公开(公告)号：EP1867330A1

公开(公告)日：2007-12-19

申请号：EP06730570.6

申请日：2006-03-30

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： KAMIYA, Toshikazu c/o Healthcare Products Development Center ,  KIMURA, Masao c/o Healthcare Products Development Center ,  SAKAI, Yasushi c/o Healthcare Products Development Center

IPC分类号： A61K31/375 ,  A61K9/14 ,  A61K9/20 ,  A61K9/34 ,  A61K9/48 ,  A61K31/7084 ,  A61K47/18 ,  A61P3/02

CPC分类号： A61K9/2009 ,  A61K9/2013 ,  A61K9/2054 ,  A61K31/375 ,  A61K31/7084

摘要： The present invention relates to a method of improving storage stability of reduced form of nicotinamide adenine dinucleotide, reduced form of nicotinamide adenine dinucleotide phosphate, or a salt thereof, or ascorbic acid, an ascorbic acid derivative, or a salt thereof, which comprises allowing the substance to coexist with an L-arginine acidic amino acid salt, a composition containing the substance and an L-arginine acidic amino acid salt, a process for producing the composition, and a method of storing the substance in the presence of an L-arginine acidic amino acid salt.

摘要翻译： 本发明涉及一种改善烟酰胺腺嘌呤二核苷酸，还原型烟酰胺腺嘌呤二核苷酸磷酸酯或其盐或抗坏血酸，抗坏血酸衍生物或其盐的还原形式的储存稳定性的方法，其包括使 物质与L-精氨酸酸性氨基酸盐共存，含有该物质和L-精氨酸酸性氨基酸盐的组合物，该组合物的制造方法以及该物质在L-精氨酸存在下的存储方法 酸性氨基酸盐。

公开(公告)号：EP1941896A1

公开(公告)日：2008-07-09

申请号：EP06798143.1

申请日：2006-09-20

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： SAKAI, Yasushi c/o Healthcare Products Development Center ,  KIMURA, Masao c/o Healthcare Products Development Center ,  KAYAHASHI, Shun c/o Healthcare Products Development Center ,  KAMIYA, Toshikazu c/o Healthcare Products Development Center ,  HASHIMOTO, Shin-ichi c/o Technical Research Laboratories ,  KAWABE, Hideo c/o Head Office

IPC分类号： A61K38/00 ,  A23L1/305 ,  A61K9/08 ,  A61K9/16 ,  A61K9/20 ,  A61P3/02

CPC分类号： A61K9/2095 ,  A23L2/39 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/2018 ,  A61K9/2059 ,  A61K38/05 ,  A23V2200/316 ,  A23V2250/0628 ,  A23V2250/0654 ,  A23V2250/0626 ,  A23V2250/0604 ,  A23V2250/0622 ,  A23V2250/0606 ,  A23V2250/0642 ,  A23V2250/0608 ,  A23V2250/062

摘要： The present invention provides a composition for oral administration, which comprises at least one kind of dipeptide represented by the formula:

         X-Y

(wherein X represents alanyl, glycyl, arginyl, seryl, α-aspartyl or α-glutamyl, and Y represents valine, leucine or isoleucine), with an object of providing a composition for oral administration which is excellent in nutrition, pharmacological effect and gustation and comprises at least one kind selected from valine, leucine and isoleucine, or providing a composition for oral administration which is excellent in processing characteristics such as solubility and tableting property and comprises at least one kind selected from valine, leucine and isoleucine.

摘要翻译： 本发明提供口服给药组合物，其包含至少一种由下式表示的二肽：ƒ€ƒ€ƒ€ƒ€ƒƒXYƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒƒ 丝氨酰基，±天冬氨酰基或±谷氨酰基，Y代表缬氨酸，亮氨酸或异亮氨酸），其目的是提供口服给药组合物，其营养，药理作用和排气性优异，并且包含选自缬氨酸， 亮氨酸和异亮氨酸，或提供口服给药组合物，其加工特性如溶解度和压片性能优异，并且包含选自缬氨酸，亮氨酸和异亮氨酸中的至少一种。

公开(公告)号：EP1867713A1

公开(公告)日：2007-12-19

申请号：EP06730571.4

申请日：2006-03-30

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： KAMIYA, Toshikazu c/o Healthcare Products Development Center ,  KIMURA, Masao c/o Healthcare Products Development Center ,  SAKAI, Yasushi c/o Healthcare Products Development Center

IPC分类号： C12N1/04 ,  C12N1/14 ,  C12N1/16 ,  C12N1/20

CPC分类号： C12N1/04

摘要： The present invention relates to a method of improving storage stability of dried microorganisms, such as dried lactic acid bacteria, by allowing the dried microorganisms to coexist with an L-arginine acidic amino acid salt, a composition comprising dried microorganisms and an L-arginine acidic amino acid salt and a process for producing the same, and a method of storing dried microorganisms in the presence of an L-arginine acidic amino acid salt. The storage stability of dried microorganisms can be improved by allowing the dried microorganisms to coexist with an-L-arginine acidic amino acid salt.

摘要翻译： 本发明涉及通过使干燥的微生物与L-精氨酸酸性氨基酸盐共存，包含干燥的微生物的组合物和L-精氨酸的酸性化合物来提高干燥的微生物如干燥的乳酸菌的储存稳定性的方法 氨基酸盐及其制备方法，以及在L-精氨酸酸性氨基酸盐存在下储存干燥的微生物的方法。 通过使干燥的微生物与L-精氨酸酸性氨基酸盐共存，可以提高干燥微生物的储存稳定性。