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    PYRROLOCARBAZOLE DERIVATIVES
    1.
    发明公开
    PYRROLOCARBAZOLE DERIVATIVES 失效
    吡咯卡拉巴唑衍生物

    公开(公告)号：EP0768311A1

    公开(公告)日：1997-04-16

    申请号：EP96905022.8

    申请日：1996-03-07

    申请人： Kyowa Hakko Kogyo Co., Ltd.

    发明人： IKUINA, Yoji ,  MURAKATA, Chikara ,  SAITOH, Yutaka ,  SHIOTSU, Yukimasa ,  IIDA, Takako ,  TAMAOKI, Tatsuya ,  YAMASHITA, Kinya ,  AKINAGA, Shiro

    IPC分类号： C07D487/04 ,  A61K31/41 ,  A61K31/44

    CPC分类号： C07D487/04

    摘要： A pyrrolocarbazole derivative and a pharmaceutically acceptable salt thereof having the following formula (I):
    wherein R 1 is lower alkyl or aralkyl; R 2 is hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, or substituted or unsubstituted aralkyl; R 3 , R 4 , R 5 , R 6 and R 7 may be the same or different, and are hydrogen, halogen, nitro, substituted or unsubstituted lower alkanoyl, NR 9 R 10 , or OR 11 ; R 8 is hydrogen or is combined with R 3 to form -CONR 12 -; and when R 1 is benzyl; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are not simultaneously hydrogen.
    A compound of the present invention stimulates platelet production and is useful for treatment of thrombocytopenia.

    摘要翻译： 具有下式（I）的吡咯并咔唑衍生物及其药学上可接受的盐：其中R1为低级烷基或芳烷基; R2是氢，取代或未取代的低级烷基，低级链烯基或取代或未取代的芳烷基; R3，R4，R5，R6和R7可以相同或不同，为氢，卤素，硝基，取代或未取代的低级烷酰基，NR9R10或OR11; R8是氢或与R3结合形成-CONR12-​​; 当R1是苄基时; R2，R3，R4，R5，R6，R7和R8不同时为氢。 本发明的化合物刺激血小板产生并可用于治疗血小板减少症。