公开(公告)号：EP3741368A1

公开(公告)日：2020-11-25

申请号：EP19741610.0

申请日：2019-01-16

申请人： Keio University ,  Foundation for Biomedical Research and Innovation at Kobe ,  Morishita Jintan Co., Ltd.

发明人： KANAI, Takanori ,  NISHIMURA, Hideo ,  KOYAMA, Tomoyuki ,  ADACHI, Takuhiko ,  HAYAKAWA, Hiroyuki

IPC分类号： A61K31/404 ,  A61K9/52 ,  A61K47/14 ,  A61K47/36 ,  A61K47/42 ,  A61P1/04

摘要： An object of the present invention is to obtain a capsule for treating ulcerative colitis which, when a capsule containing indigo is orally administered, acts more effectively than conventional ones and has less side effects of hepatotoxicity by not easily disintegrating in the stomach and small intestine but only in the large intestine. The present invention relates to a capsule for treating ulcerative colitis which disintegrates locally in the large intestine, comprising a drug-containing content, a protective layer coating the content and a film formed outside the protective layer, which are arranged concentrically, wherein the content is a content in which indigo, which is a drug for treating ulcerative colitis, is dispersed or dissolved, and the film is locally disintegrated in the large intestine.

公开(公告)号：EP3103351A1

公开(公告)日：2016-12-14

申请号：EP15742854.1

申请日：2015-01-30

申请人： Morishita Jintan Co., Ltd. ,  Research Institute of Environment, Agriculture And Fisheries, Osaka Prefecture

发明人： ADACHI, Takuhiko ,  SEYAMA, Tomohiro ,  HIRAYASU, Hirofumi ,  KASAI, Koji ,  FUJITANI, Yasuhiro

IPC分类号： A23K50/00 ,  A23K10/40

CPC分类号： A61K9/0056 ,  A23K20/105 ,  A23K20/174 ,  A23K40/35 ,  A23K50/10 ,  A61J3/07 ,  A61K9/4816 ,  A61K9/4833 ,  A61K9/485 ,  A61K9/4866 ,  A61K9/4875 ,  A61K31/375 ,  A61K31/51 ,  A61K35/747 ,  A61K2035/115

摘要： The present invention provides an orally administered agent for ruminants which reaches lower digestive tract without decomposition in the rumen by avoiding the destruction thereof due to rumination, and is disintegrated and dissolved in vivo.
The present invention provides an orally administered agent for ruminants, of which the specific gravity is 1.17 to 2.00, the maximum particle size and minimum particle size are either within the range of 4 to 10 mm, and the breaking strength of a portion having the minimum particle size under body temperature environment of the ruminants is within the range of 0.5 to 5.0 N. The present invention further provides ruminant feed containing the orally administered agent and a method of orally administering a drug to ruminants.

摘要翻译： 本发明提供一种反刍动物的口服给药剂，其通过避免由于反刍而导致的破坏而在瘤胃中不分解而到达下消化道，并在体内崩解并溶解。 本发明提供了一种反刍动物的口服给药剂，其比重为1.17至2.00，最大粒径和最小粒径均在4至10mm的范围内，并且具有最小值的部分的断裂强度 反刍动物的体温环境下的粒径在0.5〜5.0N的范围内。本发明还提供含有口服制剂的反刍动物饲料和向反刍动物口服药物的方法。