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    PYRAZOLOPYRIDYLPYRIDAZINONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
    1.
    发明公开
    PYRAZOLOPYRIDYLPYRIDAZINONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 失效
    EY VERFAHREN ZU IHRER HERSTELLUNG的吡唑并吡啶并吡啶

    公开(公告)号：EP0989129A1

    公开(公告)日：2000-03-29

    申请号：EP97941255.8

    申请日：1997-09-26

    申请人： KYORIN PHARMACEUTICAL CO., LTD.

    发明人： KOUNO, Yasushi ,  OGATA, Takenobu ,  AWANO, Katsuya ,  MATSUZAWA, Kayoko ,  TOORU, Taroh

    IPC分类号： C07D471/04 ,  A61K31/50

    CPC分类号： C07D471/04

    摘要： Novel pyrazolopyridylpyridazinone derivatives characterized by being represented by general formula (1)
    and pharmacologically acceptable salts thereof, which exhibit a phosphodiesterase inhibiting activity and have a selective potent bronchodilating effect on the respiratory tract: a process for the preparation of them: and bronchodilators containing the same as the activity ingredient: wherein R 1 is C 1 -C 4 lower alkyl or C 3 -C 6 cycloalkyl: and R 2 , R 3 , R 4 and R 5 are each independently hydrogen, C 1 -C 4 lower alkyl or phenyl, or alternatively R 3 and R 5 may be united to form a double bond.

    摘要翻译： 新型吡唑并吡啶酮衍生物，其特征在于由通式（1）表示的化合物及其药理学上可接受的盐，其具有磷酸二酯酶抑制活性并对呼吸道具有选择性有效的支气管扩张作用：其制备方法：和支气管扩张剂 含有与活性成分相同的化合物：其中R 1为C 1 -C 4低级烷基或C 3 -C 6环烷基; R 2，R 3，R 4和R 5各自独立地为氢， C 1 -C 4低级烷基或苯基，或者R 3和R 5可以结合形成双键。