公开(公告)号：EP1270642A1

公开(公告)日：2003-01-02

申请号：EP00985846.5

申请日：2000-12-22

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： YAMASAKI, Motoo, c/o Tokyo Research Laboratories ,  SUZAWA, Toshiyuki, c/o Tokyo Research Laboratories ,  MURAKAMI, Tatsuya, c/o Tokyo Research Laboratories ,  SAKURAI, Noriko, c/o Tokyo Research Laboratories ,  YAMASHITA, Kinya, Pharm. Res. Inst., Kyowa Hakko ,  MUKAI, Mayumi, Pharm. Res. Inst., Kyowa Hakko ,  KUWABARA, Takashi, Pharm. Res. Inst., Kyowa Hakko ,  OHTA, So, c/o Pharm. Res. Inst., Kyowa Hakko ,  MIKI, Ichiro, Pharm. Res. Inst., Kyowa Hakko

IPC分类号： C08G65/337 ,  A61K38/21 ,  A61K47/48 ,  A61P21/00

CPC分类号： C08G65/329 ,  A61K38/215 ,  A61K47/60 ,  A61K47/65 ,  A61K47/6889 ,  C08L2203/02

摘要： The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure.

摘要翻译： 本发明提供可用作生理活性多肽的化学改性剂的支链聚亚烷基二醇，其中两个单链聚亚烷基二醇与除了平面结构之外的环状结构的基团连接，并且其中与氨基酸具有反应性的基团 侧链，多肽中的N-末端氨基或C-末端羧基或可转化成具有反应性的基团的基团与具有除了平面结构以外的结构的基团连接。