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公开(公告)号：EP3466932A1
公开(公告)日：2019-04-10
申请号：EP17806528.0
申请日：2017-05-25
IPC分类号： C07D239/26 , C07D241/12
摘要： Developed is a technique according to which a nitrogen-containing bicyclic heterocyclic compound can be manufactured directly from nitrogen-containing heterocyclic compounds in a short period of time through a small number of steps without using expensive agents and a starting material that takes time and effort to synthesize. A method for manufacturing a nitrogen-containing bicyclic heterocyclic compound includes a synthesis step of synthesizing a nitrogen-containing bicyclic heterocyclic compound such as bipyrimidine, bipyrazine, or biquinoline by reacting, in a reaction solvent, one nitrogen-containing heterocyclic compound and another nitrogen-containing heterocyclic compound with a solution containing an alkali metal.
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2.发明公开
公开(公告)号：EP3360861A1
公开(公告)日：2018-08-15
申请号：EP16853732.2
申请日：2016-10-07
IPC分类号： C07D213/127 , C07D213/22
CPC分类号： C07D213/22 , B01D9/0004 , B01D9/005 , B01J23/04 , C07D213/127
摘要： A target bipyridine compound is synthesized with high purity and a high yield in a simple and safe manner in a short period of time. A method for synthesizing a di-tert-butyl-2,2'-bipyridine compound is provided, and the method includes a step of reacting, in a reaction solvent, a tert-butylpyridine compound with a dispersion product obtained by dispersing an alkali metal in a dispersion solvent. A method for synthesizing a bipyridine compound having no substituents is also provided, and the method includes a step of reacting, in a reaction solvent, pyridine with a dispersion product obtained by dispersing an alkali metal in a dispersion solvent.
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3.发明公开
公开(公告)号：EP3733678A1
公开(公告)日：2020-11-04
申请号：EP18897718.5
申请日：2018-12-27
摘要： An object is to establish a technology with which an organic magnesium compound can be easily and efficiently synthesized at a low cost with few steps that do not involve a complex chemical method. A method for synthesizing an organic magnesium compound includes, in a reaction solvent, reacting an organic halide represented by General Formula I (R a -X a ) with a dispersion product obtained by dispersing sodium in a dispersion solvent to obtain an organic sodium compound represented by General Formula II (R a -Na), and reacting the obtained organic sodium compound with a magnesium halide represented by General Formula III (Mg-(X b ) 2 ) to obtain an organic magnesium compound represented by General Formula IV (R a -Mg-X b ).
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4.发明公开
公开(公告)号：EP3466927A1
公开(公告)日：2019-04-10
申请号：EP17806527.2
申请日：2017-05-25
IPC分类号： C07D213/16 , C07D213/22 , C07D213/61
摘要： There is a demand for the development of a technique according to which a reaction for coupling a halogenated pyridine compound with a halogenated aromatic compound can be performed in a simple manner through a small number of steps without using expensive agents such as a palladium catalyst. A method for coupling a halogenated pyridine compound with a halogenated aromatic compound includes a step of coupling a halogenated pyridine compound with a halogenated aromatic compound to obtain a pyridine compound by reacting, in a reaction solvent, the halogenated pyridine compound and the halogenated aromatic compound with a solution containing an alkali metal.
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