公开(公告)号：EP1449850A4

公开(公告)日：2005-08-10

申请号：EP02770179

申请日：2002-08-30

申请人： KYOWA HAKKO KOGYO KK

发明人： SHITARA KENYA ,  NAKAMURA KAZUYASU ,  HOSAKA EMI ,  SHIMIZU AKIKO ,  KOIKE MASAMICHI

IPC分类号： B65H31/30 ,  A61K39/395 ,  A61P35/00 ,  B65H31/24 ,  B65H31/26 ,  B65H31/36 ,  B65H37/04 ,  C07K14/715 ,  C07K16/28 ,  C12N5/10 ,  C12N15/13 ,  C12P21/08 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K14/7158 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/732 ,  G01N33/57492 ,  G01N33/6863 ,  G01N2333/4719 ,  G01N2333/7158

摘要： A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.

公开(公告)号：EP1767627A4

公开(公告)日：2007-07-25

申请号：EP05749067

申请日：2005-06-07

申请人： KYOWA HAKKO KOGYO KK ,  JAPAN GOVERNMENT

发明人： OCHIAI ATSUSHI ,  SHIRAISHI NORIHIKO ,  KATO YOKO ,  OTA TOSHIO ,  SEKINE SUSUMU ,  SHITARA KENYA ,  FURUYA AKIKO ,  OHTA SO ,  HOSAKA EMI ,  SASAKI YUKA

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  G01N33/53 ,  G01N33/574

CPC分类号： G01N33/57492 ,  C07K16/28 ,  C07K2317/732 ,  C07K2317/734

摘要： It is intended to provide an antibody which specifically recognizes the stereostructure of the extracellular domain of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular domain. This antibody is useful in treating various diseases associated with the overexpression of the polypeptide encoded by PERP gene. Furthermore, this antibody makes it possible to specifically detect the polypeptide encoded by PERP gene or a cell expressing this polypeptide by an immunological procedure and, therefore, is useful in diagnosing various diseases in which PERP participates.

摘要翻译： 旨在提供一种特异性识别由PERP（PMP-22相关的p53凋亡效应子）基因编码的多肽的胞外结构域的立体结构并与细胞外结构域结合的抗体。 该抗体可用于治疗与由PERP基因编码的多肽的过表达有关的各种疾病。 此外，该抗体可以通过免疫学方法特异性检测由PERP基因编码的多肽或表达该多肽的细胞，因此可用于诊断PERP参与的各种疾病。

公开(公告)号：EP1331266A4

公开(公告)日：2005-07-13

申请号：EP01974718

申请日：2001-10-05

申请人： KYOWA HAKKO KOGYO KK

发明人： KANDA YUTAKA ,  SATOH MITSUO ,  NAKAMURA KAZUYASU ,  UCHIDA KAZUHISA ,  SHINKAWA TOYOHIDE ,  YAMANE NAOKO ,  HOSAKA EMI ,  YAMANO KAZUYA ,  YAMASAKI MOTOO ,  HANAI NOBUO

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C12N5/10 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12P21/00 ,  C12P21/08 ,  C12N15/10 ,  A01K67/00 ,  C12N9/00 ,  C12N15/52 ,  G01N33/53

CPC分类号： C07K16/3084 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/065 ,  C07K16/18 ,  C07K16/2866 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/1241 ,  C12N9/90 ,  C12P21/005

摘要： Cells to be used in producing antibody compositions, for example, an antibody having a high antibody-dependent cellular cytotoxic activity which is useful in various diseases, an antibody fragment or a fused protein having the Fc domain of the antibody; a process for producing an antibody composition by using these cells; antibody compositions; and uses thereof. In the above-described antibody compositions, the ratio of sugar chains, which are free from fucose bonded to N-acetylglucosamine at the sugar chain reducing end, to the total N-glycoside linkage complex sugar chains bonded to the Fc domain amounts to 20% or more. Moreover, novel GDP-mannose 4,6-dehydrogenase, GDP-keto-6-deoxymannose 3,5-epimerase 4-reductase, GDP-beta-L-fucose pyrophosphorylase, alpha-1,6-fucosyltransferase and DNAs encoding the same are provided.

公开(公告)号：EP1688439A4

公开(公告)日：2007-12-19

申请号：EP04773776

申请日：2004-10-08

申请人： KYOWA HAKKO KOGYO KK

发明人： SHITARA KENYA ,  HOSAKA EMI ,  NATSUME AKITO ,  WAKITANI MASAKO ,  UCHIDA KAZUHISA ,  SATO MITSUO ,  OHNUKI NAOKO ,  NAKAMURA KAZUYASU

IPC分类号： A61K38/17 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07K14/705 ,  C07K14/715 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N5/10 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/62 ,  C12P21/08

CPC分类号： C07K16/30 ,  A61K38/00 ,  C07K14/70528 ,  C07K14/7151 ,  C07K16/00 ,  C07K16/3092 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/32 ,  C12N9/1051 ,  C12N9/88 ,  C12N9/90

摘要： There has been required a fused protein composition of the Fc domain of an antibody which has an enhanced effector function and is useful as a drug. Thus it is intended to provide a composition comprising a fused protein molecule of the Fc domain of an antibody which has an N-glycoside-binding complex sugar chain in the Fc domain, wherein the N-glycoside-binding complex sugar chain is a sugar chain having no fucose attached to N-acetylglucosamine at the reducing end of the sugar chain; a transformant producing this fused protein composition; a process for producing the fused protein composition; and a drug containing the fused protein composition.

公开(公告)号：EP1333032A4

公开(公告)日：2005-03-16

申请号：EP01974669

申请日：2001-10-03

申请人： KYOWA HAKKO KOGYO KK

发明人： SHINKAWA TOYOHIDE ,  UCHIDA KAZUHISA ,  YAMASAKI MOTOO ,  HOSAKA EMI ,  SHITARA KENYA

IPC分类号： C07K16/06 ,  C07K16/28 ,  C07K1/22 ,  A61K39/395 ,  A61K45/00 ,  G01N33/531

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K16/065 ,  C07K2317/24 ,  C07K2317/732

摘要： An antibody having desired properties which is purified by a method with the use of a substance having an affinity for a sugar chain binding to the antibody; drugs containing the antibody purified by the above method as the active ingredient; and a method of diagnosing or preventing various diseases by using a substance having an affinity for a sugar chain binding to the antibody.

公开(公告)号：EP1266663A4

公开(公告)日：2003-07-23

申请号：EP01904470

申请日：2001-02-15

申请人： KYOWA HAKKO KOGYO KK

发明人： HOSAKA EMI ,  NAKAMURA KAZUYASU ,  KOIKE MASAMICHI ,  SHITARA KENYA ,  HANAI NOBUO

IPC分类号： A61P11/06 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/73 ,  C07K2317/732

摘要： An apoptosis inducer and a remedy for eosinophilic diseases containing as the active ingredient an antibody which reacts specifically with eosinophils and induces the apoptosis of eosinophils; and a method of inducing eosinophil-specific apoptosis and a method of specifically reducing or eliminating eosinophils in peripheral blood or a tissue infiltrated with eosinophils with the use of the above antibody.