利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.012 秒)

    EPOXYCYCLOHEXENEDIONE DERIVATIVE
    2.
    发明授权
    EPOXYCYCLOHEXENEDIONE DERIVATIVE 失效
    环氧环己烯衍生物

    公开(公告)号：EP0670317B1

    公开(公告)日：2000-03-08

    申请号：EP94927068.0

    申请日：1994-09-20

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： KANEKO, Masami ,  SAITOH, Yutaka ,  AKINAGA, Shiro ,  OKABE, Masami ,  AKASAKA, Kazuhito ,  NAKANO, Hirofumi

    IPC分类号： C07D303/36 ,  A61K31/335

    CPC分类号： C07D303/36

    摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C10-C25 linear or branched alkanoyl, C10-C25 linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.

    摘要翻译： 通式（I）表示的环氧基环己二酮衍生物或其药理学上允许的盐，式中，R表示碳原子数10〜25的直链状或支链状的烷酰基，碳原子数10〜25的直链烯酰基或式（A）所示的基团， 到4.这种化合物具有抗菌和抗肿瘤活性。

    PROCESS FOR PRODUCING DISACCHARIDES AND NOVEL SACCHARIDES
    4.
    发明公开
    PROCESS FOR PRODUCING DISACCHARIDES AND NOVEL SACCHARIDES 失效
    VERFAHREN ZUR HERSTELLUNG VON DISACCHARIDEN UND SACCHARIDEN

    公开(公告)号：EP0717047A1

    公开(公告)日：1996-06-19

    申请号：EP94932166.5

    申请日：1994-12-08

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： AISAKA, Kazuo ,  SAITOH, Yutaka ,  UOSAKI, Youichi

    IPC分类号： C07H3/08 ,  C12P19/12 ,  C12N9/96

    CPC分类号： C07H3/04 ,  C12P19/12

    摘要： A process for producing a disaccharide by conducting the condensation reaction of β-glucose-1-phosphate with a monosaccharide in an aqueous medium in the presence of an enzyme source originating in a microorganism of the genus Cattellatospora , Kineosporia , Propionibacterium or Enterococcus and having a sugar phosphorolytic activity, and harvesting the disaccharide formed in the medium. The obtained novel disaccharides are useful as medicine, food, cosmetic and enzyme stabilizer.

    摘要翻译： 一种通过在起源于卡特拉菌属（Cattellatospora），动球菌属（Kateosporia），丙酸杆菌属（Proinibacterium）或肠球菌属（Enterococcus）的微生物的酶源的存在下，在水性介质中进行β-葡萄糖-1-磷酸与单糖的缩合反应来生产二糖的方法， 糖溶解活性，并收获培养基中形成的二糖。 获得的新型二糖可用作药物，食品，化妆品和酶稳定剂。

    EPOXYCYCLOHEXENEDIONE DERIVATIVE
    6.
    发明公开
    EPOXYCYCLOHEXENEDIONE DERIVATIVE 失效
    环氧环己烯衍生物

    公开(公告)号：EP0670317A1

    公开(公告)日：1995-09-06

    申请号：EP94927068.0

    申请日：1994-09-20

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： KANEKO, Masami ,  SAITOH, Yutaka ,  AKINAGA, Shiro ,  OKABE, Masami ,  AKASAKA, Kazuhito ,  NAKANO, Hirofumi

    IPC分类号： C07D303/36 ,  A61K31/335

    CPC分类号： C07D303/36

    摘要： An epoxycyclohexenedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R represents C₁₀-C₂₅ linear or branched alkanoyl, C₁₀-C₂₅ linear alkenoyl or a group represented by formula (A), wherein n represents an integer of 1 to 4. This compound has antibacterial and antitumoral activities.

    摘要翻译： 由通式（Ⅰ）表示的环氧环己烯二酮衍生物或其药理学上可接受的盐，其中R代表C 10 -C 25直链或支链烷酰基，C 10 -C 25直链烯酰基或式（A）代表的基团，其中n代表整数1 到4.这种化合物具有抗菌和抗肿瘤活性。

    FARNESYLTRANSFERASE INHIBITOR
    7.
    发明公开
    FARNESYLTRANSFERASE INHIBITOR 失效
    法尼基转移酶抑制剂。

    公开(公告)号：EP0670314A1

    公开(公告)日：1995-09-06

    申请号：EP94927069.8

    申请日：1994-09-20

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： KANDA, Yutaka ,  SAITOH, Yutaka ,  AKASAKA, Kazuhito ,  MIZUKAMI, Tamio ,  NAKANO, Hirofumi

    IPC分类号： C07D241/08 ,  C07D513/08 ,  A61K31/495 ,  A61K31/54

    CPC分类号： C07D513/08 ,  A61K31/495 ,  A61K31/54 ,  C07D241/08

    摘要： A farnesyltransferase inhibitor and an antitumor drug each containing a piperazinedione derivative represented by general formula (I) as the active ingredient, wherein R¹ and R² are the same or different from each other and each represents lower alkyl, lower alkoxyalkyl, or (un)substituted aryl or aralkyl; R³ and R⁴ are the same or different from each other and each represents mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio or aryloxycarbonylthio, or R³ and R⁴ are combined with each other to represent a disulfide bond; and R⁵ and R⁶ are the same or different from each other and each represents hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl or aralkyl.

    LK6-A DERIVATIVES
    9.
    发明公开
    LK6-A DERIVATIVES 有权
    LK6-A-衍生物

    公开(公告)号：EP1097934A1

    公开(公告)日：2001-05-09

    申请号：EP99929753.4

    申请日：1999-07-08

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： AKAMA, Tsutomu ,  NAGATA, Hiroyuki ,  HASEGAWA, Atsuhiro ,  UE, Harumi ,  TAKAHASHI, Isami ,  SAITOH, Yutaka ,  MOCHIDA, Kenichi ,  IKEDA, Shun-ichi ,  KANDA, Yutaka

    IPC分类号： C07D471/06 ,  A61K31/47

    CPC分类号： C07D471/06

    摘要： LK6-A derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, which exhibit immunosuppressive, cytostatic and antitumor effects and so on, wherein R 1 is a lower alkanoyl or acryloyl group which may be substituted with, e.g., lower alkoxy, or the like; R 2 is hydrogen, halogeno or the like; R 2' is hydrogen, or R 2' together with R 3 forms a bond; R 3 is optionally substituted lower alkanoyl, or R 3 together with R 2' forms a bond; R 4 and R 5 are each hydrogen, optionally substituted lower alkanoyl or the like; R 6 is hydrogen or the like; and R 7 and R 8 are each hydrogen, optionally substituted lower alkanoyl or the like, with the proviso that LK6-A corresponding to a compound of general formula (I) where R 1 is (E)-methoxyacryloyl; R 2 , R 4 , R 5 , R 6 and R 7 are each hydrogen; R 8 is acetyl; and R 2' and R 3 together form a bond is excepted.

    摘要翻译： 具有通式（I）表示的LK6-A衍生物及其药理学上可接受的盐，其具有免疫抑制，细胞抑制和抗肿瘤作用等，其中R 1为低级烷酰基或丙烯酰基，其可被例如较低级 烷氧基等; R 2是氢，卤素等; R 2是氢，或R 2与R 3一起形成键; R 3是任选取代的低级烷酰基，或R 3与R 2'一起形成键; R 4和R 5各自为氢，任选取代的低级烷酰基等; R 6是氢等; R 7和R 8各自为氢，任选取代的低级烷酰基等，条件是对应于通式（I）的化合物的LK6-A，其中R 1为（E） - 甲氧基丙烯酰基 ; R 2，R 4，R 5，R 6和R 7各自为氢; R 8是乙酰基; 和R 2'和R 3一起形成键。