并吡啶

    公开(公告)号：EP0989129A1

    公开(公告)日：2000-03-29

    申请号：EP97941255.8

    申请日：1997-09-26

    申请人： KYORIN PHARMACEUTICAL CO., LTD.

    发明人： KOUNO, Yasushi ,  OGATA, Takenobu ,  AWANO, Katsuya ,  MATSUZAWA, Kayoko ,  TOORU, Taroh

    IPC分类号： C07D471/04 ,  A61K31/50

    CPC分类号： C07D471/04

    摘要： Novel pyrazolopyridylpyridazinone derivatives characterized by being represented by general formula (1)
    and pharmacologically acceptable salts thereof, which exhibit a phosphodiesterase inhibiting activity and have a selective potent bronchodilating effect on the respiratory tract: a process for the preparation of them: and bronchodilators containing the same as the activity ingredient: wherein R 1 is C 1 -C 4 lower alkyl or C 3 -C 6 cycloalkyl: and R 2 , R 3 , R 4 and R 5 are each independently hydrogen, C 1 -C 4 lower alkyl or phenyl, or alternatively R 3 and R 5 may be united to form a double bond.

    摘要翻译： 新型吡唑并吡啶酮衍生物，其特征在于由通式（1）表示的化合物及其药理学上可接受的盐，其具有磷酸二酯酶抑制活性并对呼吸道具有选择性有效的支气管扩张作用：其制备方法：和支气管扩张剂 含有与活性成分相同的化合物：其中R 1为C 1 -C 4低级烷基或C 3 -C 6环烷基; R 2，R 3，R 4和R 5各自独立地为氢， C 1 -C 4低级烷基或苯基，或者R 3和R 5可以结合形成双键。

    N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
    3.
    发明公开
    N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 失效
    VERFAHREN ZU IHRER HERSTELLUNG的N-BENZYLDIOXOTHIAZOLIDYLBENZAMID-DERIVATE

    公开(公告)号：EP0846693A1

    公开(公告)日：1998-06-10

    申请号：EP96920002.1

    申请日：1996-05-30

    申请人： KYORIN PHARMACEUTICAL CO., LTD.

    发明人： MAEDA, Toshio ,  NOMURA, Masahiro ,  AWANO, Katsuya ,  KINOSHITA, Susumu ,  SATOH, Hiroya ,  MURAKAMI, Koji, Prescene Nogi Highlands 704 ,  TSUNODA, Masaki

    IPC分类号： C07D277/34 ,  C07D417/12 ,  A61K31/425

    CPC分类号： C07D417/12 ,  C07D277/34

    摘要： The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1)
    [wherein R 1 and R 2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R 1 and R 2 link to form a methylenedioxy group, R 3 denotes a lower alkoxy group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, and dotted line indicates double bond or single bond in combination with solid line], and processes for preparing the same.

    摘要翻译： 本发明提供新的N-苄基二硫代噻唑烷基苯甲酰胺衍生物，其改善胰岛素抵抗并具有有效的降血糖和降脂作用及其制备方法，涉及以通式（1）表示的N-苄基二硫代噻唑烷基苯甲酰胺衍生物 其中R 1和R 2分别表示相同或不同的氢原子，碳原子数为1〜4的低级烷基，碳原子数为1〜3的低级烷氧基，碳原子数为1〜3的低级卤代烷基 ，碳原子数为1〜3的低级卤代烷氧基，卤素原子，羟基，硝基，可被碳原子数1〜3的低级烷基或杂环取代的氨基，或R 1， 和R 2连接形成亚甲二氧基，R 3表示碳原子数1〜3的低级烷氧基，羟基或卤素原子，虚线表示双键或单键与固体组合 lineÜ及其制备方法。

    O-ANISAMIDE DERIVATIVES
    6.
    发明公开
    O-ANISAMIDE DERIVATIVES 有权
    O型ANISAMID衍

    公开(公告)号：EP1219595A1

    公开(公告)日：2002-07-03

    申请号：EP00956871.8

    申请日：2000-09-01

    申请人： KYORIN PHARMACEUTICAL CO., LTD.

    发明人： SATOH, Hiroya ,  KOMURO, Masakatsu ,  MURAKAMI, Koji ,  AWANO, Katsuya

    IPC分类号： C07C235/60 ,  C07C317/46 ,  C07C323/60 ,  A61K31/166 ,  A61K31/192 ,  A61K31/235 ,  A61P3/06 ,  A61P3/10 ,  A61P43/00

    CPC分类号： C07C317/46 ,  C07C235/60 ,  C07C323/60

    摘要： The invention provides o-anisamide derivatives and their addition salts effective for the prevention and/or therapy of metabolic diseases such as hyperlipidemia and diabetes, in which peroxisome proliferator-activated receptor (PPAR) being intranuclear receptor, in particular, human PPAR participates, as agonistic drugs thereon, and processes for preparing them.
    The invention relates to o-anisamide derivatives represented by a general formula (1)
    [wherein R denotes a carboxyl group, carboxymethyl group or CH 2 CHXCOY (here X denotes a mercapto group or S(O)nMe (n=0, 1 or 2) and Y denotes an amino group or hydroxyl group)], their medicinally acceptable salts, their hydrates, and processes for preparing them.

    摘要翻译： 本发明提供了用于预防和/或治疗代谢性疾病如高脂血症和糖尿病的邻甲氧基苯甲酰胺衍生物及其加成盐，其中作为核内受体的过氧化物酶体增殖物激活受体（PPAR），特别是人类PPAR参与， 激素药物及其制备方法。 本发明涉及由通式（1）表示的邻甲氧基苯甲酰胺衍生物，其中R表示羧基，羧甲基或CH 2 CHXCOY（这里X表示巯基或S（O）nMe（n = 0,1或 2），Y表示氨基或羟基），其药学上可接受的盐，它们的水合物及其制备方法。

    N-SUBSTITUTED DIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
    8.
    发明公开
    N-SUBSTITUTED DIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 失效
    N-SUBSTITUIERTE DIOXOTHIAZOLIDYL-BENZAMID-DERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

    公开(公告)号：EP0881219A1

    公开(公告)日：1998-12-02

    申请号：EP96942555.2

    申请日：1996-12-16

    申请人： KYORIN PHARMACEUTICAL CO., LTD.

    发明人： MAEDA, Toshio ,  NOMURA, Masahiro ,  AWANO, Katsuya ,  KINOSHITA, Susumu 3-10-10, Shinshiraoka ,  SATOH, Hiroya ,  MURAKAMI, Koji Prescene Nogi Highlands 704 ,  TSUNODA, Masaki

    IPC分类号： C07D277/34 ,  C07D417/12 ,  A61K31/425 ,  A61K31/44

    CPC分类号： C07D417/12 ,  C07D277/34

    摘要： The invention provides novel N-substituted dioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic effect and lipid-lowering effect, and the process for preparing them, and relates to N-substituted dioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1)
    [wherein R 1 and R 2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms or hydroxyl groups, or R 1 and R 2 combine to form a methylenedioxy group, R 3 denotes a hydrogen atom, lower alkoxys group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, R 4 denotes a hydrogen or lower alkyl group with carbon atoms of 1 to 3, n denotes an integer of 0 to 2, and X denotes N or CH], and process for preparing the same.

    摘要翻译： 本发明提供新的N-取代二氧代噻唑烷基苯甲酰胺衍生物，其改善胰岛素抵抗并具有有效的降血糖作用和降脂作用及其制备方法，涉及N-取代的二氧代噻唑烷基苯甲酰胺衍生物，其特征在于通式（1 ）其中R 1和R 2分别相同或不同，表示氢原子，碳原子数1〜4的低级烷基，碳原子数1〜3的低级烷氧基，碳原子的低级卤代烷基 1至3，具有1至3个碳原子的低级卤代烷氧基，卤素原子或羟基或R 1和R 2结合形成亚甲二氧基，R 3表示氢原子，低级烷氧基 碳原子数1〜3，羟基或卤素原子，R 4表示碳原子数为1〜3的氢原子或低级烷基，n表示0〜2的整数，X表示N或CH原子， 制备方法