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公开(公告)号：EP2280650A1
公开(公告)日：2011-02-09
申请号：EP09750236.3
申请日：2009-05-15
摘要： The present invention relates to an imaging apparatus for generating an image of a region of interest. The imaging apparatus comprises a radiation source (2), a detection unit (6) for generating detection data and a moving unit (1, 7, 8) for moving the radiation source (2) and the region of interest relative to each other, while the detection data are generated. The imaging apparatus further comprises an identification unit (13) for identifying in the detection data high density detection data and non-high density detection data. A density weighting unit (14) density weights the detection data, wherein at least a part of the high density detection data has a smaller density weight than the non-high density detection data, and a reconstruction unit (15) reconstructs an image of the region of interest from the weighted detection data.
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2.发明公开IMAGING SYSTEM, IMAGING METHOD AND COMPUTER PROGRAM FOR IMAGING A REGION OF INTEREST 有权为了说明的感兴趣区域成像系统，成像方法和计算机程序
公开(公告)号：EP2076885A1
公开(公告)日：2009-07-08
申请号：EP07826718.4
申请日：2007-10-12
发明人： KOEHLER, Thomas , PROKSA, Roland
IPC分类号： G06T11/00
CPC分类号： G06T11/005 , G06T2211/421
摘要： The present invention relates to an imaging system for imaging a region of interest comprising an illumination unit and a detection unit. The imaging system further comprises a grouping unit for grouping the detection values, wherein each group comprises at least one alpha detection value and at least one beta detection value (103). At least one alpha aperture weighting value for the at least one alpha detection value of a group is determined by using at least one position of at least one ray within the aperture (104). Furthermore, at least one beta aperture weighting value for the at least one beta detection value of a group is approximately determined using the at least one alpha aperture weighting value of the group (105). The detection values are than aperture weighted using aperture weighting values (106). The region of interest is reconstructed by backprojecting the weighted detection values (107).
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公开(公告)号：EP2040609A1
公开(公告)日：2009-04-01
申请号：EP07789796.5
申请日：2007-06-25
发明人： NIELSEN, Tim , KOEHLER, Thomas
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： A device for determining a concentration-related quantity of a fluorescent contrast agent applied to an object (2), in particular a turbid medium. Said device generally comprises a source (4) of electromagnetic radiation for irradiating the object (2) at an excitation wavelength and at least one first detecting means (6, 7.1, 7.2,..., 8) for detecting fluorescent electromagnetic radiation emitted by the contrast agent at a fluorescence wavelength, said first detecting means producing fluorescence intensity data (F). The proposed device further comprises at least one second detecting means (6, 7.1, 7.2,...) for detecting electromagnetic radiation transmitted by the object (2) at the excitation wavelength, said second detecting means producing transmission intensity data (T), and evaluating means (10) adapted to receive the transmission intensity data and the fluorescence intensity data and to determine said concentration-related quantity of the contrast agent from a ratio (R) of fluorescence intensity data and transmission intensity data.
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公开(公告)号：EP2612299A1
公开(公告)日：2013-07-10
申请号：EP11764000.3
申请日：2011-09-01
发明人： KOEHLER, Thomas , RÖSSL, Ewald
IPC分类号： G06T11/00
CPC分类号： G06T11/003 , A61B6/484 , G06T11/005 , G06T11/006
摘要： The present invention relates to differential phase-contrast imaging of an object (108). When reconstructing image information from differential phase-contrast image data, streak- like artefacts (502) may occur. The artefacts (502) may substantially reduce legibility of reconstructed image data. Accordingly, it may be beneficial for removing or at least suppressing said artefacts (502). Thus, a method (400) for regularized phase retrieval in phase-contrast imaging is provided comprising receiving (402) differential phase-contrast image data of an object (108); generating (404) reconstructed image data of an object (108) and presenting (406) reconstructed image data of the object (108). The differential phase-contrast image and the reconstructed image data comprise a two-dimensional data structure having a first dimension and a second dimension. Generating reconstructed image data comprises integration of image data in one of the first dimension and the second dimension of the data structure. A gradient operator is determined in the other one of the first dimension and second dimension of the data structure and the data structure is employed for reconstructing image data resulting in a reduction of artefacts (500) within the reconstructed image data.
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公开(公告)号：EP2611364A1
公开(公告)日：2013-07-10
申请号：EP11760576.6
申请日：2011-08-26
发明人： KOEHLER, Thomas
CPC分类号： G21K1/067 , A61B6/032 , A61B6/4035 , A61B6/4291 , A61B6/484 , G01N23/04 , G21K1/02 , G21K2207/005
摘要： The present invention relates to differential phase-contrast imaging of an object. For increasing spatial resolution of an X-ray imaging system (2) the size of a detector pixel element (8) may be considered a limiting factor. Accordingly, it may be beneficial to increase the resolution of an apparatus (38) for phase-contrast imaging without further reducing the area of an individual pixel element (8). Accordingly, an apparatus (38) for phase-contrast imaging with improved sampling is provided, comprising an X-ray source (4), a first grating element G1 (24), a second grating element G2 (26) and an X-ray detector element (6) comprising a plurality of detector pixel elements (8), each detector pixel element (8) having a pixel area A. An object to be imagined (14) is arrangeable between the X-ray source (4) and the X-ray detector element (6). The first grating element G1 (24) as well as the second grating element G2 (26) are arrangeable between the X-ray source (4) and the X-ray detector element (6). The X-ray source (4), the first grating element G1 (24), the second grating element G2 (26) and the X-ray detector (6) are operatively coupled for acquisition of a phase-contrast image of the object (14). At least one of the first grating element G1 (24) and the second grating element G2 (26) comprise a first area A1 having a first grating pitch p1 and a second area A2 having a second grating pitch p2 different from the first grating pitch.
摘要翻译： 本发明涉及对象的差分相位对比成像。 为了增加X射线成像系统的空间分辨率（2），检测器像素元件（8）的尺寸可以被认为是限制因素。 因此，增加用于相位对比成像的装置（38）的分辨率可能是有益的，而不进一步减小单个像素元件（8）的面积。 因此，提供了一种用于具有改进的采样的相位对比成像的装置（38），包括X射线源（4），第一光栅元件G1（24），第二光栅元件G2（26）和X射线 检测器元件（6）包括多个检测器像素元件（8），每个检测器像素元件（8）具有像素区域A.要想象的物体（14）可布置在X射线源（4）和 X射线检测元件（6）。 第一光栅元件G1（24）以及第二光栅元件G2（26）可配置在X射线源（X）和X射线探测元件（6）之间。 X射线源（4），第一光栅元件G1（24），第二光栅元件G2（26）和X射线检测器（6）可操作地耦合以获取对象的相位对比度图像 14）。 第一光栅元件G1（24）和第二光栅元件G2（26）中的至少一个包括具有第一光栅间距p1的第一区域A1和具有与第一光栅间距不同的第二光栅间距p2的第二区域A2。
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6.发明公开APPARATUS FOR PHASE-CONTRAST IMAGING COMPRISING A DISPLACEABLE X-RAY DETECTOR ELEMENT AND METHOD 有权设备技术采用了侧滑射线探测器元件和方法相衬成像
公开(公告)号：EP2509503A1
公开(公告)日：2012-10-17
申请号：EP10807374.3
申请日：2010-12-03
发明人： ROESSL, Ewald , ENGEL, Klaus J. , VOGTMEIER, Gereon , GELLER, Dieter , MARTENS, Gerhard , KOEHLER, Thomas , SCHUSSER, Sebastian, Siegmund
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4021 , A61B6/4092 , A61B6/4291 , A61B6/484
摘要： The present invention relates to X-ray image acquisition technology in general. Employing phase-contrast imaging for X-ray image acquisition may significantly enhance the quality and information content of images acquired. However, phase- contrast information may only be obtainable in a small detector region, possibly being too small for a sufficient field of view for specialized X-ray imaging applications. Accordingly, an apparatus for phase-contrast imaging is provided that may allow the acquisition of an enlarged field of view. According to the present invention an apparatus (1) for phase-contrast imaging is provided, comprising an X-ray source (2), an X-ray detector (12) element having a detector size, a beam splitter grating (8) and an analyzer grating (10). An object (6) is arrangeable between the X-ray source (2) and the X-ray detector (12). The beam splitter grating (8) and the analyzer grating (10) are arrangeable between the X-ray source (2) and the X-ray detector (12). X-ray source (2), the beam splitter grating (8), the analyzer grating (10) and the X-ray detector (12) are operatively coupled such that a phase-contrast image of the object (6) is obtainable. The apparatus (1) is adapted for acquiring a phase-contrast image having a field of view larger than the detector size. The X-ray detector element (12) is displaceable and by the displacement of the X-ray detector (12) a phase-contrast image of the field of view is obtainable.
摘要翻译： 一种X射线图像采集装置用人相衬成像的视场放大包括X射线源到具有检测器尺寸，分束器光栅和上分析器光栅的X射线检测器元件。 一个目的是在X射线源和检测器之间可布置。 分束器光栅和分析器光栅是在X射线源和检测器之间可布置。 的X射线源，所述射束分裂器光栅，所述分析器光栅和X射线检测器可操作地耦合检查没有所述对象的相位对比图像可获得A. 该装置是配置为获取具有的视野比检测器尺寸大的一个领域，相位对比图像。 X射线检测器元件是可移动的，其中，由X射线检测器的位移，所述视场放大的相位对比图像可获得A.
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公开(公告)号：EP2509487A1
公开(公告)日：2012-10-17
申请号：EP10807737.1
申请日：2010-12-08
IPC分类号： A61B1/00
CPC分类号： A61B6/4291 , A61B6/4092 , A61B6/484 , A61B6/583 , G21K2207/005
摘要： The present invention relates to an X-ray imaging system and a method for differential phase—contrast imaging of an object. To improve calibration of differential phase—contrast imaging systems and the alignment of the gratings an X-ray imaging system is provided that comprises an X-ray emitting arrangement providing at least partially coherent X-ray radiation and an X-ray detection arrangement comprising a phase-shift diffraction grating, a phase analyzer grating, and an X-ray image detector, all arranged along an optical axis. For stepping, the gratings and/or the X-ray emitting arrangement are provided with at least two actuators arranged opposite to each other with reference to the optical axis. For calibration, calibration projections are acquired without an object, wherein, the emitted X-ray radiation or one of the gratings is stepwise displaced with a calibration displacement value. For examination, measurement projections are acquired with an object, wherein the emitted X-ray radiation or one of the gratings is stepwise displaced with a measurement, a calibration projection is associated to each of the measurement projections by registering the latter with the calibration projections.
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公开(公告)号：EP2476099A1
公开(公告)日：2012-07-18
申请号：EP10757275.2
申请日：2010-09-01
IPC分类号： G06T11/00
CPC分类号： G06T11/005 , A61B6/5258 , G06T2211/412
摘要： The invention relates to a projection values processing apparatus (1) for processing acquired projection values. A first image is reconstructed from acquired projection values under consideration of a reconstruction assumption by a reconstruction unit (13). A simulated projection values determining unit (14) determines simulated projection values by simulating a projection through the reconstructed first image under consideration of the reconstruction assumption, and inconsistency values are determined for the acquired projection values by an inconsistency determining unit (15), wherein an inconsistency value is indicative of a degree of inconsistency of a respective acquired projection value with the reconstruction assumption, by comparing the acquired projection values and the simulated projection values. The inconsistency values can be used for different purposes, for example, improving the quality of a reconstructed image or indicating image elements being affected by an inconsistency between reconstruction assumption and acquired projection values.
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公开(公告)号：EP2433288A1
公开(公告)日：2012-03-28
申请号：EP10726271.9
申请日：2010-05-17
发明人： KOEHLER, Thomas , ROESSL, Ewald
IPC分类号： G21K1/06
CPC分类号： G21K1/06 , G21K2207/005
摘要： The invention relates to gratings for X-ray differential phase-contrast imaging, a focus detector arrangement and X-ray system for generating phase-contrast images of an object and a method of phase-contrast imaging for examining an object of interest. In order to provide gratings with a high aspect ratio but low costs, a grating for X-ray differential phase-contrast imaging is proposed, comprising a first sub-grating (112), and at least a second sub-grating (114; 116; 118), wherein the sub-gratings each comprise a body structure (120) with bars (122) and gaps (124) being arranged periodically with a pitch (a), wherein the sub-gratings (112; 114; 116; 118) are arranged consecutively in the direction of the X-ray beam, and wherein the sub-gratings (112; 114; 116; 118) are positioned displaced to each other perpendicularly to the X-ray beam.
摘要翻译： 本发明涉及用于X射线差分相位对比成像的光栅，用于产生对象的相位对比图像的焦点检测器装置和X射线系统以及用于检查感兴趣对象的相位对比成像方法。 为了提供具有高纵横比但成本较低的光栅，提出了一种用于X射线差分相位对比成像的光栅，包括第一子光栅（112）和至少第二子光栅（114; 116 ; 118），其中所述子光栅各自包括具有杆（122）和间隙（124）的主体结构（120），所述杆具有间距（a）周期性地布置，其中所述子光栅（112; 114; 116; 118 ）沿X射线束的方向连续布置，并且其中子光栅（112; 114; 116; 118）被定位成垂直于X射线束彼此位移。
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公开(公告)号：EP2395905A1
公开(公告)日：2011-12-21
申请号：EP10703524.8
申请日：2010-02-05
发明人： KOEHLER, Thomas
CPC分类号： A61B6/484 , A61B5/0091 , A61B6/0414 , A61B6/502 , A61B8/0825
摘要： The invention relates to imaging systems in which during imaging of an object a matching medium is used to match the object to its surroundings. An interface device is used for phase contrast rim-imaging of the object, which comprises a compartment in which a deformable matching material is contained which can be pushed to the side when the object to be imaged is compressed. Thus, a lateral field of view for X-ray phase contrast mammography may be increased.
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