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    ANTI-TUMOR AGENT AND COMPOUNDING AGENT
    4.
    发明公开
    ANTI-TUMOR AGENT AND COMPOUNDING AGENT 审中-公开

    公开(公告)号：EP3973991A1

    公开(公告)日：2022-03-30

    申请号：EP20806566.4

    申请日：2020-05-07

    申请人： Keio University

    发明人： SAYA, Hideyuki ,  NAGANO, Osamu ,  OTSUKI, Yuji

    IPC分类号： A61K45/00 ,  A61K45/06 ,  A61P35/00 ,  A61P43/00 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/02 ,  C12N9/99 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  A61K31/12 ,  A61K31/135 ,  A61K31/137 ,  A61K31/198 ,  A61K31/4453 ,  A61K31/635

    摘要： [Problem] To provide novel anti-tumor agents and combination drugs.
    [Means to solve] To provide an anti-tumor agent containing, as an active ingredient, a glutathione level reducer or a glutathione S-transferase inhibitor, the anti-tumor agent being adapted to be administered simultaneously with an effective amount of a compound (II); an anti-tumor agent including a compound (II) as an active ingredient, the anti-tumor agent being adapted to be administered simultaneously with an effective amount of a glutathione level reducer or a glutathione S-transferase inhibitor; or an anti-tumor agent containing, as active ingredients, a compound (II) and a glutathione level reducer or a glutathione S-transferase inhibitor, where R 5 is a linear or branched C1-6 alkyl group, R 6 is hydrogen or halogen, R 7 is a linear or branched C1-6 alkyl group optionally substituted with a substituent, the substituent being hydroxy or phenyl, and R 8 is hydrogen or halogen.