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1.发明公开2,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权2,7-取代THIEN [3,2-d]嘧啶化合物作为蛋白激酶抑制剂
公开(公告)号：EP2491043A2
公开(公告)日：2012-08-29
申请号：EP10825157.0
申请日：2010-10-15
发明人： SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , HAM, Young Jin , JUN, Eun Jin , LEE, Jung Hun , KIM, Hwan
IPC分类号： C07D495/04 , C07D495/02 , A61K31/505 , A61P35/00
CPC分类号： C07D495/04 , C07D519/00
摘要： Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.
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2.发明授权2,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权2,7-取代THIEN [3,2-d]嘧啶化合物作为蛋白激酶抑制剂
公开(公告)号：EP2491043B1
公开(公告)日：2014-07-16
申请号：EP10825157.0
申请日：2010-10-15
发明人： SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , HAM, Young Jin , JUN, Eun Jin , LEE, Jung Hun , KIM, Hwan
IPC分类号： C07D495/04 , C07D495/02 , A61K31/505 , A61P35/00
CPC分类号： C07D495/04 , C07D519/00
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3.发明公开BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE 审中-公开具有锁定效应蛋白激酶双环杂芳基衍生物
公开(公告)号：EP2528920A2
公开(公告)日：2012-12-05
申请号：EP11737311.8
申请日：2011-01-28
发明人： JUNG, Seung Hyun , JUNG, Young Hee , CHOI, Wha Il , SON, Jung Beom , JEON, Eun Ju , YANG, In Ho , SONG, Tae Hun , LEE, Mi Kyoung , KO, Myoung Sil , AHN, Young Gil , KIM, Maeng Sup , HAM, Young Jin , SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , PARK, Dong-sik , KIM, Hwan
IPC分类号： C07D487/04 , C07D495/04 , A61K31/519 , A61P43/00
CPC分类号： C07D495/04
摘要： The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.
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