公开(公告)号：EP2495568A1

公开(公告)日：2012-09-05

申请号：EP10826878.0

申请日：2010-10-29

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： Tanigawara, Yusuke ,  Suzuki, Sayo ,  Irie, Hidehiro ,  Nishimuta, Akito ,  Suzuki, Tetsuya ,  Sugimoto, Shinji

IPC分类号： G01N33/68 ,  A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  A61P35/00 ,  A61P43/00 ,  G01N27/62 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/574 ,  A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  G01N2800/52 ,  A61K2300/00

摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker.
The marker for determining sensitivity to an anti-cancer agent is formed of a protein selected from the group consisting of a protein or a fragment thereof which is detected as a peak at m/z of 16,450 to 16,620, a protein or a fragment thereof which is detected as a peak at m/z of 22,080 to 22,310, and a protein or a fragment thereof which is detected as a peak at m/z of 17,100 to 17,270, the peaks being determined by means of a mass spectrometer.

摘要翻译： 为了提供用于确定患者对抗癌剂的敏感性的标记，以及采用该标记的新型癌症治疗手段。 用于测定对抗癌剂的敏感性的标志物由选自下列的蛋白质形成：作为m / z为16,450至16,620的峰检测的蛋白质或其片段，其蛋白质或其片段，其蛋白质或其片段 被检测为m / z为22,080至22,310的峰，以及在17,100至17,270的m / z处被检测为峰的蛋白质或其片段，所述峰通过质谱仪测定。

公开(公告)号：EP2495568B1

公开(公告)日：2018-08-22

申请号：EP10826878.0

申请日：2010-10-29

申请人： Keio University ,  Kabushiki Kaisha Yakult Honsha

发明人： Tanigawara, Yusuke ,  Suzuki, Sayo ,  Irie, Hidehiro ,  Nishimuta, Akito ,  Suzuki, Tetsuya ,  Sugimoto, Shinji

IPC分类号： A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  G01N33/574

CPC分类号： G01N33/574 ,  A61K31/4745 ,  A61K31/513 ,  A61K45/06 ,  G01N2800/52 ,  A61K2300/00

摘要： To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker. The marker for determining sensitivity to an anti-cancer agent is formed of a protein selected from the group consisting of a protein or a fragment thereof which is detected as a peak at m/z of 16,450 to 16,620, a protein or a fragment thereof which is detected as a peak at m/z of 22,080 to 22,310, and a protein or a fragment thereof which is detected as a peak at m/z of 17,100 to 17,270, the peaks being determined by means of a mass spectrometer.