公开(公告)号：EP1366759A4

公开(公告)日：2006-04-19

申请号：EP02703917

申请日：2002-03-05

申请人： KYOWA HAKKO KOGYO KK ,  TAISHO PHARMA CO LTD

发明人： OHTA MOTOHIRO ,  KUBOYAMA MUNEKO ,  YOSHIMOTO HIROKAZU ,  WATANABE YASUSHI ,  MORIMOTO KIYOSHI ,  KOSUGI MAKOTO

IPC分类号： A61K9/20 ,  A61K9/00 ,  A61K47/26 ,  A61K47/32 ,  A61K31/164 ,  A61K45/00 ,  A61K47/10

CPC分类号： A61K47/32 ,  A61K9/0056 ,  A61K47/26

摘要： Tablets quickly disintegrating in the oral cavity without resort of water and sustaining a practically usable tablet hardness which contain: (a) a pharmacologically active ingredient having a solubility in water of at least about 1 mg/ml; (b) crystals or fine particles of D-mannitol having an average particle diameter of primary particles of about 30 ñm or more and a specific surface area of about 0.4 m /g or less; and (c) crospovidone.

公开(公告)号：EP1043009A4

公开(公告)日：2003-04-02

申请号：EP98957166

申请日：1998-12-03

申请人： KYOWA HAKKO KOGYO KK

发明人： HAYAKAWA EIJI ,  OHTA MOTOHIRO ,  MORIMOTO HIROYUKI ,  MORIMOTO KIYOSHI ,  WATANABE YASUSHI ,  ITO KUNIO ,  TOKUNO SANJI

IPC分类号： A61J3/10 ,  B30B11/00 ,  B30B11/08 ,  B30B15/00

CPC分类号： A61J3/10 ,  B30B11/08 ,  B30B15/0011 ,  Y10T428/2991

摘要： A process for the production of tablets essentially composed of an active ingredient, a filler and a lubricant (L), which comprises the step of preparing a molding material (m) essentially consisting of the active ingredient, the filler and part (Wc) of the lubricant (L), the step of applying the rest (We) of the lubricant (L) on the surfaces (3s, 4s) of punches (3, 4) and the surface (1s) of a die (1), and the step of tabletting the material (m) by using the punches (3, 4) and die (1) whose surfaces (3s, 4s, 1s) are coated with the lubricant (L).

摘要翻译： 一种生产基本上由活性成分，填料和润滑剂（L）组成的片剂的方法，其包括以下步骤：制备基本上由活性成分，填料和部分（Wc）组成的成型材料（m） 润滑剂（L），在冲头（3,4）和模具（1）的表面（1s）的表面（3s，4s）上施加润滑剂（L）的其余部分（We）的步骤，以及 通过使用表面3s，4s，1s）的冲头（3,4）和模具（1）涂覆润滑剂（L）来对材料（m）进行压片的步骤。

公开(公告)号：EP1279487A4

公开(公告)日：2005-07-13

申请号：EP01919900

申请日：2001-04-12

申请人： KYOWA HAKKO KOGYO KK

发明人： WATANABE YASUSHI ,  MORIMOTO KIYOSHI ,  IWASE YUJI ,  HIRUTA SATORU

IPC分类号： B05B1/04 ,  B30B11/08 ,  B30B15/00 ,  A61J3/06

CPC分类号： B30B11/08 ,  B30B15/0011 ,  Y10T83/9423

摘要： A coating device for powder material, capable of applying powder material onto the lower surfaces of a plurality of upper mallets, upper surfaces of a plurality of lower mallets and inner peripheral wall surfaces of a plurality of mortars in a tablet making machine. Air-mixed powder material is sprayed onto the material-contacting surfaces of lower mallets from the lower-mallet powder-material spraying ports of a lower-mallet powder-material spray unit to apply powder material to the material-contacting surfaces of the lower mallets, and air-mixed powder material sprayed from the lower-mallet powder-material spraying ports is sprayed, along the rotation paths of a plurality of upper mallets of an upper-mallet powder-material spray unit, from upper-mallet powder-material spraying ports provided to extend longer than the lower-mallet powder-material spraying ports to spray powder material onto the material-contacting surfaces of the upper mallets, that are hard to be coated with powder material due to a gravity problem, while the upper mallets move from the proximal ends to the distal ends of the upper-mallet powder-material spraying ports.

公开(公告)号：EP1161940A4

公开(公告)日：2002-09-04

申请号：EP00903982

申请日：2000-02-16

申请人： KYOWA HAKKO KOGYO KK

发明人： WATANABE YASUSHI ,  MORIMOTO KIYOSHI ,  IWASE YUJI ,  HIRUTA SATORU

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K47/26

CPC分类号： A61K9/2095 ,  A61K9/0056 ,  A61K9/2018

摘要： Tablets obtained by binding a powdery mixture (5a, 5) containing at least the principal agent (2), a highly wettable saccharide (3) and a disintegrating agent (4) by using a binder (6, 6c) containing a highly wettable saccharide to give granules (1a, 1b, 1c), and then compression-molding these granules (1a, 1b, 1c). A process for producing tablets which comprises the step of mixing a powdery mixture (5a, 5), which has been prepared by homogeneously mixing at least the principal agent (2), highly wettable saccharide grains (3) and disintegrating agent grains (4), with air to give a fluidized bed; the step of producing granules (1a, 1b, 1c) containing the principal agent by spraying an aqueous solution of a binder (6, 6c) and a highly wettable saccharide (3) dissolved therein onto the above-mentioned fluidized bed of the powdery mixture (5, 5a) followed by spraying; and the step of compression-molding these granules (1a, 1b, 1c) containing the principal agent (2).

公开(公告)号：EP0914818A4

公开(公告)日：2001-03-14

申请号：EP97927372

申请日：1997-06-12

申请人： KYOWA HAKKO KOGYO KK

发明人： OHTA MOTOHIRO ,  HAYAKAWA EIJI ,  ITO KUNIO ,  TOKUNO SANJI ,  MORIMOTO KIYOSHI ,  WATANABE YASUSHI

IPC分类号： A61J3/10 ,  A61K9/00 ,  A61K9/20 ,  A61K47/10 ,  A61K47/26

CPC分类号： A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： A tablet comprising sugar alcohol or saccaride having an average particle diameter of not more than 30 mu m, an active ingredient, and a disintegrant. It is an intraorally rapidly disintegrable tablet which does not require a special pharmaceutical manufacturing technology and can be simply and easily produced by a normal equipment.

公开(公告)号：EP1070497A4

公开(公告)日：2009-01-21

申请号：EP99913634

申请日：1999-04-09

申请人： KYOWA HAKKO KOGYO KK

发明人： MORIMOTO HIROYUKI ,  HAYAKAWA EIJI ,  OHTA MOTOHIRO ,  MORIMOTO KIYOSHI ,  WATANABE YASUSHI ,  GOTO TOMOHIKO

IPC分类号： A61J3/00 ,  A61J3/10 ,  B30B15/00

CPC分类号： B30B15/0011 ,  A61J3/005 ,  A61J3/10

摘要： A tablet manufacturing method comprising a step of providing molding materials including effective ingredients, a step of applying a lubricant to the surfaces of a mortar and a mallow housed in a spray room in advance by generating air pulsation wave and spraying the lubricant within the room and a step of compressing the molding materials using the lubricant-coated mortar and mallow.

公开(公告)号：EP1197265A4

公开(公告)日：2006-11-15

申请号：EP00944259

申请日：2000-07-05

申请人： KYOWA HAKKO KOGYO KK

发明人： WATANABE YASUSHI ,  HAYAKAWA KIMIAKI ,  MORIMOTO KIYOSHI

IPC分类号： A61K9/28 ,  B05B7/14 ,  B30B15/00

CPC分类号： B30B15/0011 ,  B05B7/1404 ,  B05B7/144

摘要： A powder material spraying device, wherein a fixed quantity spraying device (3) is fitted to a material delivery port (2a) of a powder material storage hopper (2) through a material dispensing valve (34), a cover body (2c) is fitted to a material charge port (2b) of the powder material storage hopper (2); the fixed quantity spraying device (3) comprising a tubular body (31) connected to the material delivery port (2a) of the powder material storage hopper (2), an elastic film (32) installed so as to form a bottom surface of the tubular body (31) and having a through-hole (32a), and a dispersion chamber (33) connected to the bottom part of the tubular body (31) through the elastic film (32), the dispersion chamber (33) comprising a pulsating aerial vibration wave feeding port (33e1) feeding positive pressure pulsating aerial vibration wave into the dispersion chamber (33) and an exhaust port (33e2), a bypass tube (35) being connected between the tubular body (31) and the dispersion chamber (33) to spray powder material from a tip (e2) of a conduit (T2) connected to the exhaust port (33e2) of the dispersion chamber (33).

公开(公告)号：EP1120111A4

公开(公告)日：2003-06-18

申请号：EP99969950

申请日：1999-10-05

申请人： KYOWA HAKKO KOGYO KK

发明人： WATANABE YASUSHI ,  MORIMOTO KIYOSHI ,  IWASE YUJI

IPC分类号： A61K9/28 ,  B30B15/00 ,  A61K9/20 ,  A61K31/375 ,  A61K31/616

CPC分类号： B30B15/0011 ,  A61K9/282

摘要： Tablets containing a drug affected in contact with a lubricating agent, wherein the tablets contain no lubricating agent in it, the inner structure of the tablets comprises a compressed mixture of the drug with a filler, and a lubricating agent is located on the tablet surface. A process for producing tablets which involves the step of mixing a drug affected in contact with a lubricating agent with a filler to give a mixture; the step of mixing a lubricating agent powder and dispersing with air-pulsating wave under positive pressure; the step of spraying the lubricating agent powder, which has been dispersed by the above air-pulsating wave under positive pressure, onto the bottom face of the upper pestle, the top face of the lower pestle and the side face of the mortar of a tabletting machine so as to coat the bottom face of the upper pestle, the top face of the lower pestle and the side face of the mortar with the powder; and the step of compression-molding the above mixture by using the pestles and mortar coated at each surface with the lubricating agent.

公开(公告)号：EP1350504A4

公开(公告)日：2005-12-07

申请号：EP01999252

申请日：2001-12-06

申请人： KYOWA HAKKO KOGYO KK

发明人： WATANABE YASUSHI ,  HAYAKAWA KIMIAKI ,  HIROTA EIICHIRO ,  MORIMOTO KIYOSHI

IPC分类号： A61J3/10 ,  B01J2/00 ,  B01J2/16 ,  B01J2/22 ,  B30B15/00 ,  A61J3/06

CPC分类号： C04B41/009 ,  A61J3/10 ,  B01J2/00 ,  B01J2/16 ,  B01J2/22 ,  B30B15/0011 ,  C04B41/5022 ,  C04B2111/00836 ,  C04B41/4523 ,  C04B35/10 ,  C04B35/119 ,  C04B35/443 ,  C04B35/447

摘要： An apparatus for producing tablets which has a gas generating device (G), a lubricant powder puffing device (51) puffing a lubricant powder into the gas from the gas generating device (G) in an amount depending on that of the gas, followed by mixing and dispersing, a lubricant applying device (91) spraying the lubricant powder puffed from the lubricant powder puffing device (51) and mixed with and dispersed in the gas generated from the gas generating device (G) onto the surface contacting with a material of each of a mortar, an upper pounder and an under pounder, and an oxygen concentration measuring device (131a) measuring an oxygen concentration of the gas present in the vicinity of the lubricant applying device (91), wherein the amount of the gas to be supplied into the lubricant applying device is controlled based on the oxygen concentration measured by the oxygen concentration measuring device (131a).

公开(公告)号：EP1260220A4

公开(公告)日：2004-09-08

申请号：EP01901372

申请日：2001-01-17

申请人： KYOWA HAKKO KOGYO KK

发明人： WATANABE YASUSHI ,  OHTA MOTOHIRO ,  MORIMOTO KIYOSHI

IPC分类号： A61K8/02 ,  A61K9/46 ,  A61K47/02 ,  A61K47/12 ,  A61Q11/00 ,  A61Q19/10 ,  B30B11/00 ,  B30B11/08 ,  C11D3/00 ,  C11D3/10 ,  C11D3/12 ,  C11D3/20 ,  C11D17/00 ,  A61K7/50 ,  A61K9/00 ,  C01B31/20

CPC分类号： A61K8/02 ,  A61K8/0216 ,  A61K9/0007 ,  A61K2800/222 ,  A61Q11/00 ,  A61Q19/10 ,  B30B15/0011 ,  C11D3/0052 ,  C11D3/10 ,  C11D3/1233 ,  C11D3/2075 ,  C11D17/0073

摘要： Tablets which have been formed by compression-molding a mixture comprising granules of a main ingredient, granules of a carbonic acid salt, and granules of an organic acid by means of a pestle and a mortar, and the surface of which has, transferred and adherent thereto, particles of a lubricant lustering powder which was applied to the pestle and mortar for the compression molding.