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1.发明授权INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权维生素D VERBINDUNGEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN INDOLAMIDDERIVATE
公开(公告)号：EP2440550B1
公开(公告)日：2017-03-15
申请号：EP10728150.3
申请日：2010-06-11
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Veronica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4045 , A61P25/28
CPC分类号： A61K31/4045 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/635 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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2.发明公开INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权INDOLAMIDDERIVATE和神经退行性疾病的治疗相关的化合物
公开(公告)号：EP2440550A1
公开(公告)日：2012-04-18
申请号：EP10728150.3
申请日：2010-06-11
发明人： GRIFFIOEN, Gerard , VAN DOOREN, Tom , ROJAS DE LA PARRA, Veronica , MARCHAND, Arnaud , ALLASIA, Sara , KILONDA, Amuri , CHALTIN, Patrick
IPC分类号： C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/4045 , A61P25/28
CPC分类号： A61K31/4045 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/635 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.
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3.发明授权PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权苯基和BENZYLTHIAZOLYLPIPERAZINDERIVATE神经退行性疾病的治疗
公开(公告)号：EP2188272B1
公开(公告)日：2016-02-24
申请号：EP08786967.3
申请日：2008-08-06
申请人： reMYND NV
IPC分类号： C07D277/42 , C07D417/06 , C07D417/12 , C07D417/04 , A61K31/496 , A61P25/28
CPC分类号： C07D417/06 , C07D277/42 , C07D417/04 , C07D417/12
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4.发明公开PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权苯基和BENZYLTHIAZOLYLPIPERAZINDERIVATE神经退行性疾病的治疗
公开(公告)号：EP2188272A2
公开(公告)日：2010-05-26
申请号：EP08786967.3
申请日：2008-08-06
申请人： NV Remynd
IPC分类号： C07D277/42 , C07D417/06 , C07D417/12 , C07D417/04 , A61K31/496 , A61P25/28
CPC分类号： C07D417/06 , C07D277/42 , C07D417/04 , C07D417/12
摘要： This invention provides phenyl- and benzyl-thiazolylpiperazine derivatives, and
N -sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.
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