公开(公告)号：EP1366759A4

公开(公告)日：2006-04-19

申请号：EP02703917

申请日：2002-03-05

申请人： KYOWA HAKKO KOGYO KK ,  TAISHO PHARMA CO LTD

发明人： OHTA MOTOHIRO ,  KUBOYAMA MUNEKO ,  YOSHIMOTO HIROKAZU ,  WATANABE YASUSHI ,  MORIMOTO KIYOSHI ,  KOSUGI MAKOTO

IPC分类号： A61K9/20 ,  A61K9/00 ,  A61K47/26 ,  A61K47/32 ,  A61K31/164 ,  A61K45/00 ,  A61K47/10

CPC分类号： A61K47/32 ,  A61K9/0056 ,  A61K47/26

摘要： Tablets quickly disintegrating in the oral cavity without resort of water and sustaining a practically usable tablet hardness which contain: (a) a pharmacologically active ingredient having a solubility in water of at least about 1 mg/ml; (b) crystals or fine particles of D-mannitol having an average particle diameter of primary particles of about 30 ñm or more and a specific surface area of about 0.4 m /g or less; and (c) crospovidone.

公开(公告)号：EP1260220A4

公开(公告)日：2004-09-08

申请号：EP01901372

申请日：2001-01-17

申请人： KYOWA HAKKO KOGYO KK

发明人： WATANABE YASUSHI ,  OHTA MOTOHIRO ,  MORIMOTO KIYOSHI

IPC分类号： A61K8/02 ,  A61K9/46 ,  A61K47/02 ,  A61K47/12 ,  A61Q11/00 ,  A61Q19/10 ,  B30B11/00 ,  B30B11/08 ,  C11D3/00 ,  C11D3/10 ,  C11D3/12 ,  C11D3/20 ,  C11D17/00 ,  A61K7/50 ,  A61K9/00 ,  C01B31/20

CPC分类号： A61K8/02 ,  A61K8/0216 ,  A61K9/0007 ,  A61K2800/222 ,  A61Q11/00 ,  A61Q19/10 ,  B30B15/0011 ,  C11D3/0052 ,  C11D3/10 ,  C11D3/1233 ,  C11D3/2075 ,  C11D17/0073

摘要： Tablets which have been formed by compression-molding a mixture comprising granules of a main ingredient, granules of a carbonic acid salt, and granules of an organic acid by means of a pestle and a mortar, and the surface of which has, transferred and adherent thereto, particles of a lubricant lustering powder which was applied to the pestle and mortar for the compression molding.

公开(公告)号：EP1070497A4

公开(公告)日：2009-01-21

申请号：EP99913634

申请日：1999-04-09

申请人： KYOWA HAKKO KOGYO KK

发明人： MORIMOTO HIROYUKI ,  HAYAKAWA EIJI ,  OHTA MOTOHIRO ,  MORIMOTO KIYOSHI ,  WATANABE YASUSHI ,  GOTO TOMOHIKO

IPC分类号： A61J3/00 ,  A61J3/10 ,  B30B15/00

CPC分类号： B30B15/0011 ,  A61J3/005 ,  A61J3/10

摘要： A tablet manufacturing method comprising a step of providing molding materials including effective ingredients, a step of applying a lubricant to the surfaces of a mortar and a mallow housed in a spray room in advance by generating air pulsation wave and spraying the lubricant within the room and a step of compressing the molding materials using the lubricant-coated mortar and mallow.

公开(公告)号：EP0914818A4

公开(公告)日：2001-03-14

申请号：EP97927372

申请日：1997-06-12

申请人： KYOWA HAKKO KOGYO KK

发明人： OHTA MOTOHIRO ,  HAYAKAWA EIJI ,  ITO KUNIO ,  TOKUNO SANJI ,  MORIMOTO KIYOSHI ,  WATANABE YASUSHI

IPC分类号： A61J3/10 ,  A61K9/00 ,  A61K9/20 ,  A61K47/10 ,  A61K47/26

CPC分类号： A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

摘要： A tablet comprising sugar alcohol or saccaride having an average particle diameter of not more than 30 mu m, an active ingredient, and a disintegrant. It is an intraorally rapidly disintegrable tablet which does not require a special pharmaceutical manufacturing technology and can be simply and easily produced by a normal equipment.

公开(公告)号：EP1604659A4

公开(公告)日：2006-05-31

申请号：EP04717765

申请日：2004-03-05

申请人： KYOWA HAKKO KOGYO KK

发明人： OHTA MOTOHIRO ,  MORIMOTO KIYOSHI ,  KUBOYAMA MUNEKO ,  YOSHIMOTO HIROKAZU ,  KAWABE HIDEO

IPC分类号： A23L1/29 ,  A23L1/305 ,  A61K9/16 ,  A61K9/68 ,  A61K31/198 ,  A61K31/401 ,  A61P3/02 ,  A61K9/20 ,  A61K47/30 ,  A61K47/38

CPC分类号： A61K31/401 ,  A23L33/175 ,  A23L33/30 ,  A61K9/0058 ,  A61K9/1617 ,  A61K31/198

摘要： A tablet characterized in that a water-absorbing amino acid and an ethanol soluble coating agent with low solubility in water are contained. This tablet is useful as amino acid preparations for sports, dieting and drugs, and useful as dietary supplements, drugs, etc. for nutritional support of amino acids, which are effective in the health maintenance of human body, and for enhancing the bioactivity of human organism.

公开(公告)号：EP1043009A4

公开(公告)日：2003-04-02

申请号：EP98957166

申请日：1998-12-03

申请人： KYOWA HAKKO KOGYO KK

发明人： HAYAKAWA EIJI ,  OHTA MOTOHIRO ,  MORIMOTO HIROYUKI ,  MORIMOTO KIYOSHI ,  WATANABE YASUSHI ,  ITO KUNIO ,  TOKUNO SANJI

IPC分类号： A61J3/10 ,  B30B11/00 ,  B30B11/08 ,  B30B15/00

CPC分类号： A61J3/10 ,  B30B11/08 ,  B30B15/0011 ,  Y10T428/2991

摘要： A process for the production of tablets essentially composed of an active ingredient, a filler and a lubricant (L), which comprises the step of preparing a molding material (m) essentially consisting of the active ingredient, the filler and part (Wc) of the lubricant (L), the step of applying the rest (We) of the lubricant (L) on the surfaces (3s, 4s) of punches (3, 4) and the surface (1s) of a die (1), and the step of tabletting the material (m) by using the punches (3, 4) and die (1) whose surfaces (3s, 4s, 1s) are coated with the lubricant (L).

摘要翻译： 一种生产基本上由活性成分，填料和润滑剂（L）组成的片剂的方法，其包括以下步骤：制备基本上由活性成分，填料和部分（Wc）组成的成型材料（m） 润滑剂（L），在冲头（3,4）和模具（1）的表面（1s）的表面（3s，4s）上施加润滑剂（L）的其余部分（We）的步骤，以及 通过使用表面3s，4s，1s）的冲头（3,4）和模具（1）涂覆润滑剂（L）来对材料（m）进行压片的步骤。