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公开(公告)号：EP3400941A1
公开(公告)日：2018-11-14
申请号：EP17735999.9
申请日：2017-01-05
发明人： SAYA, Hideyuki , NAGANO, Osamu , TSUCHIHASHI, Kenji , SUINA, Kentaro , NISHIYAMA, Nobuhiro , TAKEMOTO, Hiroyasu , NOMOTO, Takahiro , MATSUI, Makoto , TOMODA, Keishiro , YAMADA, Naoki , NISHIMORI, Tsukasa
IPC分类号： A61K31/4402 , A61K9/08 , A61K31/655 , A61K31/77 , A61K47/34 , A61K47/50 , A61P35/00
CPC分类号： A61K9/08 , A61K31/4402 , A61K31/655 , A61K31/77 , A61K47/34 , A61K47/50
摘要： The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula:
wherein an average value of n is 4 or larger and 1136 or smaller.-
公开(公告)号：EP4368655A1
公开(公告)日：2024-05-15
申请号：EP22837711.5
申请日：2022-07-06
发明人： OGI, Koichi , MICHINISHI, Junya , OHTAKE, Tomoyuki , IIZUKA, Muneaki , NISHIYAMA, Nobuhiro , TAKEMOTO, Hiroyasu , MIURA, Yutaka , NOMOTO, Takahiro , MATSUI, Makoto , SUNG, Yi-Jung , TOYODA, Masahiro , GHASEMIZADEH, Aria
摘要： The present invention provides a highly pure pH-responsive polymer represented by the following formula (I), a production method thereof, and the like:
(in the formula (I), each symbol is as described in the specification).-
3.发明公开
公开(公告)号：EP3501544A1
公开(公告)日：2019-06-26
申请号：EP17843478.3
申请日：2017-08-17
发明人： NISHIYAMA, Nobuhiro , TAKEMOTO, Hiroyasu , NOMOTO, Takahiro , TOMODA, Keishiro , MATSUI, Makoto , YAMADA, Naoki , HONDA, Yuto , ISHII, Hideshi , MORI, Masaki , KONNO, Masamitsu
IPC分类号： A61K47/42 , A61K45/00 , A61K47/32 , A61K47/34 , A61K47/66 , A61K49/00 , A61K49/14 , A61P35/00
摘要： The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.
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公开(公告)号：EP4368657A1
公开(公告)日：2024-05-15
申请号：EP22837710.7
申请日：2022-07-06
发明人： OGI, Koichi , MICHINISHI, Junya , OHTAKE, Tomoyuki , NISHIYAMA, Nobuhiro , TAKEMOTO, Hiroyasu , MIURA, Yutaka , NOMOTO, Takahiro , MATSUI, Makoto , SUNG, Yi-Jung , TOYODA, Masahiro , GHASEMIZADEH, Aria
IPC分类号： C08G69/42 , A61K9/127 , A61K9/16 , A61K31/7088 , A61K38/02 , A61K45/00 , A61K47/24 , A61K47/34 , A61K47/44 , A61P35/00 , A61P43/00 , C07K16/28 , C12N15/113 , C12N15/115
CPC分类号： A61K9/127 , A61K9/16 , A61K31/7088 , A61K38/02 , A61K45/00 , A61K47/24 , A61K47/34 , A61K47/44 , A61P35/00 , A61P43/00 , C07K16/28 , C08G69/42 , C12N15/115 , C12N15/113
摘要： The present invention provides a pH-responsive lipid derivative represented by a structure represented by the following formula (i):
(in the above-mentioned formula, each symbol is as described in the specification), and a pH-responsive transport carrier which is useful as a transport carrier for safely and efficiently performing delivery of low-molecular-weight drugs and the like to tumor tissues.-
公开(公告)号：EP3778705A1
公开(公告)日：2021-02-17
申请号：EP19776262.8
申请日：2019-03-29
发明人： YOSHIOKA, Hiroki , KAMIYA, Masaki , YAMAMOTO, Yuji , HIRAI, Midori , SASAKI, Akiko , NISHIYAMA, Nobuhiro , MATSUI, Makoto , TAKEMOTO, Hiroyasu , MIYAUCHI, Kazuki , NOMOTO, Takahiro , TOMODA, Keishiro
IPC分类号： C08G65/333
摘要： Provided is a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells.
A degradable polyethylene glycol derivative represented by the following formula (1):
wherein m is 1 - 7, n1 and n2 are each independently 45 - 682, p is 1 - 4, R is an alkyl group having 1 - 4 carbon atoms, Z is an oligopeptide with 2 - 8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2 - 5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L 1 , L 2 , L 3 , L 4 and L 5 are each independently a single bond or a divalent spacer.-
公开(公告)号：EP3778628A1
公开(公告)日：2021-02-17
申请号：EP19776122.4
申请日：2019-03-29
发明人： YOSHIOKA, Hiroki , KAMIYA, Masaki , YAMAMOTO, Yuji , HIRAI, Midori , SASAKI, Akiko , NISHIYAMA, Nobuhiro , MATSUI, Makoto , TAKEMOTO, Hiroyasu , MIYAUCHI, Kazuki , NOMOTO, Takahiro , TOMODA, Keishiro
IPC分类号： C07K14/585 , A61K47/60 , A61P43/00 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/06 , C07K14/535 , C07K14/61 , C08G65/329
摘要： Provided is a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells.
A bio-related substance bonded to a degradable polyethylene glycol derivative, and represented by the following formula (A):
wherein m is 1 - 7, n1 and n2 are each independently 45 - 682, p is 1 - 4, R is an alkyl group having 1 - 4 carbon atoms, Z is an oligopeptide with 2 - 8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2 - 5 active hydrogens, D is the bio-related substance, L 1 , L 2 , L 3 , L 4 and L 5 are each independently a single bond or a divalent spacer, and y is 1 - 40.-
公开(公告)号：EP3950776A1
公开(公告)日：2022-02-09
申请号：EP20781870.9
申请日：2020-03-26
发明人： YOSHIOKA, Hiroki , OSAKAMA, Kazuki , HAMURA, Mika , INABA, Takanori , NISHIYAMA, Nobuhiro , MATSUI, Makoto , TAKEMOTO, Hiroyasu , NOMOTO, Takahiro , SUN, Xiaohang
IPC分类号： C08G65/333 , C08G81/00 , C08L101/16
摘要： An intracellularly degraded branched and degradable polyethylene glycol derivative represented by the following formula (1):
wherein each symbol is as defined in the present specification, that is used for modifying bio-related substances is provided by the present invention.-
公开(公告)号：EP3950703A1
公开(公告)日：2022-02-09
申请号：EP20783507.5
申请日：2020-03-26
发明人： YOSHIOKA, Hiroki , OSAKAMA, Kazuki , HAMURA, Mika , INABA, Takanori , NISHIYAMA, Nobuhiro , MATSUI, Makoto , TAKEMOTO, Hiroyasu , NOMOTO, Takahiro , SUN, Xiaohang
摘要： A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A):
wherein each symbol is as defined in the present specification, is provided by the present invention.
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