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1.发明公开HANSENULA POLYMORPHA YAPSIN DEFICIENT MUTANT STRAIN AND PROCESS FOR THE PREPARATION OF RECOMBINANT PROTEINS USING THE SAME 有权多形汉逊和方法的YAPSIN亏突变株FOR SO生产重组蛋白的
公开(公告)号：EP1534835A1
公开(公告)日：2005-06-01
申请号：EP03736354.6
申请日：2003-06-28
申请人： Korea Research Institute of Bioscience and Biotechnology , Leadbio Inc. , Bioholdings Co., Ltd.
发明人： KANG, Hyun-Ah , RHEE, Sang-Ki , SOHN, Min-Jeong , KIM, Jeong-Yoon
IPC分类号： C12N15/31
CPC分类号： C12N9/58 , C07K2319/02 , C12N15/815 , C12P21/02 , C12P21/06
摘要： The present invention relates to polynucleotide containing HpYPS1 gene coding Hansenula polymorpha yapsin1; polypeptide coded thereby; Hansenula polymorpha mutant wherein yapsin activity is reduced by the mutation of the HpYPS1 gene coding Hansenula polymorpha yapsin1; recombinant Hansenula polymorpha strain expressing a foreign protein prepared by introducing a gene coding a foreign protein to the Hansenula polymorpha mutant; and a method for preparing a foreign protein comprising the steps of culturing the recombinant Hansenula polymorpha strain under the condition that the foreign protein can be expressed, and isolating the foreign protein from the obtained culture broth.
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2.发明授权HANSENULA POLYMORPHA YAPSIN DEFICIENT MUTANT STRAIN AND PROCESS FOR THE PREPARATION OF RECOMBINANT PROTEINS USING THE SAME 有权多形汉逊和方法的YAPSIN亏突变株FOR SO生产重组蛋白的
公开(公告)号：EP1534835B1
公开(公告)日：2010-09-08
申请号：EP03736354.6
申请日：2003-06-28
申请人： Korea Research Institute of Bioscience and Biotechnology , Leadbio Inc. , Bioholdings Co., Ltd.
发明人： KANG, Hyun-Ah , RHEE, Sang-Ki , SOHN, Min-Jeong , KIM, Jeong-Yoon
IPC分类号： C12N15/31
CPC分类号： C12N9/58 , C07K2319/02 , C12N15/815 , C12P21/02 , C12P21/06
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3.发明公开GLUCONOBACTER SUBOXYDANS SORBITOL DEHYDROGENASE, GENES AND METHODS OF USE THEREOF 审中-公开葡萄糖酸菌山梨糖醇，基因与应用方法
公开(公告)号：EP1177302A1
公开(公告)日：2002-02-06
申请号：EP99913530.4
申请日：1999-04-23
申请人： ARCHER DANIELS MIDLAND COMPANY , Komitech , Korea Research Institute of Bioscience and Biotechnology
发明人： CHOI, Eui-Sung , RHEE, Sang-Ki , LEE, Eun-Hae
摘要： The invention relates to the fields of molecular biology, bacteriology and industrial fermentation. More specifically, the invention provides isolated nucleic acid molecules encoding the three subunits of a novel, membrane-bound, Gluconobacter oxydans sorbitol dehydrogenase (SDH) of the invention and vectors and host cells containing said isolated nucleic acid molecules. The invention further provides isolated polypeptides for the three subunits of the SDH enzyme of the invention, and processes for the production of L-sorbose and 2-keto-L-gulonic acid.
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