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1.发明授权IMIDAZO[1,2-A]PYRROLO[3,2-C]PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS 有权作为抑制剂瘟病毒SUITABLE咪唑并[1,2-a]吡咯并[3,2-C]吡啶
公开(公告)号：EP2125807B1
公开(公告)日：2011-08-03
申请号：EP07855374.0
申请日：2007-12-14
申请人： Katholieke Universiteit Leuven , Université D'Auvergne Clermont 1 , Université Francois Rabelais de Tours
发明人： NEYTS, Johan , PAESHUYSE, Jan , CHAVIGNON, Olivier , CHEZAL, Jean-Michel , GAUMET, Vincent , GUEIFFIER, Alain , TEULADE, Jean-Claude
IPC分类号： C07D471/04 , A61K31/4355
CPC分类号： C07D471/04
摘要： The present invention relates to a series of novel imidazo[1,2-α]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Triaza-αy-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2- α]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).
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2.发明公开IMIDAZO[1,2-A]PYRROLO[3,2-C]PYRIDINE COMPOUNDS USEFUL AS PESTIVIRUS INHIBITORS 有权作为抑制剂瘟病毒SUITABLE咪唑并[1,2-a]吡咯并[3,2-C]吡啶
公开(公告)号：EP2125807A2
公开(公告)日：2009-12-02
申请号：EP07855374.0
申请日：2007-12-14
申请人： Katholieke Universiteit Leuven , Université D'auvergne Clermont 1 , Universite Francois Rabelais de Tours
发明人： NEYTS, Johan , PAESHUYSE, Jan , CHAVIGNON, Olivier , CHEZAL, Jean-Michel , GAUMET, Vincent , GUEIFFIER, Alain , TEULADE, Jean-Claude
IPC分类号： C07D471/04 , A61K31/4355
CPC分类号： C07D471/04
摘要： The present invention relates to a series of novel imidazo[1,2-α]pyrrolo[3,2-c]pyridines (or also named 6H-1,3a,6-Triaza-αy-indacenes) and derivatives thereof, according to formula: (I); The present invention also relates to processes for the preparation of imidazo[1,2- α]pyrrolo[3,2-c]pyridines, their use as. a, medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Bovine Viral Diarrhea virus (BVDV).
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公开(公告)号：EP4110380A1
公开(公告)日：2023-01-04
申请号：EP21706473.2
申请日：2021-03-01
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公开(公告)号：EP3882244A1
公开(公告)日：2021-09-22
申请号：EP21152125.7
申请日：2013-12-16
发明人： JUNG, Young Sik , HAN, Soo Bong , LEE, Chong-Kyo , KIM, Hae Soo , NEYTS, Johan , THIBAUT, Hendrik Jan , MALPANI, Yashwardhan Radhamohan , SHIN, Jin Soo
IPC分类号： C07D405/12 , C07D409/12 , A61K31/4025 , A61P31/12
摘要： The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.
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公开(公告)号：EP2978753A1
公开(公告)日：2016-02-03
申请号：EP14718338.8
申请日：2014-03-25
发明人： BARDIOT, Dorothée , CARLENS, Gunter , DALLMEIER, Kai , KAPTEIN, Suzanne , KOUKNI, Mohamed , MARCHAND, Arnaud , NEYTS, Johan , SMETS, Wim
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D223/04 , C07D231/12 , C07D333/22 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/06
摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.
摘要翻译： 本发明涉及一系列新化合物，通过使用新化合物预防或治疗动物中的病毒感染的方法和用作药物的所述新化合物，更优选用作治疗或预防病毒感染的药物， 特别是RNA病毒的感染，更特别是属于黄病毒科的病毒感染，更特别是登革热病毒的感染。 本发明还涉及新化合物的药物组合物或组合制剂，用作药物的组合物或制剂，更优选用于预防或治疗病毒感染。 本发明还涉及化合物的制备方法。
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7.发明公开INDANONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES 审中-公开茚满酮衍生物，药学上可接受的盐或其旋光异构体，PROCESS FOR THEIR和药物组合物因此可用作ACTIVE用于预防或治疗病毒病
公开(公告)号：EP2722042A2
公开(公告)日：2014-04-23
申请号：EP12800577.4
申请日：2012-06-18
申请人： Korea Research Institute of Chemical Technology , Katholieke Universiteit Leuven, K.U. Leuven R&D
发明人： JUNG, Young Sik , LEE, Chong Kgo , KIM, Hae Soo , JEONG, Hee Chun , KIM, Pil Ho , HAN, Soo Bong , NEYTS, Johan , THIBAUT, Hendrik Jan , SHIN, Jin Soo
IPC分类号： A61K31/34 , A61K31/343 , A61K31/12 , A61P31/12
CPC分类号： C07D307/93 , C07C233/32 , C07D209/94 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07F9/65517
摘要： The present invention relates to a novel indanone derivative, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient for preventing or treating viral diseases. The indanone derivatives according to the present invention not only have low cyto-toxicity, but can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.
摘要翻译： 本发明涉及一种新颖茚满酮衍生物，药学上可接受的盐或旋光异构体，对相同的制备方法，以及含有相同的用于预防或治疗病毒疾病的活性成分的药物组合物。 茚满酮衍生物gemäß到本发明不仅具有低CYTO-毒性，但由此可以证明可用作用于预防或治疗病毒性疾病的药物组合物：如：; 脊髓灰质炎病毒麻痹，急性出血性结膜炎，病毒性脑膜炎，手足口病，水疱病，A型肝炎，肌炎，心肌炎，胰腺炎，病毒性糖尿病，流行性肌痛，脑炎，流感，疱疹性咽峡，手足口病 ，哮喘，慢性阻塞性肺疾病，肺炎，鼻窦炎，中耳炎等，因为对小核糖核酸病毒优异的抗病毒活性：如柯萨奇病毒，肠道病毒，埃可病毒，脊髓灰质炎病毒，鼻病毒等，已经以实例阐述。
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公开(公告)号：EP4360710A2
公开(公告)日：2024-05-01
申请号：EP23218086.9
申请日：2012-06-18
发明人： JUNG, Young Sik , LEE, Chong Kgo , CHOI, Ihl Young , KIM, Hae Soo , KIM, Pil Ho , HAN, Soo Bong , NEYTS, Johan , THIBAUT, Hendrik Jan
IPC分类号： A61P31/00
CPC分类号： C07C271/24 , C07C271/44 , C07C271/64 , C07C275/26 , C07C275/64 , C07C205/45 , C07C323/22 , C07C225/20 , C07C225/22 , C07C233/41 , C07C233/61 , C07C233/76 , C07C247/14 , C07C69/16 , C07C69/18 , C07C69/28 , C07C69/54 , C07C69/618 , C07C69/63 , C07C69/738 , C07C69/78 , C07C49/747 , C07C49/753 , C07D215/20 , C07D213/65 , C07C2601/0220170501 , C07C2602/0820170501 , C07D221/04 , A61P11/02 , A61P17/00 , A61P21/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/16 , A61P3/10 , A61P9/00 , Y02A50/30
摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
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公开(公告)号：EP3846847A1
公开(公告)日：2021-07-14
申请号：EP19766223.2
申请日：2019-09-06
发明人： DALLMEIER, Kai , MISHRA, Niraj , NEYTS, Johan , SANCHEZ, Lorena
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公开(公告)号：EP2989205B1
公开(公告)日：2019-01-02
申请号：EP14724009.7
申请日：2014-04-25
发明人： DALLMEIER, Kai , NEYTS, Johan
IPC分类号： C12N15/69
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