公开(公告)号：EP2886556A2

公开(公告)日：2015-06-24

申请号：EP13824875.2

申请日：2013-08-05

申请人： Korea Research Institute of Bioscience and Biotechology ,  SNU R&DB Foundation

发明人： KIM, Se Mi ,  KIM, Sang Jick ,  MIN, Hye Jin ,  SONG, Jin Myeong ,  LEE, Jung Weon ,  KIM, Hye Jin ,  AHN, Hye Mi ,  CHOI, In Pyo ,  RYU, Ji Hye

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  G01N33/574

CPC分类号： C07K16/2863 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/577 ,  G01N2333/4703

摘要： The present invention relates to a novel monoclonal antibody which is specifically bound to a transmembrane 4 L six family member 5 (TM4SF5) protein. More particularly, the present invention relates to a monoclonal antibody which is specifically bound to a human TM4SF5 protein, to polynucleotides coding for the monoclonal antibody, to an expression vector comprising the nucleotides, to a transformant with the vector introduced thereto, to a method for preparing the monoclonal antibody, to a composition comprising the monoclonal antibody, to a method for treating cancer using the monoclonal antibody, to a method for inhibiting liver metastasis of cancer, to a method for diagnosing cancer using the monoclonal antibody and to a cancer diagnosis kit comprising the monoclonal antibody.

摘要翻译： 本发明涉及一种新的单克隆抗体的所有其特异性地结合到一个跨膜4升6名家族成员5（TM4SF5）的蛋白质。 更具体地，本发明涉及一种单克隆抗体的所有其特异性地结合于人TM4SF5蛋白，多核苷酸编码的单克隆抗体，在表达载体，其包含的核苷酸，与引入其中的载体的转化体，一种用于方法 制备单克隆抗体，其包含单克隆抗体的组合物，一种用于使用所述单克隆抗体治疗癌症，一种用于抑制癌症的肝脏转移，一种方法，用于使用所述单克隆抗体诊断癌症和癌症诊断试剂盒 包括单克隆抗体。

公开(公告)号：EP2886556B1

公开(公告)日：2018-01-17

申请号：EP13824875.2

申请日：2013-08-05

申请人： Korea Research Institute of Bioscience and Biotechnology ,  SNU R&DB Foundation

发明人： KIM, Se Mi ,  KIM, Sang Jick ,  MIN, Hye Jin ,  SONG, Jin Myeong ,  LEE, Jung Weon ,  KIM, Hye Jin ,  AHN, Hye Mi ,  CHOI, In Pyo ,  RYU, Ji Hye

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  G01N33/574

CPC分类号： C07K16/2863 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/577 ,  G01N2333/4703

摘要： The present invention relates to a novel monoclonal antibody which is specifically bound to a transmembrane 4 L six family member 5 (TM4SF5) protein. More particularly, the present invention relates to a monoclonal antibody which is specifically bound to a human TM4SF5 protein, to polynucleotides coding for the monoclonal antibody, to an expression vector comprising the nucleotides, to a transformant with the vector introduced thereto, to a method for preparing the monoclonal antibody, to a composition comprising the monoclonal antibody, to a method for treating cancer using the monoclonal antibody, to a method for inhibiting liver metastasis of cancer, to a method for diagnosing cancer using the monoclonal antibody and to a cancer diagnosis kit comprising the monoclonal antibody.