公开(公告)号：EP0957161A1

公开(公告)日：1999-11-17

申请号：EP97949237.8

申请日：1997-12-25

申请人： Kirin Brewery Company, Ltd.

发明人： KOEZUKA, Y. Kirin Brewery Company, Ltd. ,  YAMAGUCHI, Y. Kirin Brewery Company, Ltd ,  MOTOKI, K. Kirin Brewery Company, Ltd.

IPC分类号： C12N5/22 ,  C07H15/04 ,  A61K35/14 ,  A61K35/28 ,  A61K35/36

CPC分类号： C07H15/04 ,  A61K2039/5154 ,  C12N5/0639 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/90

摘要： A method for activating human antigen presenting cells characterized by culturing in vitro antigen presenting cells with a human origin together with at least one of glycoside compounds represented by general formula (A) or salts thereof preferably exemplified by (2S, 3S, 4R)-1-(α-D-galactopyranosyloxy)-2-hexacosanoylamino-3,4-octadecanediol; the human antigen presenting cells thus activated; methods for treating cancer or infectious diseases such as AIDS by using activated human antigen presenting cells; and the use of activated human antigen presenting cells in the production of drugs for treating these diseases. Thus, sufficient therapeutic effects can be achieved on cancer and infectious diseases such as AIDS without effecting any pulse therapy with the use of tumor antigens.

摘要翻译： 一种用于激活通过在体外培养的抗原与由通式（A）代表的糖苷化合物中的至少一种呈递细胞与人源一起表征的人抗原呈递细胞或其盐优选通过（2S，3S，4R）例举方法-1 - （α-D-半乳糖吡喃糖基）-2-二十六烷基-3,4-十八烷二醇; 人抗原呈递细胞如此活化; 方法用于治疗癌症或感染性疾病：通过使用活化的人的抗原呈递细胞，如艾滋病; 并在生产药物的用途激活的人体的抗原呈递细胞用于治疗疾病的论文。 因此，足够的治疗效果可在癌症和感染性疾病来实现：例如AIDS，而不会影响任何脉冲疗法与使用肿瘤抗原。