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1.发明公开
公开(公告)号：EP0254149A2
公开(公告)日：1988-01-27
申请号：EP87109949.5
申请日：1987-07-09
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Fujimori, Shizuyoshi , Kinoshita, Susumu , Matsukubo, Hiroshi
IPC分类号： C07D498/20 , C07D471/20 , C07D513/20 , C07D498/06 , C07D471/06 , C07D513/06
CPC分类号： C07D471/06 , C07D471/20 , C07D498/06 , C07D498/20 , C07D513/06 , C07D513/20
摘要： This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of the formula;
which have potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications.
The invented processes are useful as improved and convenient method for a large scale manufacture.摘要翻译： 本发明涉及制备下式的螺 - 连接的吡咯烷-2,5-二酮的新方法; 其对醛糖还原酶具有有效的抑制活性，并且可用于减少和预防慢性糖尿病并发症。 本发明的方法作为用于大规模生产的改进和方便的方法是有用的。
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2.发明公开The process for the manufacture of spiro-linked pyrrolidine-2,5-dione derivatives 失效维生素Zur Herstellung von spirogebundenen吡咯烷-2,5-dionderivaten。
公开(公告)号：EP0253319A2
公开(公告)日：1988-01-20
申请号：EP87109950.3
申请日：1987-07-09
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Kasuga, Kazunori , Fujimori, Shizuyoshi , Kinoshita, Susumu , Matsukubo, Hiroshi
IPC分类号： C07D498/20 , C07D471/20 , C07D513/20
CPC分类号： C07D471/20 , C07D498/20 , C07D513/20
摘要： This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of formula;
which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications.
The invented processes are useful as improved and convenient method for a large scale manufacture.摘要翻译： 本发明涉及用于制备式的螺相联吡咯烷-2,5-二酮的新方法; 其对醛糖还原酶具有有效的抑制活性，可用于减少和预防慢性糖尿病并发症。 本发明的方法可用于大规模制造的改进和方便的方法。
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3.发明公开
公开(公告)号：EP0171739A1
公开(公告)日：1986-02-19
申请号：EP85109896.2
申请日：1985-08-06
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D401/12 , C07D333/38 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/04
摘要： This invention relates to novel imidazo (1, 5-a) pyrimidines, with antifungal activities having the formula
wherein R, is halogen, R 2 is hydrogen or halogen, X is a sulfur, a sulfinyl group, a sulfonyl group or an oxygen atom, m and n are each independently 0 or 1, A is a phenyl group which may be substituted, a cycloalkyl group or an aromatic heterocyclic group which may be substituted.-
4.发明授权
公开(公告)号：EP0171739B1
公开(公告)日：1990-01-10
申请号：EP85109896.2
申请日：1985-08-06
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D401/12 , C07D333/38 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/04
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5.发明公开The process for the manufacture of spiro-linked pyrrolidine-2,5-dione derivatives 失效螺旋连接的吡咯烷-2,5-二酮衍生物的制备方法
公开(公告)号：EP0253319A3
公开(公告)日：1989-08-30
申请号：EP87109950.3
申请日：1987-07-09
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Kasuga, Kazunori , Fujimori, Shizuyoshi , Kinoshita, Susumu , Matsukubo, Hiroshi
IPC分类号： C07D498/20 , C07D471/20 , C07D513/20
CPC分类号： C07D471/20 , C07D498/20 , C07D513/20
摘要： This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of formula;
which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications. The invented processes are useful as improved and convenient method for a large scale manufacture.-
6.发明授权
公开(公告)号：EP0134928B1
公开(公告)日：1988-02-03
申请号：EP84107134.3
申请日：1984-06-20
发明人： Irikura, Tsutomu , Suzue, Seigo , Uchida, Hiroaki , Shinoda, Hirotaka , Murayama, Satoshi , Kinoshita, Susumu
IPC分类号： C07D487/04 , A61K31/505 , A61K31/415
CPC分类号： C07D239/54 , C07D487/04
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7.发明公开
公开(公告)号：EP0254149A3
公开(公告)日：1989-08-30
申请号：EP87109949.5
申请日：1987-07-09
发明人： Masuzawa, Kuniyoshi , Okamura, Kyuya , Fujimori, Shizuyoshi , Kinoshita, Susumu , Matsukubo, Hiroshi
IPC分类号： C07D498/20 , C07D471/20 , C07D513/20 , C07D498/06 , C07D471/06 , C07D513/06
CPC分类号： C07D471/06 , C07D471/20 , C07D498/06 , C07D498/20 , C07D513/06 , C07D513/20
摘要： This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of the formula;
which have potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications. The invented processes are useful as improved and convenient method for a large scale manufacture.-
公开(公告)号：EP0134928A1
公开(公告)日：1985-03-27
申请号：EP84107134.3
申请日：1984-06-20
发明人： Irikura, Tsutomu , Suzue, Seigo , Uchida, Hiroaki , Shinoda, Hirotaka , Murayama, Satoshi , Kinoshita, Susumu
IPC分类号： C07D487/04 , A61K31/505 , A61K31/415
CPC分类号： C07D239/54 , C07D487/04
摘要： his invention relates to a novel imidazo[1,5-a]-pyrimidine derivatives and process for their preparation. Moreover, it relates to a novel imidazo[1,5-a]pyrimidine derivatives and salts thereof having antifungal activities, and process for their preparation.
摘要翻译： 本发明涉及一种新的咪唑并[1,5-a] - 嘧啶衍生物及其制备方法。 此外，它涉及具有抗真菌活性的新的咪唑并[1,5-a]嘧啶衍生物及其盐及其制备方法。
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