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    MODEL MOUSE OF ATTENTION DEFICIT HYPERACTIVITY DISORDER, METHOD FOR INVESTIGATING EFFECTS FOR PREVENTING AND ALLEVIATING ATTENTION DISORDER USING THE MODEL MOUSE, AND METHOD FOR TREATING ATTENTION DISORDER BY SUPPRESSING T-TYPE CALCIUM CHANNEL
    1.
    发明公开
    MODEL MOUSE OF ATTENTION DEFICIT HYPERACTIVITY DISORDER, METHOD FOR INVESTIGATING EFFECTS FOR PREVENTING AND ALLEVIATING ATTENTION DISORDER USING THE MODEL MOUSE, AND METHOD FOR TREATING ATTENTION DISORDER BY SUPPRESSING T-TYPE CALCIUM CHANNEL 审中-公开
    模型小鼠用于注意缺陷障碍/多动，METHOD FOR影​​响用于预防注意力缺陷障碍的审查和RELIEF使用用于注意缺陷障碍的治疗模型小鼠和方法通过钙还原CHANNEL中的T

    公开(公告)号：EP2604109A1

    公开(公告)日：2013-06-19

    申请号：EP11816513.3

    申请日：2011-01-21

    申请人： Korea Advanced Institute Of Science And Technology

    发明人： KIM, Daesoo ,  KIM, Jeongjin

    IPC分类号： A01K67/027 ,  G01N33/15 ,  A61B5/0476 ,  A61P25/00

    CPC分类号： G01N33/5088 ,  A01K67/027 ,  A01K2207/30 ,  A01K2227/105 ,  A01K2267/0356 ,  A61B5/0476 ,  A61B5/168 ,  A61B5/6897

    摘要： The present invention relates to an Attention deficit and hyperactivity disorder(ADHD) mouse model and a screening method for a composition for the prevention and treatment of attention deficit disease. The mouse model constructed by inserting cobalt wire in the right side of the frontal lobe is very useful as the ADHD mouse model, and the said ADHD mouse model can be effectively used for the screening of an agent for the treatment of attention deficit disease since the mouse demonstrated brain wave with low frequency, hyperactivity, and cognitive impairment, which are characteristic symptoms of attention deficit disease, when ethosuximide, one of T-type calcium channel blockers, was administered. Therefore, the composition comprising a T-type calcium channel blocker was also confirmed to be effectively used for the prevention and treatment of attention deficit disease.

    摘要翻译： 本发明涉及到对注意力缺陷多动障碍（ADHD）小鼠模型和用于预防和治疗注意力缺陷疾病的组合物的筛选方法。 通过在额叶的右侧插入钴丝构建的小鼠模型是作为ADHD小鼠模型是非常有用的，并且所述ADHD小鼠模型可有效地用于药物的筛选，因为治疗注意力缺陷疾病的 鼠标实例阐述脑波与低频，多动，和认知功能障碍，其是注意力缺陷疾病的特征症状，当乙琥胺，T型钙通道阻断剂，其施用之一。 因此，为了有效地用于预防和治疗注意力缺陷疾病，包括T型钙通道阻断剂，其由此证实了组合物。