公开(公告)号：EP3418275A1

公开(公告)日：2018-12-26

申请号：EP17753486.4

申请日：2017-02-16

申请人： Korea Institute of Science and Technology ,  Daegu-Gyeongbuk Medical Innovation Foundation

发明人： SIM, Tae Bo ,  HUR, Woo Young ,  SONG, Chi Man ,  YOON, Ho Jong ,  CHOI, Seung Hye ,  CHO, Han Na ,  CHOI, Hwan Geun ,  KIM, Nam Doo ,  SON, Jung Beom ,  KO, Eun Hwa ,  KIM, Hyun Kyoung ,  CHO, Joong Heui ,  KANG, Seock Yong ,  KIM, So Young ,  KO, Yi Kyung ,  LEE, Seung Yeon ,  YOON, Suk Kyoon ,  BAE, Jae Hyun

IPC分类号： C07D333/10 ,  C07D409/12 ,  A61K31/381 ,  A61K31/4436

CPC分类号： A61K31/381 ,  A61K31/4436 ,  C07D333/10 ,  C07D409/12 ,  Y02P20/55

摘要： The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.

公开(公告)号：EP4092029A1

公开(公告)日：2022-11-23

申请号：EP20913360.2

申请日：2020-07-14

申请人： Korea Institute of Science and Technology

发明人： SIM, Tae Bo ,  CHO, Han Na ,  CHOI, Seung Hye ,  HUR, Woo Young ,  SONG, Chi Man ,  LEE, Ji Hoon ,  LEE, Jung Yeol ,  PARK, Sun You ,  CHOI, Myeong A ,  JOO, Jeong Min

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

摘要： The present disclosure relates to a 7-amino-3,4-dihydropyrimidopyrimidin-2-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anti-cancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.

公开(公告)号：EP4190331A1

公开(公告)日：2023-06-07

申请号：EP21850952.9

申请日：2021-07-30

申请人： Pharos Ibio Co., Ltd. ,  Korea Institute of Science and Technology

发明人： SIM, Tae Bo ,  CHOI, Seung Hye ,  CHO, Han Na ,  KIM, Nam Kyoung ,  HUR, Woo Young ,  SONG, Chi Man ,  NAM, Ky Youb ,  YOON, Jeong Hyeok

IPC分类号： A61K31/4535 ,  A61P35/00 ,  A23L33/10

摘要： The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of gastrointestinal stromal tumor. The 2,3,5-substituted thiophene compound exhibits high inhibitory activity against the growth of gastrointestinal stromal tumor, and thus may be effectively used for the prevention, amelioration or treatment of gastrointestinal stromal tumor.

公开(公告)号：EP4105213A1

公开(公告)日：2022-12-21

申请号：EP20914046.6

申请日：2020-07-14

申请人： Korea Institute of Science and Technology

发明人： SIM, Tae Bo ,  PARK, Chan Sun ,  CHOI, Seung Hye ,  CHO, Han Na ,  SENGUPTA, Sandip ,  SHIN, In Jae ,  HUR, Woo Young ,  KUMAR, Jayprakash Narayan

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61P35/00

摘要： The present invention relates to a pyrido[[3,4- d ]pyrimidine derivative compound showing excellent antiproliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition for cancer cells. The compound exhibits excellent inhibitory activity and antiproliferative efficacy against cancer cells, and thus the compound is useful not only for inhibiting cancer cells, but also for preventing cancer metastasis and proliferative diseases or for treating cancer.

公开(公告)号：EP3929195A1

公开(公告)日：2021-12-29

申请号：EP20759694.1

申请日：2020-02-17

申请人： Korea Institute of Science and Technology

发明人： SIM, Tae Bo ,  HUR, Woo Young ,  SONG, Chi Man ,  SENGUPTA, Sandip ,  PARK, Chan Sun ,  CHOI, Seung Hye ,  CHO, Han Na ,  SHIN, In Jae

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00

摘要： The present disclosure relates to a pyrido[3,4-d]pyrimidin-8-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.

公开(公告)号：EP4190330A1

公开(公告)日：2023-06-07

申请号：EP21849180.1

申请日：2021-07-30

申请人： Pharos Ibio Co., Ltd. ,  Korea Institute of Science and Technology

发明人： SIM, Tae Bo ,  CHOI, Seung Hye ,  CHO, Han Na ,  HUR, Woo Young ,  SONG, Chi Man ,  NAM, Ky Youb ,  YOON, Jeong Hyeok

IPC分类号： A61K31/4535 ,  A61P3/04 ,  A23L33/10

摘要： The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of mastocytosis. The 2,3,5-substituted thiophene compound has excellent inhibitory activity against the growth of mastocytosis cells and against an inflammatory response caused by mastocytosis, and thus may be effectively used for the prevention, amelioration or treatment of mastocytosis.