-
公开(公告)号：EP0250187A3
公开(公告)日：1988-06-01
申请号：EP87305280
申请日：1987-06-15
CPC分类号： A61K9/006
摘要： A bioadhesive extruded single or multi-layered thin film, especially useful in intra-oral controlled-releasing delivery, having a water soluble or swellable polymer matrix bioadhesive layer which can adhere to a wet mucous surface and which bioadhesive layer consists essentially of 40-95% by weight of a hydroxypropyl cellulose, 5-60% of a homopolymer of ethylene oxide, 0-10% of a water-insoluble polymer such as ethyl cellulose, propyl cellulose, polyethylene and polypropylene, and 2-10% of a plasticizer, said film having incorporated therein a medicament, e.g., anesthetics, analgesics, anticaries agents, anti-inflammatories, antihistamines, antibiotics, antibacterials, fungistats, etc.
-
2.发明公开A gangliosides mixture, useful as a therapeutical tool for eliminating painful effects of peripheral neuropathies 失效一种抗菌药物混合物，有助于消除外周神经病变的副作用
公开(公告)号：EP0183572A3
公开(公告)日：1987-07-22
申请号：EP85401290
申请日：1985-06-26
申请人： FIDIA S.p.A.
CPC分类号： C07H15/10 , A61K31/70 , A61K2300/00
摘要： A ganglioside mixture, comprised of the gangliosides GM,, GD 1a , GD 1b and GT 1b , has been found to possess significant analgesic or pain relieving activity. The mixture is, therefore, useful for treating pain due to various peripheral neuropathies and the mixture is more effective than the individual gangliosides which comprise the mixture.
-
3.发明公开Compositions and method of controlling transdermal penetration of topical and systemic agents 失效控制局部和系统代谢物的渗透渗透的组合物和方法
公开(公告)号：EP0195643A3
公开(公告)日：1987-04-01
申请号：EP86301949
申请日：1986-03-17
CPC分类号： A61K9/7084 , A61K47/585
摘要： Compositions comprising a pharmacologically active drug together with a non-toxic pharmaceutically acceptable ion exchange resin, and a salt in a gel-forming vehicle, and topical administration thereof to human or animal skin.
-
4.发明公开Polymeric diffusion matrix, method of its preparation and drug delivery device comprising said matrix 失效聚合扩散矩阵，其制备方法及包含有效矩阵的药物递送装置
公开(公告)号：EP0013606A3
公开(公告)日：1981-01-07
申请号：EP80300038
申请日：1980-01-04
发明人： Keith, Alec D. , Snipes, Wallace
CPC分类号： A61K9/7084 , A61K31/565
摘要： This invention provides a polymeric diffusion matrix comprising glycerol, polyvinylalcohol, a water-soluble polymer having hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and water. The matrix may further include a drug for topical or transdermal application to a patient. The invention also provides a method of making the polymeric diffusion matrix and a drug delivery device incorporating the matrix. The matrix may be used in the form of a package, which comprises the matrix (14) embedded in a backing member (10) provided with a detachable cover iayer (12). Before use, the cover layer is removed, and the backing member applied to the patient by means of a pressure-sensitive adhesive layer (26), so that the matrix (14) is held against the skin of the patient.
-
5.发明公开Transdermal therapeutic systems for the administration of nalozone, naltrexone and nalbuphine 失效用于纳洛酮，纳洛酮和纳布铂的管理的超导治疗系统
公开(公告)号：EP0178140A3
公开(公告)日：1988-11-30
申请号：EP85307153
申请日：1985-10-07
申请人： ALZA CORPORATION
发明人： Cheng, Yu-Ling , Chun, Leslie T. , Enscore, David
CPC分类号： A61K9/7084 , A61K9/0014 , A61K31/485 , A61K47/14 , Y10S514/946
摘要： A method for transdermal delivery of naloxone, naltrexone and nalbuphine base through intact skin is described. Preferred embodiments of transdermal therapeutic systems for delivering these drugs and polyethylene glycol monolaurate employ an ethylene vinylacetate matrix containing drug base at a concentration above saturation and polyethylene glycol monolaurate below unit activity. Polyethylene glycol monolaurate is disclosed as a permeation enhancer for the base form of these drugs and is preferably delivered simultaneously with the drug.
-
公开(公告)号：EP0246809A3
公开(公告)日：1988-01-13
申请号：EP87304265
申请日：1987-05-13
CPC分类号： A61K9/0063 , A61K9/2063 , A61K9/7007
摘要： The present invention pertains to biodegradable sustained release pharmaceutical compositions. The compositions can be formed into implant devices which may be used to treat a wide variety of diseases and conditions. The implants are especially useful in treating diseases such such periodontal disease which require prolonged drug release.
-
7.发明公开
公开(公告)号：EP0130690A3
公开(公告)日：1986-07-30
申请号：EP84303611
申请日：1984-05-29
申请人： TEIJIN LIMITED
发明人： Suzuki, Yoshiki , Ikura, Hiroshi , Noguchi, Toshihide , Izumizawa, Katsunori , Kinoshita, Shiro
IPC分类号： A61K09/70
CPC分类号： A61K9/0063 , Y10S514/90 , Y10S514/902 , Y10S514/953
摘要： A pharmaceutical preparation for remedy of periodontal diseases, which is in the form of a film or sheet and is inserted in a periodontal pocket or gingiva, said pharmaceutical preparation comprising a water-soluble polymeric substance having a Young's modulus of 10 to 250 kg/mm 2 as determined at a temperature of 25°C and a relative humidity of 65%, and a viscosity of the 2% aqueous solution of 5 to 30,000 CP as determined at 20°C and a medicinal agent for remedy of periodontal diseases. This pharmaceutical preparation can be prepared by dissolving the above-mentioned water-soluble polymeric substance and medicinal agent in an organic solvent, casting the resultant solution, and removing the organic solvent by drying to obtain a pharmaceutical preparation in the form of a film or sheet.
-
公开(公告)号：EP0144486A3
公开(公告)日：1986-05-14
申请号：EP84103695
申请日：1984-04-04
CPC分类号： A61K9/7084 , A61K9/7092
摘要： @ The present invention is related to a pharmaceutical product preferably in medical bandage form, for the controlled release of a therapeutically active agent or several such agents to the skin. The pharmaceutical product of the invention consists of an impermeable backing layer, a particularly composed supersaturated reservoir layer for the therapeutically active agent connected therewith and comprising a polymer matrix wherein the therapeutically active agent is soluble and which is permeable to the active agent, an adhesive layer connected with the reservoir layer and permeable to said adhesive layer and removable therefrom for the use of the pharmaceutical product as transdermal therapeutic system, said reservoir layer for the therapeutically active agent consisting of a multitude of layers wherein the concentration of the therapeutically active agent increases from layer to layer with increasing distance from the adhesive layer, and process for producing such a pharmaceutical product.
-
公开(公告)号：EP0150428A3
公开(公告)日：1986-01-15
申请号：EP84115665
申请日：1984-12-18
申请人： BAYER AG
CPC分类号： A61K9/7053 , A61K9/7076
-
公开(公告)号：EP0155229A3
公开(公告)日：1985-12-11
申请号：EP85810072
申请日：1985-02-22
CPC分类号： A61K31/425 , A61K9/7061 , A61K9/7084 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/48
摘要： The present invention provides a pharmaceutical composition for the transdermal systemic administration of an active agent characterised in that the active agent is bopindolol or methysergide. Also the present invention provides a pharmaceutical composition for the transdermal systemic administration of a pharmacologically active agent characterised in that it contains bopindolol, tizanidine, clemastine, ketotifen or methysergide as active agent in a reservoir comprising a hydrophilic polymer. Furthermore a pharmaceutical composition for the transdermal systemic administration of pharmacologically active agents characterised in that the pharmacologically active agent is in a reservoir comprising a polyacrylate polymer containing cationic ester groups.
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.007 秒)
