公开(公告)号：EP4331681A3

公开(公告)日：2024-05-22

申请号：EP24150035.4

申请日：2019-03-14

申请人： Kabushiki Kaisha Toshiba

发明人： ISHIHARA, Mitsuko ,  AKAHOSHI, Eiichi ,  NAITO, Katsuyuki ,  NOZAKI, Emi ,  SARUWATARI, Saeko

IPC分类号： A61P43/00

CPC分类号： A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K45/00 ,  A61K47/24 ,  A61K47/18 ,  A61K47/22 ,  A61K48/00 ,  A61P43/00 ,  C07C229/24 ,  C07D233/02 ,  C07D243/08 ,  C07D251/04 ,  C07D295/15 ,  C07D295/13 ,  C07D211/14 ,  C07D241/04 ,  A61K9/1272

摘要： The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,
where a compound represented by the formula (1):

         Q-CHR2     (1)

wherein
Q is represented by the following formula (1-Q):

         RQ12N-(CRQ22)q1-NRQ1-(CRQ22)q2-*     (1-Q)

wherein
each RQ1 is independently an alkyl,
each RQ2 is independently hydrogen or an alkyl,
any two of RQ1s and RQ2s may link together to form a nitrogen-containing alicyclic ring,
q1 is an integer of 1 to 4,
q2 is an integer of 0 to 4, and
the mark * indicates the position bonding to -CHR2; and
each R is independently an aliphatic group of C12 to C24;
wherein said R is represented by the following formula (1-R):

         -LR1-C(=O)-O-LR2     (1-R)

where
LR1 is alkylene and
LR2 is represented by the following formula (1-R2):

         -CH2-CH=CH-(CH2)r2-H     (1-R2)

where r2 is an integer of 1 to 10.

公开(公告)号：EP4331681A2

公开(公告)日：2024-03-06

申请号：EP24150035.4

申请日：2019-03-14

申请人： Kabushiki Kaisha Toshiba

发明人： ISHIHARA, Mitsuko ,  AKAHOSHI, Eiichi ,  NAITO, Katsuyuki ,  NOZAKI, Emi ,  SARUWATARI, Saeko

IPC分类号： A61P43/00

摘要： The present embodiment provides a method for delivering activators to cells, wherein said activator containing lipid particles are brought into contact with the cells,
where a compound represented by the formula (1):

         Q-CHR 2      (1)

wherein
Q is represented by the following formula (1-Q):

         R Q1 2 N-(CR Q2 2 ) q1 -NR Q1 -(CR Q2 2 ) q2 -*     (1-Q)

wherein
each R Q1 is independently an alkyl,
each R Q2 is independently hydrogen or an alkyl,
any two of R Q1 s and R Q2 s may link together to form a nitrogen-containing alicyclic ring,
q1 is an integer of 1 to 4,
q2 is an integer of 0 to 4, and
the mark * indicates the position bonding to -CHR 2 ; and
each R is independently an aliphatic group of C 12 to C 24;
wherein said R is represented by the following formula (1-R):

         -L R1 -C(=O)-O-L R2      (1-R)

where
L R1 is alkylene and
L R2 is represented by the following formula (1-R2):

         -CH 2 -CH=CH-(CH 2 ) r2 -H     (1-R2)

where r2 is an integer of 1 to 10.