公开(公告)号：EP0846693A4

公开(公告)日：1999-03-03

申请号：EP96920002

申请日：1996-05-30

申请人： KYORIN SEIYAKU KK

发明人： MAEDA TOSHIO ,  NOMURA MASAHIRO ,  AWANO KATSUYA ,  KINOSHITA SUSUMU ,  SATOH HIROYA ,  MURAKAMI KOJI ,  TSUNODA MASAKI

IPC分类号： C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  C07C67/347 ,  C07C69/76 ,  C07C69/84 ,  C07C69/92 ,  C07D277/34 ,  C07D417/12

CPC分类号： C07D417/12 ,  C07D277/34

摘要： Novel N-benzyldioxothiazolidylbenzamide derivatives represented by general formula (1) which improve insulin resistance and have potent hypoglycemic and lipid-lowering effects, wherein R?1 and R2¿ are the same or different and each represents hydrogen, lower (C¿1-4?) alkyl, lower (C1-3) alkoxy, lower (C1-3) haloalkyl, lower (C1-3) haloalkoxy, halogeno, hydroxy, nitro, amino optionally substituted by lower (C1-3) alkyl or a heterocycle, or R?1 and R2¿ may be bonded to each other to thereby form methylenedioxy; R3 represents lower (C¿1-3?) alkoxy, hydroxy or halogeno; and --- represents a double or single bond.

公开(公告)号：EP0881219A4

公开(公告)日：2000-01-26

申请号：EP96942555

申请日：1996-12-16

申请人： KYORIN SEIYAKU KK

发明人： MAEDA TOSHIO ,  NOMURA MASAHIRO ,  AWANO KATSUYA ,  KINOSHITA SUSUMU ,  SATOH HIROYA ,  MURAKAMI KOJI ,  TSUNODA MASAKI

IPC分类号： C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61P3/06 ,  A61P3/08 ,  A61P43/00 ,  C07D277/34 ,  C07D417/12

CPC分类号： C07D417/12 ,  C07D277/34

摘要： Novel N-substituted dioxothiazolidylbenzamide derivatives having an improved insulin resistance and potent hypoglycemic and hypolipidemic effects and represented by general formula (1), wherein R?1 and R2¿ may be the same or different and each represents hydrogen, C¿1-4? alkyl, C1-3 alkoxy, C1-3 haloalkyl, C1-3 haloalkoxy, halogeno, or hydroxy, or R?1 and R2¿ are bonded to each other to thereby form methylenedioxy; R3 represents hydrogen, C¿1-3? alkoxy, hydroxy, or halogeno; R?4¿ represents hydrogen or C¿1-3? alkyl; n represents an integer of 0 to 2; and X represents N or CH.