公开(公告)号：EP2787079A1

公开(公告)日：2014-10-08

申请号：EP12852729.8

申请日：2012-11-29

申请人： Kagoshima University ,  Otsuka Chemical Co., Ltd.

发明人： ITO, Yuji ,  ITO, Osamu ,  OOZONO, Shinji ,  ISHITOBI, Hiroyuki

IPC分类号： C12N15/09 ,  C07K1/22 ,  C07K7/08 ,  C07K16/00 ,  C07K17/00 ,  C07K19/00 ,  G01N33/53

CPC分类号： C07K7/08 ,  C07K1/22 ,  C07K16/065 ,  C07K17/00 ,  C07K2319/00 ,  G01N33/6854

摘要： This invention provides a peptide that comprises an amino acid sequence consisting of 14 to 18 amino acid residues represented by Formula (I) and is capable of binding to human IgA:

        H-(X 1 )-V-C-L-S-Y-R-(X 2 )-(X 3 )-G-(X 4 )-P-(X 5 )-C-(X 6 )-(X 7 )-(X 8 )     (I) (SEQ ID NO: 1)

wherein each X is independently selected from among the following: X 1 represents a Gln residue or a Met residue; X 2 and X 3 each independently represent an arbitrary amino acid residue other than Cys or either or both thereof are deleted; X 4 represents an Arg residue or a Gln residue; X 5 represents a Val residue or a Thr residue; X 6 represents a Phe residue or a Tyr residue; X 7 represents a Ser residue or is null; and X 8 represents a Leu residue, a Thr residue, or is null, provided that, when X 1 represents a Met residue, X 7 represents a Ser residue or is null, and X 8 is null. The invention also provides a method for purifying or analyzing human IgA using such peptide.

摘要翻译： 本发明提供一种肽，其包含由式（I）表示的14至18个氨基酸残基并能够结合人IgA的氨基酸序列：€ƒ€€ƒ€ƒ€ƒ€ƒH - （X 1）-VCLSYR-（X 2） - （X 3）-G-（X 4）-P-（X 5）-C-（X 6） - （X 7） - （X 8） （I）（I）（SEQ ID NO：1），其中每个X独立地选自以下各项：X 1表示Gln残基或Met残基; X 2和X 3各自独立地表示除Cys之外的任意氨基酸残基，或者两者之一或两者都被缺失; X 4表示Arg残基或Gln残基; X 5表示Val残基或Thr残基; X 6表示Phe残基或Tyr残基; X 7表示Ser残基或无效; 并且X 8表示Leu残基，Thr残基或为空，条件是当X 1表示Met残基时，X 7表示Ser残基或为空，X 8为空。 本发明还提供了使用这种肽纯化或分析人IgA的方法。

公开(公告)号：EP3617190A1

公开(公告)日：2020-03-04

申请号：EP18792072.3

申请日：2018-04-23

申请人： Kyoto University ,  Otsuka Chemical Co., Ltd.

发明人： YAMAGO, Shigeru ,  ITO, Osamu

IPC分类号： C07C395/00 ,  C08F4/00 ,  C08F20/00 ,  C08F26/10

摘要： Provided is an organic tellurium compound having a versatility that, when used as a living radical polymerization initiator, it is applicable to polymerization of a vinyl monomer in an aqueous vehicle without using any surfactant or dispersant. An organic tellurium compound represented by a general formula (1),

where in the general formula (1) R 1 and R 2 each independently represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, A represents an alkali metal atom or an alkaline earth metal atom, x = 1 when A is monovalent, x = 1/2 when A is divalent, and R 3 is represented by a general formula (2),

where in the general formula (2) R 4 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, R 5 and R 6 each independently represent an alkylene group having 2 to 8 carbon atoms, and a represents an integer from 0 to 10.