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    UCF1 compounds derivatives thereof and processes for their preparation
    2.
    发明公开
    UCF1 compounds derivatives thereof and processes for their preparation 失效
    UCF1 Verbindungen，deren Derivate und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0456474A1

    公开(公告)日：1991-11-13

    申请号：EP91304128.1

    申请日：1991-05-08

    申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

    发明人： Nakano, Hirofumi ,  Hara, Mitsunobu ,  Saito, Yutaka ,  Ikuina, Yoji ,  Takiguchi, Toshimitsu ,  Okabe, Masami

    IPC分类号： C07D303/36 ,  C12P17/02 ,  C12N1/20

    CPC分类号： C12R1/465 ,  C07D303/36 ,  C07D303/46 ,  C12P17/02

    摘要： Compounds UCF1 and derivatives thereof exhibit anti-bacterial and anti-tumour activities and may be used for the preparation of anti-bacterial and anti-tumour agents.
    Compounds UCF1 may be produced by fermentation of a microorganism of the genus Streptomyces capable of producing compounds UCF1, preferably Streptomyces sp. UOF1 (FERM BP-2844) and recovering the desired compounds from the cultured broth.
    The compounds UCF1 have the formula

    [wherein R represents either

    or

    The compounds may be oxidised to obtain derivatives of formula

    which exhibit similar pharmacological activities.

    摘要翻译： 化合物UCF1及其衍生物表现出抗细菌和抗肿瘤活性，可用于制备抗细菌和抗肿瘤剂。 化合物UCF1可以通过发酵能产生化合物UCF1，优选链霉菌属（Streptomyces sp。）的链霉菌属的微生物来生产。 UOF1（FERM BP-2844）并从培养液中回收所需化合物。 化合物UCF1具有式 [其中R表示或。化合物可以被氧化以获得具有相似药理活性的式的衍生物。