公开(公告)号：EP2125807A2

公开(公告)日：2009-12-02

申请号：EP07855374.0

申请日：2007-12-14

申请人： Katholieke Universiteit Leuven ,  Université D'auvergne Clermont 1 ,  Universite Francois Rabelais de Tours

发明人： NEYTS, Johan ,  PAESHUYSE, Jan ,  CHAVIGNON, Olivier ,  CHEZAL, Jean-Michel ,  GAUMET, Vincent ,  GUEIFFIER, Alain ,  TEULADE, Jean-Claude

IPC分类号： C07D471/04 ,  A61K31/4355

CPC分类号： C07D471/04

摘要： The present invention relates to a series of novel imidazo[1,2-α]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Triaza-αy-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2- α]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).

公开(公告)号：EP2125807B1

公开(公告)日：2011-08-03

申请号：EP07855374.0

申请日：2007-12-14

申请人： Katholieke Universiteit Leuven ,  Université D'Auvergne Clermont 1 ,  Université Francois Rabelais de Tours

发明人： NEYTS, Johan ,  PAESHUYSE, Jan ,  CHAVIGNON, Olivier ,  CHEZAL, Jean-Michel ,  GAUMET, Vincent ,  GUEIFFIER, Alain ,  TEULADE, Jean-Claude

IPC分类号： C07D471/04 ,  A61K31/4355

CPC分类号： C07D471/04

摘要： The present invention relates to a series of novel imidazo[1,2-α]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Triaza-αy-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2- α]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).

公开(公告)号：EP2252605A2

公开(公告)日：2010-11-24

申请号：EP09705728.5

申请日：2009-01-28

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Université d'Auvergne Clermont 1 ,  Laboratoires Cyclopharma

发明人： CHEZAL, Jean-Michel ,  DOLLE, Frédéric ,  MADELMONT, Jean-Claude ,  MAISONIAL, Aurélie ,  MIOT-NOIRAULT, Elisabeth ,  MOINS, Nicole ,  PAPON, Janine ,  KUHNAST, Bertand ,  TAVITIAN, Bertrand ,  BOISGARD, Raphaël

IPC分类号： C07D401/12 ,  C07D241/44 ,  C07D215/54 ,  C07D215/48 ,  C07D215/50 ,  A61K31/498 ,  A61K31/47 ,  A61P35/00

CPC分类号： A61K49/0002 ,  C07D213/65 ,  C07D213/76 ,  C07D215/54 ,  C07D241/44 ,  C07D401/12 ,  C07D487/04

摘要： The present invention relates to the compound of formula (I): in which R 1 represents a hydrogen atom, an optionally labelled halogen atom, a radionuclide or a Sn[(C 1 -C 4 )alkyl] 3 group, Ar represents an aryl group or a heteroaryl group, R 9 represents a hydrogen atom, a (C 1 -C 4 )alkyl group or forms together with the group R 1 -Ar a ring fused with the Ar group, A represents a group of formula (²) or (´): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -(CH 2 ) t -€ƒ€ƒ€ƒ€ƒ€ƒ(²) R 3 and R 4 independently represent a hydrogen atom, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkenyl group or a group of formula (y): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -Y-Z-W-R 11 €ƒ€ƒ€ƒ€ƒ€ƒ(³) wherein R 11 represents an optionally labelled halogen atom, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen atom, a radionuclide, a -NO 2 group, a -NR 5 R 6 group, a -N + R 5 R 6 R 7 X - group, or a -OSO 2 R 12 group, and their addition salts with pharmaceutically acceptable acids. The present invention also relates to pharmaceutical compositions comprising them and to their use in diagnosis, in particular with SPECT, PET and in therapy.

摘要翻译： 本发明涉及式（I）化合物：其中R 1表示氢原子，任选标记的卤素原子，放射性核素或Sn [（C 1 -C 4）烷基] 3基团，Ar表示芳基 基团或杂芳基，R 9表示氢原子，（C 1 -C 4）烷基或与Ar基团稠合的基团R 1 -Ar a形成，A表示式（²）的基团， 或（'）：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ - （CH 2）t - €ƒ€ƒ€ƒ（²）R 3和R 4独立地表示氢 原子，（C 1 -C 6）烷基，（C 1 -C 6）烯基或式（y）的基团：ƒ€ƒ€ƒ€ƒ€ƒ€ƒ-YZWR 11ƒ€ƒ€ƒ€ƒ（³）其中R 11表示任选标记的卤素原子，任选被任意标记的卤素原子取代的放射性核素，芳基或杂芳基，放射性核素，-NO 2基， -NR 5 R 6基团，-N + R 5 R 6 R 7 X基团或-OSO 2 R 12基团，以及它们的 与药学上可接受的酸的盐。 本发明还涉及包含它们的药物组合物及其在诊断中的用途，特别是在SPECT，PET和治疗中的用途。