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    METHOD FOR PRODUCING 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE
    4.
    发明公开
    METHOD FOR PRODUCING 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE 审中-公开
    用于生产3,4-二取代吡咯烷

    公开(公告)号：EP2634172A4

    公开(公告)日：2014-01-29

    申请号：EP11836226

    申请日：2011-10-24

    申请人： KYORIN SEIYAKU KK

    发明人： ARAYA ICHIRO ,  KIYOTA KOICHI ,  NAGAO MUNEKI

    IPC分类号： C07D207/24 ,  C07B53/00 ,  C07B61/00 ,  C07C269/06

    CPC分类号： C07D207/24 ,  C07B53/00 ,  C07C227/18 ,  C07C269/06 ,  C07C2601/02 ,  C07D207/16 ,  C07D207/277 ,  Y02P20/55 ,  C07C271/22

    摘要： The present invention provides an inexpensive and industrially advantageous method for producing an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxypyrrolidine derivative or it's enantiomer, which is a key intermediate for producing a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or it's enantiomer useful as an intermediate for producing pharmaceuticals. The present invention relates to a method for producing an optically active anti-(3S,4R)-4-hydroxypyrrolidine-3-carboxamide derivative, or it's enantiomer by carrying out asymmetric hydrogenation using an optically active catalyst of a 4-oxopyrrolidine-3-carboxamide derivative represented by the general formula (I). [in the formula (I), PG 1 represents a protective group for an amino group, and R 1 represents hydrogen, a C1 to C6 alkyl group which may be substituted, or a C3 to C8 cycloalkyl group which may be substituted].