公开(公告)号：EP3283062A1

公开(公告)日：2018-02-21

申请号：EP16780757.7

申请日：2016-04-14

申请人： Hawaii Biotech, Inc.

发明人： JOHNSON, Alan Thomas ,  KIM, Seong Jin ,  O'MALLEY, Sean ,  JACKSON, Henry Lee

IPC分类号： A61K31/16 ,  A61K31/165 ,  C07C259/06

CPC分类号： C07C259/06 ,  C07C259/10 ,  C07C2601/02 ,  C07D207/337 ,  C07D211/34 ,  C07D213/56 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D239/42 ,  C07D295/155 ,  C07D295/16 ,  C07D295/185 ,  C07D295/205 ,  C07D303/46

摘要： R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

公开(公告)号：EP2662395A3

公开(公告)日：2015-03-04

申请号：EP13165059.0

申请日：2013-04-24

申请人： LG Innotek Co., Ltd.

发明人： Park, Jae Man ,  Kim, Hae Yeon ,  Moon, SungBae ,  Park, Jeungook ,  Yun, SungJin ,  Yoon, JongHeum ,  Lee, Hyuk Soo ,  Jeong, Jaehun ,  Cho, In Hee

IPC分类号： C08G59/28 ,  C08L63/00 ,  C07D303/46 ,  H05K1/05

CPC分类号： C08L63/00 ,  C07D303/46 ,  C08G59/28 ,  H05K1/05

摘要： An epoxy resin compound including an epoxy resin, a hardening agent, and an inorganic filler as a main component is provided. The epoxy resin includes an epoxy resin represented by a chemical formula. Therefore, the epoxy resin having a mesogen structure that increases crystallinity is used, and thus thermal conductivity can be increased. Further, the epoxy resin is used as an insulating material for a printed circuit board, and thus a high radiant heat substrate can be provided.

公开(公告)号：EP2729456A1

公开(公告)日：2014-05-14

申请号：EP12732670.0

申请日：2012-07-06

申请人： DSM IP Assets B.V.

发明人： ALSTERS, Paulus Lambertus ,  IJPEIJ, Edwin Gerard

IPC分类号： C07D301/12 ,  C07D303/38 ,  C07C255/12

CPC分类号： C07C255/16 ,  C07C253/30 ,  C07D301/12 ,  C07D303/38 ,  C07D303/46 ,  C07C255/12 ,  C07C255/14

摘要： The invention relates to novel nitrile compounds according to formula I and II: (I) Formula I wherein: X = -CH
3 or -C≡N, (II) Formula II wherein: X = -CH
3 or -C≡N, each Y is independently chosen from -OH or RC(0)0-, each R is independently chosen from a C1 -21 alkyl group. The invention also relates to processes for the preparation of nitrile compounds according to formula I and II and to uses of the nitrile compounds.

摘要翻译： 本发明涉及式I和II的新型腈化合物：（I）式I其中：X = -CH 3或-C≡N，（II）式II其中：X = -CH 3或-C≡N，各Y 独立地选自-OH或RC（O）O-，每个R独立地选自C 1-12烷基。 本发明还涉及制备根据式I和II的腈化合物和腈化合物的用途的方法。

公开(公告)号：EP2289887A3

公开(公告)日：2011-07-06

申请号：EP10011260.6

申请日：2001-06-29

申请人： SEIKAGAKU CORPORATION

发明人： Kobayashi, Nubuo ,  Koji, Tsuneo ,  Fujita, Takashi ,  Nishimura, Tomofumi ,  Hosoda, Akihiko

IPC分类号： C07D303/48 ,  C07D295/20 ,  C07D317/66 ,  C07D207/16 ,  C07C247/12 ,  C07C237/22 ,  C07C271/22 ,  C07C231/12 ,  C07C231/16

CPC分类号： C07D295/215 ,  C07C231/12 ,  C07C231/16 ,  C07C237/22 ,  C07C247/12 ,  C07C271/22 ,  C07C2601/14 ,  C07D207/16 ,  C07D295/18 ,  C07D303/46 ,  C07D303/48 ,  C07D317/66 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12

摘要： The present invention is to provide manufacturing intermediates which can be led to useful α-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide azide compounds represented by the following formula:

wherein R 1 and R 2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; and processes for preparing α-keto amide compound using the same.

摘要翻译： 本发明的目的在于提供能够非常经济且立体地选择性地得到具有蛋白酶抑制活性的有用的α-酮酰胺化合物的制造中间体，并且提供下式所示的叠氮化合物：其中R1和R2各自表示烷基，烯基 ，芳族烃基或杂环基团; 以及使用其制备α-酮酰胺化合物的方法。

公开(公告)号：EP1773757A1

公开(公告)日：2007-04-18

申请号：EP05770295.3

申请日：2005-07-06

申请人： INDENA S.p.A.

发明人： MORAZZONI, Paolo, Indena S.p.A. ,  RIVA, Antonella, Indena S.p.A. ,  FONTANA, Gabriele, Indena S.p.A. ,  APPENDINO, Giovanni, DSCAF, Uni Piemonte Orient ,  DI MARZO, Vincenzo, Istituto Chimica Biom CNR

IPC分类号： C07C235/28 ,  C07C235/26 ,  C07D303/46 ,  A61K31/16 ,  A61P25/00 ,  A61P13/00

CPC分类号： C07C235/28 ,  C07C235/26 ,  C07D303/46

摘要： The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene; R2 is a C6-C12 aryl, or arylalkyl residue; R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.

公开(公告)号：EP1553074A1

公开(公告)日：2005-07-13

申请号：EP03788076.2

申请日：2003-08-11

申请人： Takeda Pharmaceutical Company Limited

发明人： SHIRAISHI, Mitsuru ,  HARA, Takahito ,  KUSAKA, Masami ,  KANZAKI, Naoyuki ,  YAMAMOTO, Satoshi ,  MIYAWAKI, Toshio

IPC分类号： C07C35/52 ,  C07C255/52 ,  C07C255/53 ,  C07C255/56 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/22 ,  C07D207/24 ,  C07D209/44 ,  C07D211/14

CPC分类号： C07C255/52 ,  C07C35/52 ,  C07C217/04 ,  C07C255/53 ,  C07C255/54 ,  C07C255/56 ,  C07C2601/08 ,  C07C2601/10 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/22 ,  C07D207/24 ,  C07D209/46 ,  C07D211/22 ,  C07D211/28 ,  C07D211/34 ,  C07D211/42 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D211/74 ,  C07D231/08 ,  C07D261/04 ,  C07D265/02 ,  C07D267/10 ,  C07D295/073 ,  C07D295/112 ,  C07D295/155 ,  C07D303/46 ,  C07D307/79 ,  C07D333/54 ,  C07D405/04 ,  C07D409/04 ,  C07D491/10

摘要： The present invention provides a compound represented by the general formula:
[wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X 1 represents carbon atom, X 2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y 11 represents a group represented by the formula CR 2 R 3' (wherein R 2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R 3' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y 21 represents a group represented by the formula CR 4 R 5' (wherein R 4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R 5' represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R 1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.

摘要翻译： 本发明提供由以下通式表示的化合物：其中环A表示任选取代的5至8元环，环B表示另外任选取代的4-至10-元环，环C表示另外 任选取代的苯环，X 1表示碳原子，X 2表示碳原子，氧原子等，W表示氮原子等，Y 11表示由式CR表示的基团 R 3（其中R 2表示氢原子，氰基，硝基等），R 3表示氢原子，氰基，硝基等 ，Y 21表示由式CR 4 R 5表示的基团（其中R 4表示氢原子，氰基，硝基等） 5'分别表示氢原子，氰基，硝基等）等，R 1分别表示吸电子基团。 该式表示单键或双键或其盐，其可用作雄激素受体调节剂。

公开(公告)号：EP0983236A2

公开(公告)日：2000-03-08

申请号：EP98919377.6

申请日：1998-05-01

申请人： Avecia Limited ,  THE UNIVERSITY OF SHEFFIELD

发明人： STUDLEY, John, Richard ,  AGGARWAL, Varinder, Kumar

IPC分类号： C07D203/24 ,  C07D203/22 ,  C07D301/02 ,  C07C13/04

CPC分类号： C07D303/22 ,  C07D203/02 ,  C07D301/02 ,  C07D303/04 ,  C07D303/08 ,  C07D303/46 ,  C07D327/06 ,  C07D333/54 ,  C07D333/78 ,  C07D405/04 ,  C07D495/08 ,  Y10S436/903

摘要： A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I) wherein X is oxygen, NR?4 or CHR5; R1¿ is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R2 is hydrogen, alkyl, aryl, heteroaromatic, CO¿2?R?8, CHR14NHR13¿, heterocyclic or cycloalkyl; or R?1 and R2¿ join together to form a cycloalkyl ring; R?3 and R10¿ are, independently, hydrogen, alkyl, aryl, heteroaromatic, CO¿2R?8, R83Sn, CONR8R9, trialkylsilyl or triarylsilyl; R4 is an electron withdrawing group; R5 is alkyl, cycloalkyl, aryl, heteroaromatic, SO¿2R?8, SO3R?8, COR8, CO¿2R?8, CONR8R9, PO(R8)¿2, PO(OR8)2 or CN; R?8 and R9¿ are independently alkyl or aryl; and R?13 and R14¿ are independently hydrogen, alkyl or aryl is provided. The process comprises degrading a compound of the formula (II), (IIa), (IIb) or (IIc), wherein R?3 and R10¿ are as defined above; Y is a cation; depending on the nature of Y, r is 1 or 2; and L is a suitable leaving group, to form a diazo compound. The diazo compound is reacted with a suitable transition metal catalyst, and the product thereof reacted with a sulphide of the formula SR6R7, wherein R?6 and R7¿ are independently alkyl, aryl or heteroaromatic, or R?6 and R7¿ join together to form an optionally substituted ring which optionally includes an additional heteroatom. This product is then reacted with an aldehyde, ketone, imine or alkene.

公开(公告)号：EP0861838A2

公开(公告)日：1998-09-02

申请号：EP98301367.3

申请日：1998-02-25

申请人： ELI LILLY AND COMPANY ,  UNIVERSITY OF HAWAII ,  Wayne State University

发明人： Patel, Vinod Francis ,  Hoard, David Warren ,  Moher, Eric David

IPC分类号： C07D413/06 ,  C07D419/06 ,  C07D303/46 ,  C07D303/38 ,  C07D303/40 ,  C07D405/12 ,  C07F7/18 ,  C07C271/22

CPC分类号： C07D303/38 ,  C07D303/40 ,  C07D303/46 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  Y02P20/55

摘要： Cryptophycin compounds may be prepared utilizing an epoxidation step early in the synthetic process under the conditions set forth herein. This invention also relates to novel intermediates generated by this early epoxidation process.

摘要翻译： 在本文所述的条件下，可以在合成过程的早期利用环氧化步骤制备隐藻菌素化合物。 本发明还涉及由这种早期环氧化过程产生的新型中间体。

公开(公告)号：EP0770606A1

公开(公告)日：1997-05-02

申请号：EP95119846.4

申请日：1995-12-15

申请人： LG Chemical Limited

发明人： Kim, Sung-Chun ,  Son, Young-Chan, Hanmaru Apt. 10-403, 16th BL ,  Choi, Ho-Il ,  Yoon, Heung-Sik ,  Park, Chi-Hyo ,  Choy, Nakyen ,  Lee, Chang-Sun, ,  Koh, Jong-Sung ,  Moon, Kwang-Yul ,  Jung, Won-Hee ,  Kim, Chung-Ryeol

IPC分类号： C07D303/46 ,  C07D301/14 ,  C07D301/19 ,  A61K31/335

CPC分类号： C07D303/46

摘要： The present invention relates to a novel compound of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof which is an irreversible HIV protease inhibitor; a process for the preparation thereof; and a pharmaceutical composition containing the compound as an active ingredient which is useful for treating or preventing diseases caused by HIV infection.

摘要翻译： 本发明涉及新的式（I）化合物及其药学上可接受的盐，水合物和溶剂化物，其是不可逆的HIV蛋白酶抑制剂; 其制备方法; 以及含有该化合物作为活性成分的药物组合物，其可用于治疗或预防由HIV感染引起的疾病。

公开(公告)号：EP0629609B1

公开(公告)日：1996-12-04

申请号：EP94111766.5

申请日：1990-05-16

申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

发明人： Hayase, Yoshio ,  Kataoka, Takahiro ,  Takenaka, Hideyuki ,  Ichinari, Mitsuhiro ,  Masuko, Michio ,  Takahashi, Toshio ,  Tanimoto, Norihiko

IPC分类号： C07C249/12 ,  C07C251/48 ,  C07D213/64 ,  C07D239/34 ,  C07D251/22 ,  A01N37/50

CPC分类号： C07C249/12 ,  A01N37/50 ,  C07C251/48 ,  C07C317/44 ,  C07C323/60 ,  C07D213/64 ,  C07D215/227 ,  C07D239/34 ,  C07D277/68 ,  C07D303/46 ,  C07D307/36 ,  C07D307/40 ,  C07D307/42 ,  C07D309/12 ,  C07F7/10