公开(公告)号：EP1449850A4

公开(公告)日：2005-08-10

申请号：EP02770179

申请日：2002-08-30

申请人： KYOWA HAKKO KOGYO KK

发明人： SHITARA KENYA ,  NAKAMURA KAZUYASU ,  HOSAKA EMI ,  SHIMIZU AKIKO ,  KOIKE MASAMICHI

IPC分类号： B65H31/30 ,  A61K39/395 ,  A61P35/00 ,  B65H31/24 ,  B65H31/26 ,  B65H31/36 ,  B65H37/04 ,  C07K14/715 ,  C07K16/28 ,  C12N5/10 ,  C12N15/13 ,  C12P21/08 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K14/7158 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/732 ,  G01N33/57492 ,  G01N33/6863 ,  G01N2333/4719 ,  G01N2333/7158

摘要： A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.