公开(公告)号：EP0013606B1

公开(公告)日：1984-05-02

申请号：EP80300038.9

申请日：1980-01-04

申请人： Key Pharmaceuticals, Inc.

发明人： Keith, Alec D. ,  Snipes, Wallace

IPC分类号： A61K9/22 ,  A61K9/26 ,  A61K9/70

CPC分类号： A61K9/7084 ,  A61K31/565

公开(公告)号：EP0013606A3

公开(公告)日：1981-01-07

申请号：EP80300038

申请日：1980-01-04

申请人： Key Pharmaceuticals, Inc.

发明人： Keith, Alec D. ,  Snipes, Wallace

IPC分类号： A61K09/20 ,  A61K09/26 ,  A61K09/70

CPC分类号： A61K9/7084 ,  A61K31/565

摘要： This invention provides a polymeric diffusion matrix comprising glycerol, polyvinylalcohol, a water-soluble polymer having hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and water. The matrix may further include a drug for topical or transdermal application to a patient. The invention also provides a method of making the polymeric diffusion matrix and a drug delivery device incorporating the matrix. The matrix may be used in the form of a package, which comprises the matrix (14) embedded in a backing member (10) provided with a detachable cover iayer (12). Before use, the cover layer is removed, and the backing member applied to the patient by means of a pressure-sensitive adhesive layer (26), so that the matrix (14) is held against the skin of the patient.

公开(公告)号：EP0013606A2

公开(公告)日：1980-07-23

申请号：EP80300038.9

申请日：1980-01-04

申请人： Key Pharmaceuticals, Inc.

发明人： Keith, Alec D. ,  Snipes, Wallace

IPC分类号： A61K9/22 ,  A61K9/26 ,  A61K9/70

CPC分类号： A61K9/7084 ,  A61K31/565

摘要： This invention provides a polymeric diffusion matrix comprising glycerol, polyvinylalcohol, a water-soluble polymer having hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and water. The matrix may further include a drug for topical or transdermal application to a patient. The invention also provides a method of making the polymeric diffusion matrix and a drug delivery device incorporating the matrix. The matrix may be used in the form of a package, which comprises the matrix (14) embedded in a backing member (10) provided with a detachable cover iayer (12). Before use, the cover layer is removed, and the backing member applied to the patient by means of a pressure-sensitive adhesive layer (26), so that the matrix (14) is held against the skin of the patient.

摘要翻译： 本发明提供一种聚合物扩散基质，其包含甘油，聚乙烯醇，具有水合位点的水溶性聚合物，其与剩余成分组合产生能够持续释放其中分散的药物的基质和水。 基质还可以包括用于局部或经皮施用于患者的药物。 本发明还提供了制备聚合物扩散基质的方法和掺入基质的药物递送装置。 该基质可以以包装的形式使用，其包括嵌入在具有可拆卸覆盖层（12）的背衬构件（10）中的基质（14）。 在使用之前，去除覆盖层，并且借助于压敏粘合剂层（26）将背衬构件施加到患者，使得基质（14）保持抵靠患者的皮肤。