公开(公告)号：EP3390351A1

公开(公告)日：2018-10-24

申请号：EP16826714.4

申请日：2016-12-19

申请人： Koester, Hubert

发明人： VON KLEIST, Lisa ,  MICHAELIS, Simon ,  BARTHO, Kathrin ,  SCHLIEF, Marén ,  DREGER, Mathias ,  SCHREY, Anna K. ,  SEFKOW, Michael ,  KROLL, Friedrich ,  KÖSTER, Hubert ,  OHLENDORF, Daniel ,  LUO, Yan

IPC分类号： C07C271/20 ,  C07C271/22 ,  C07C235/66 ,  C07C237/10 ,  A61K31/166 ,  A61K31/325 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07C235/66 ,  C07C235/74 ,  C07C237/10 ,  C07C271/20 ,  C07C271/22 ,  C07C2601/14

摘要： The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is -OH, R2 is -NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, -CONH2, and -CONR9 2, and the other one is selected from -CONR9 2 and -CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off- target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.