公开(公告)号：EP3184107A1

公开(公告)日：2017-06-28

申请号：EP16199313.4

申请日：2003-06-19

申请人： N.V. Nutricia

发明人： HAGEMAN, Robert Johan Joseph ,  VERLAAN, George

IPC分类号： A61K31/195 ,  C07C257/10 ,  A23L33/17 ,  A23L33/00

CPC分类号： A61K45/06 ,  A23L33/115 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/195 ,  A61K38/16 ,  A61K2300/00 ,  A23V2250/0642 ,  A23V2200/308 ,  A23V2200/322 ,  A23V2200/324 ,  A23V2200/326 ,  A23V2200/328

摘要： The invention is concerned with a method and a composition for treating or preventing catabolism or of stimulating anabolism in a mammal undergoing metabolic stress. The method comprises administering to the mammal a composition containing methyl donors selected from the group consisting of L-serine, methionine, choline, phosphatidyl choline, betaine, dimethylglycine, sarcosine, methylated folates, S-adenosyl methionine, thymidine triphosphate, adenosine triphosphate and optionally methyl acceptors selected from the group consisting of L-glycine, ethanolamine, phosphatidyl ethanolamine, folate, ribose, wherein the total molar amount of methyl donors delivered by the method exceeds the total molar amount of methyl acceptors delivered by the method by at least 0.18 mmol per kg of body weight per day.

摘要翻译： 本发明涉及用于治疗或预防经历代谢应激的哺乳动物的分解代谢或刺激合成代谢的方法和组合物。 所述方法包括向哺乳动物施用包含选自L-丝氨酸，甲硫氨酸，胆碱，磷脂酰胆碱，甜菜碱，二甲基甘氨酸，肌氨酸，甲基化叶酸，S-腺苷甲硫氨酸，三磷酸胸苷，三磷酸腺苷和任选地 选自L-甘氨酸，乙醇胺，磷脂酰乙醇胺，叶酸盐，核糖的甲基受体，其中通过该方法递送的甲基供体的总摩尔量超过通过该方法递送的甲基受体的总摩尔量至少0.18mmol 每公斤体重每天。

公开(公告)号：EP2486808B1

公开(公告)日：2017-03-08

申请号：EP09850229.7

申请日：2009-10-06

申请人： Morinaga & Co., Ltd.

发明人： YANAE Koji ,  KAWAKAMI Shinpei ,  KATO Masatoshi ,  SETOGUCHI Yuko ,  SUGITANI Masanori

IPC分类号： A23F3/16 ,  A23L2/02 ,  A23L2/06 ,  A23L2/52 ,  A23L29/00 ,  A23L29/206 ,  A23L33/105 ,  A23L33/12

CPC分类号： A23L2/06 ,  A23F3/163 ,  A23L2/02 ,  A23L2/52 ,  A23L29/035 ,  A23L29/04 ,  A23L33/105 ,  A23L33/12 ,  A23V2002/00 ,  A23V2250/2132 ,  A23V2250/214 ,  A23V2250/21162 ,  A23V2250/0642 ,  A23V2250/061 ,  A23V2250/044 ,  A23V2250/1884

公开(公告)号：EP2341066B1

公开(公告)日：2015-05-20

申请号：EP09823618.5

申请日：2009-10-28

申请人： MG PHARMA INC.

发明人： KAGAWA, Kyoichi ,  FUKUHAMA, Chizuko ,  TONG, Chunning ,  SASAKAWA, Yuka

IPC分类号： C07K5/103 ,  A23K1/16 ,  A23L1/305 ,  A61K38/00 ,  A61P3/10 ,  A61P5/50

CPC分类号： A23K50/80 ,  A23F3/163 ,  A23K20/147 ,  A23K50/40 ,  A23L2/52 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/00 ,  C07K5/101 ,  A23V2200/326 ,  A23V2200/328 ,  A23V2250/0618 ,  A23V2250/0628 ,  A23V2250/0642

公开(公告)号：EP2486808A1

公开(公告)日：2012-08-15

申请号：EP09850229.7

申请日：2009-10-06

申请人： Morinaga & Co., Ltd.

发明人： YANAE Koji ,  KAWAKAMI Shinpei ,  KATO Masatoshi ,  SETOGUCHI Yuko ,  SUGITANI Masanori

IPC分类号： A23L1/305 ,  A23L2/52

CPC分类号： A23L2/06 ,  A23F3/163 ,  A23L2/02 ,  A23L2/52 ,  A23L29/035 ,  A23L29/04 ,  A23L33/105 ,  A23L33/12 ,  A23V2002/00 ,  A23V2250/2132 ,  A23V2250/214 ,  A23V2250/21162 ,  A23V2250/0642 ,  A23V2250/061 ,  A23V2250/044 ,  A23V2250/1884

摘要： Provided are a polyphenol compound absorption promoter which is widely applicable to foods and drinks over a wide range, and a method for producing a food, drink or food material containing a polyphenol compound. The polyphenol compound absorption promoter comprises, as the active ingredient, at least one member selected from the group consisting of serine, aspartic acid, malic acid, capric acid, lauric acid, grapefruit juice and Camellia sinensis (L.) O. Kuntze extract. The method for producing a food, drink or food material containing a polyphenol compound comprises: adding at least one member selected from the group consisting of serine, aspartic acid, malic acid, capric acid, lauric acid, grapefruit juice and Camellia sinensis (L.) O. Kuntze extract to a starting material for a food or drink or a starting material for a food material containing a polyphenol compound; or adding a polyphenol compound to a starting material for a food or drink or a starting material for a food material containing at least one member selected from the group consisting of serine, aspartic acid, malic acid, capric acid, lauric acid, grapefruit juice and Camellia sinensis (L.) O. Kuntze extract.

公开(公告)号：EP2467033A2

公开(公告)日：2012-06-27

申请号：EP10747527.9

申请日：2010-08-23

申请人： N.V. Nutricia

发明人： VAN NORREN, Klaske ,  PETERS, Johannes Adrianus Cornelis ,  LANSINK, Mirian

IPC分类号： A23L1/30 ,  A23L1/305 ,  A61K31/195 ,  A61K31/202

CPC分类号： A61K31/202 ,  A23L33/10 ,  A23L33/12 ,  A23L33/17 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A61K31/198 ,  A61K2300/00 ,  A23V2200/324 ,  A23V2250/0642 ,  A23V2250/0606 ,  A23V2250/0616 ,  A23V2250/0628 ,  A23V2250/0626 ,  A23V2250/0654 ,  A23V2250/1882 ,  A23V2200/304 ,  A23V2200/308

摘要： The present invention is directed at a combination of (i) serine, (ii) cysteine, (iii) arginine and (iv) at least one branched amino acid, for use in the therapeutic or prophylactic treatment of inflammation or infection, wherein the combination is to be administered enterally and at a combination of (i) serine, (ii) cysteine, (iii) arginine and (iv) at least one branched amino acid, for use in the therapeutic or prophylactic treatment of an imbalance in the metabolic use of amino acid resources from the body or from nutrition in a subject having an inflammation or an infection, wherein the combination is to be administered enterally.

公开(公告)号：EP2341066A4

公开(公告)日：2012-03-21

申请号：EP09823618

申请日：2009-10-28

申请人： MG PHARMA INC

发明人： KAGAWA KYOICHI ,  FUKUHAMA CHIZUKO ,  TONG CHUNNING ,  SASAKAWA YUKA

IPC分类号： C07K5/103 ,  A23K1/16 ,  A23L1/305 ,  A61K38/00 ,  A61P3/10 ,  A61P5/50

CPC分类号： A23K50/80 ,  A23F3/163 ,  A23K20/147 ,  A23K50/40 ,  A23L2/52 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/00 ,  C07K5/101 ,  A23V2200/326 ,  A23V2200/328 ,  A23V2250/0618 ,  A23V2250/0628 ,  A23V2250/0642

公开(公告)号：EP1941896A4

公开(公告)日：2010-01-27

申请号：EP06798143

申请日：2006-09-20

申请人： KYOWA HAKKO BIO CO LTD

发明人： SAKAI YASUSHI ,  KIMURA MASAO ,  KAYAHASHI SHUN ,  KAMIYA TOSHIKAZU ,  HASHIMOTO SHIN-ICHI ,  KAWABE HIDEO

IPC分类号： A61K38/00 ,  A23L1/305 ,  A61K9/08 ,  A61K9/16 ,  A61K9/20 ,  A61P3/02

CPC分类号： A61K9/2095 ,  A23L2/39 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/2018 ,  A61K9/2059 ,  A61K38/05 ,  A23V2200/316 ,  A23V2250/0628 ,  A23V2250/0654 ,  A23V2250/0626 ,  A23V2250/0604 ,  A23V2250/0622 ,  A23V2250/0606 ,  A23V2250/0642 ,  A23V2250/0608 ,  A23V2250/062

公开(公告)号：EP1660097B1

公开(公告)日：2009-02-04

申请号：EP04764814.2

申请日：2004-09-03

申请人： Cargill Texturizing Solutions Deutschland GmbH & Co KG

发明人： PURPURA, Martin ,  JÄGER, Ralf ,  RABELER, Roland ,  HOPPE, Hans-Ullrich

IPC分类号： A61K31/685 ,  A61K31/683 ,  A61K31/661

CPC分类号： A61K31/661 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/683 ,  A61K31/685 ,  A61K2300/00 ,  A23V2250/1852 ,  A23V2250/1842 ,  A23V2250/0642 ,  A23V2250/1868

摘要： The invention relates to a physiologically active composition containing the following as physiologically active constituents: a) phosphatidylserine and/or lyso-phosphatidylserine (respectively PS'), b) at least one (lyso-)phospholipid that is different from constituent a), and c) a serine source that is different from constituent a), such as L-serine and/or O-phospho-L-serine. Said constituents a), b) and c) must respectively be in such a molar ratio a: b (where b

公开(公告)号：EP1757289A4

公开(公告)日：2007-08-08

申请号：EP05734453

申请日：2005-04-19

申请人： KIRIN BREWERY

发明人： KATAYAMA YUMIKO ,  YOSHIDA ARUTO

IPC分类号： A61K31/405 ,  A23L1/30 ,  A23L1/305 ,  A23L2/52 ,  A61K31/197 ,  A61K31/198 ,  A61K31/401 ,  A61K31/522 ,  A61K38/00 ,  A61K38/02 ,  A61K45/06 ,  A61P3/00 ,  A61P3/02 ,  A61P3/08 ,  A61P7/10 ,  A61P17/16 ,  A61P19/06 ,  A61P25/02 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P29/00 ,  A61P39/02 ,  A61P43/00 ,  C07D209/20 ,  C07D473/12

CPC分类号： A61K9/0095 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A61K31/197 ,  A61K31/198 ,  A61K31/405 ,  A61K31/522 ,  A61K38/02 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/2108 ,  A23V2250/065 ,  A23V2250/0642

摘要： A composition that through safe intake of active ingredients, is useful for reducing a burden on body at alcohol ingestion and for recuperation from fatigue. There is provided a composition for acceleration of alcohol metabolism or recuperation from fatigue through gluconeogenesis within the body, characterized by containing, as active ingredients, an effective amount of caffeine and an effective amount of amino acid or peptide selected from the group consisting of serine, tryptophan, a peptide with a high content of serine, a peptide with a high content of tryptophan, a peptide with a high content of serine/tryptophan and mixtures thereof.

公开(公告)号：EP1455602B1

公开(公告)日：2006-03-08

申请号：EP02792103.0

申请日：2002-12-20

申请人： DSM IP Assets B.V.

发明人： VERHOEF, Petra ,  VAN DER MEER, Roelof

IPC分类号： A23L1/305 ,  A23C9/13 ,  A23C19/09 ,  A23L1/314

CPC分类号： A23C19/0921 ,  A23C9/1322 ,  A23L13/428 ,  A23L15/30 ,  A23L33/15 ,  A23L33/175 ,  A23V2002/00 ,  A23V2250/0616 ,  A23V2250/0642 ,  A23V2250/7052

摘要： The present invention relates to methionine rich food products that have been modified so as to reduce their boosting effect on serum homocysteine concentration. More particularly, the invention is concerned with food products comprising at least 5% proteinaceous matter by weight of dry matter, wherein at least 50% of the proteinaceous matter is of animal origin or derived from seeds, nuts, grain or pulses, and wherein the amino acid profile of the food products has been altered to contain elevated amounts of cysteine, and optionally serine. Typically, the present food products contain the amino acids cysteine [Cys] and methionine [Meth] in a molar ratio which meets the following equation: [Cys] / [Meth] ≥2:1. Another aspect of the invention relates to the use of the aformentioned food products in a method of treating or preventing elevated plasma concentrations of homocysteine. Yet another aspect of the invention is concerned with a method of modifying a methionine rich food product by incorporating therein a source of cysteine, and optionally a source of serine.