公开(公告)号：EP1666064A1

公开(公告)日：2006-06-07

申请号：EP04772374.7

申请日：2004-08-23

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： SHIOTSU, Yukimasa, c/o Kyowa Hakko Kogyo Co.,Ltd., ,  SOGA, Shiro ,  KANDA, Yutaka, c/o Kyowa Kakko Kogyo Co., Ltd., ,  AKINAGA, Shiro, c/o Kyowa Kakko Kogyo Co., Ltd.,

IPC分类号： A61K45/00 ,  A61K31/365 ,  A61P35/02

CPC分类号： A61K31/365 ,  A61K31/00 ,  C07D313/00

摘要： A medicament comprising a compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof as an active ingredient is used as a therapeutic agent for diseases associated with immunoglobulin gene translocations. In diseases associated with immunoglobulin gene translocations, abnormal enhancement of the expression of a partner gene in immunoglobulin gene translocation participates in the development of the diseases and the progress of the symptoms. By administering the compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof, degradation of protein encoded by the partner gene is promoted and the diseases can be treated.

摘要翻译： 将包含对Hsp90或其药学上可接受的盐具有抑制作用的化合物作为活性成分的药物用作与免疫球蛋白基因易位相关的疾病的治疗剂。 在与免疫球蛋白基因易位相关的疾病中，免疫球蛋白基因易位中伴侣基因表达的异常增强参与了疾病的发展和症状的进展。 通过施用对Hsp90具有抑制作用的化合物或其药学上可接受的盐，促进由伴侣基因编码的蛋白质的降解，并且可以治疗疾病。