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1.发明公开METHOD FOR SEARCHING STEROID SULFATASE INHIBITORS 审中-公开VERFAHREN ZUR AUFFINDUNG VON STEROID SULFATASEHEMMENDE VERBINDUNGEN
公开(公告)号：EP1065281A4
公开(公告)日：2004-08-18
申请号：EP99910718
申请日：1999-03-26
申请人： KYOWA HAKKO KOGYO KK
发明人： ANAZAWA HIDEHARU , KATO YOKO , ISHIDA HIROYUKI , NAKATA TAISUKE , AKINAGA SHIRO
CPC分类号： C12Q1/34 , A01K2217/05 , C12N9/16 , G01N33/5011
摘要： A method for efficiently searching compounds capable of inhibiting steroid sulfatase activity and thus being useful in treating hormone-dependent diseases such as mammary cancer which comprises treating cells having a steroid sulfatase gene transferred thereinto with the compounds to be tested and then judging the proliferation of the cells.
摘要翻译： 一种有效地检索能够抑制类固醇硫酸酯酶活性的化合物的方法，因此可用于治疗激素依赖性疾病如乳腺癌，该方法包括用待测化合物处理其中转移有类固醇硫酸酯酶基因的细胞，然后判断 细胞。
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公开(公告)号：EP0960934A4
公开(公告)日：2003-09-03
申请号：EP97942199
申请日：1997-09-25
发明人： NAGASHIMA TADASHI , KUROYANAGI SATOSHI , YAMAMURA TADANORI , ANAZAWA HIDEHARU , KATO YOKO , SUGIMOTO SEIJI , YANO KEIICHI
CPC分类号： C12N9/16 , A23K20/189 , Y10S426/807
摘要： A phytase having a low Km value against phytic acid; a process for the preparation of the phytase by using a microorganism having the ability to generate and accumulate the phytase; and feed containing the phytase. The novel phytase can hydrolyze phytic acid (acting as antinutritional factor) contained in feed, which brings about an enhancement in the nutritive value of the feed, and permits the efficient utilization of phosporic acid liberated by the hydrolysis.
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公开(公告)号：EP0811691A4
公开(公告)日：2000-01-05
申请号：EP96930357
申请日：1996-09-11
申请人： KYOWA HAKKO KOGYO KK
发明人： KOIKE MASAMICHI , FURUYA AKIKO , NAKAMURA KAZUYASU , IIDA AKIHIRO , ANAZAWA HIDEHARU , HANAI NOBUO , TAKATSU KIYOSHI
IPC分类号： A61K38/00 , C07K14/715 , C07K16/24 , C07K16/28 , C12N5/18 , C12P21/08 , C12N5/20 , C12N15/06 , C12N15/09 , C12N15/63 , C12N15/85 , G01N33/53 , G01N33/577
CPC分类号： C07K16/2866 , A61K38/00 , A61K2039/505 , C07K14/7155 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C12N2799/026
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公开(公告)号：EP1325959A4
公开(公告)日：2005-05-25
申请号：EP01945681
申请日：2001-06-28
IPC分类号： C07K14/37 , C12N1/19 , C12N15/80 , C12N9/04 , C12N9/06 , C12N9/14 , C12N9/16 , C12N9/36 , C12N15/11
摘要： A novel DNA encoding a selection marker and a novel DNA serving as a promoter/terminator which are appropriate for a transformation system of a fungus belonging to the genus Monascus and the expression of a recombinant DNA; and a novel transformation system of a fungus belonging to the genus Monascus wherein the monascus is transformed by a vector containing the above-described DNA encoding a selection marker and the promoter/terminator sequence together with a DNA encoding a desired protein, culturing the resultant transformant and thus obtaining the expression product of the recombinant DNA at a high level.
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公开(公告)号：EP0783003A4
公开(公告)日：1998-01-07
申请号：EP96912262
申请日：1996-04-26
申请人： KYOWA HAKKO KOGYO KK
发明人： YOKOI HARUHIKO , SHIOTSU YUKIMASA , KONISHI NOBORU , ANAZAWA HIDEHARU , TAMAOKI TATSUYA , YAMASAKI MOTOO , TERASAKI YOKO , UCHIDA KAZUHISA , YAMASHITA KINYA
CPC分类号： C07K14/535 , A61K38/00 , C07K14/52 , C07K14/524 , C07K2319/00
摘要： A fused polypeptide composed of a polypeptide having the G-CSF activity with another polypeptide having the TPO activity; a DNA encoding this fused polypeptide; a fused polypeptide wherein a polypeptide having the G-CSF activity has been fused with another polypeptide having the TPO activity via a spacer peptide; a DNA encoding this fused polypeptide; a polypeptide wherein the above-mentioned fused polypeptide composed of the polypeptide having the G-CSF activity with the polypeptide having the TPO activity has been further chemically modified with a polyalkylene glycol derivative; and a remedy for anemia containing such a fused polypeptide as the active ingredient.
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6.发明公开
公开(公告)号：EP1176195A4
公开(公告)日：2005-03-02
申请号：EP00915403
申请日：2000-04-07
申请人： KYOWA HAKKO KOGYO KK
发明人： HANAI NOBUO , NAKAMURA KAZUYASU , HOSOKA EMI , YAMASAKI MOTOO , UCHIDA KAZUHISA , SHINKAWA TOYOHIDE , IMABEPPU SUSUMU , KANDA YUTAKA , YAMANE NAOKO , ANAZAWA HIDEHARU
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , C07K16/46 , C12P21/08 , G01N33/53 , C12N15/09 , A61K39/00 , C12P21/00
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
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公开(公告)号：EP0955362A4
公开(公告)日：2002-08-14
申请号：EP97914613
申请日：1997-04-04
CPC分类号： C12N9/16 , A23K20/189 , C12Y301/03008 , Y10S435/913 , Y10S435/917
摘要： A phytase that has a low Km value with respect to phytic acid and is inexpensive; a DNA encoding the phytase; a recombinant DNA comprising the above DNA integrated thereinto; a transformant having the recombinant DNA; a process for producing the phytase by using the transformant; and a feed prepared by using the phytase.
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8.发明公开
公开(公告)号：EP0989136A4
公开(公告)日：2002-10-09
申请号：EP98919612
申请日：1998-05-15
申请人： KYOWA HAKKO KOGYO KK
发明人： SHIBATA KENJI , YAMASAKI MOTOO , YOSHIDA TETSUO , MIZUKAMI TAMIO , SHINKAI AKEO , ANAZAWA HIDEHARU
CPC分类号： C07K7/08 , A61K38/00 , C07K7/52 , C07K7/64 , C07K14/4746
摘要： Peptides having cyclic structures represented by the following general formula (I): R (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) (X ) R and exerting the effect of restoring a P53 protein activity on P53 protein mutants or pharmacologically acceptable salts thereof. In said formula (I) X means an arbitrary member selected from among X to X while n means an arbitrary member selected from among n to n (provided that i is an integer of from 1 to 17), then X represents an amino acid residue or an organic acid residue; a functional group in a residue X selected among X to X (provided that p is an integer of from 1 to 11) and a functional group X selected from among X to X (provided that q is an integer of from 8 to 17 and larger than p) form a cyclic structure having a crosslinkage selected from among S-S, S-CH2-S, S-CH2-C6H4-CH2-S, S-CH2-CO, CO-NH, NH-CO, O-CO or CO-O; R represents optionally substituted alkanoyl, etc.; and R represents optionally substitued alkoxy, etc.
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公开(公告)号：EP0990701A4
公开(公告)日：2001-12-12
申请号：EP99910727
申请日：1999-03-26
申请人： KYOWA HAKKO KOGYO KK
发明人： HANAI NOBUO , YAMASAKI MOTOO , SHIBATA KENJI , FURUYA AKIKO , MIKUNI OSAMU , ANAZAWA HIDEHARU
IPC分类号： C07K16/40 , C12N15/06 , C12P21/08 , G01N33/573 , A61K39/395 , C12N5/18 , C12N15/13 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/569
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/624 , G01N33/573
摘要： A monoclonal antibody capable of specifically and effectively recognizing hTERT protein which is the catalytic subunit of telomerase; a human chimeric antibody, a CDR transplantation antibody, a single-stranded antibody and a disulfide stabilizing antibody each containing the above monoclonal antibody; a method for detecting/quantitating hTERT protein by using these antibodies; and diagnostic methods, diagnostics and remedies for various diseases such as cancer in which telomerase participates.
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