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10 条记录 (耗时 0.019 秒)

    NANOPOSITIONING SUBSTRATE PREPARATION APPARATUS AND PREPARATION METHOD USING DIP PEN NANOLITHOGRAPHY WITH SINGLE OR MULTIPLE TIPS USING ATOMIC FORCE MICROSCOPE (AFM)
    5.
    发明公开
    NANOPOSITIONING SUBSTRATE PREPARATION APPARATUS AND PREPARATION METHOD USING DIP PEN NANOLITHOGRAPHY WITH SINGLE OR MULTIPLE TIPS USING ATOMIC FORCE MICROSCOPE (AFM) 有权
    用于制造纳米定位基底与个人或多片蘸笔纳米光刻设备和方法的方法使用核武器高倍显微镜

    公开(公告)号：EP2720040A2

    公开(公告)日：2014-04-16

    申请号：EP12801029.5

    申请日：2012-05-21

    申请人： Korea Research Institute of Bioscience and Biotechology

    发明人： HA, Tai-Hwan ,  PARK, Jee-Eun

    IPC分类号： G01N33/48 ,  G01Q60/24 ,  G01Q80/00 ,  B82B3/00

    CPC分类号： B05C11/00 ,  B05D5/00 ,  B81C99/0025 ,  B82Y10/00 ,  G01Q80/00 ,  G03F7/0002

    摘要： The present invention relates to dip pen nanolithography technique which is an imaging method using a atomic force microscope, and more specifically, to a preparation apparatus and a preparation method for a nanopositioning substrate of an ink system using dip pen nanolithography with a single or multiple tips. According to the present invention, with respect to the imaging method using the atomic force microscope, provided is the preparation apparatus and the preparation method for the nanopositioning substrate of the ink system using dip pen nanolithography, with single or multiple tips, comprising: a first ink storage portion and a second ink storage portion for coating a tip with an ink; a first washing portion and a second washing portion for washing the tip coated with an ink; a pattern carving portion for carving a tip on a substrate; an electrode connection portion for applying voltage; and a position checking portion for checking or determining the position of the coated tip on a micrometer-scale area, wherein the position checking portion is formed to check position through the change of a voltage-current, the extent of bending of an AFM tip with respect to voltage and an AFM image; and it is possible to increase the density of a biomaterial on the micrometer-scale area by integrating a large number of the biomaterial on the substrate by using the reproducibility of the atomic force microscope tip position.

    COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING EXTRACTS OF ARTOCARPUS ALTILIS FRUITS, LEAVES, OR STEMS, OR FRACTIONS THEREOF AS ACTIVE INGREDIENTS
    6.
    发明公开
    COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING EXTRACTS OF ARTOCARPUS ALTILIS FRUITS, LEAVES, OR STEMS, OR FRACTIONS THEREOF AS ACTIVE INGREDIENTS 有权
    组成预防和与提取物治疗癌症的FROM桂altilis果， - 下层或-STÄNGELN或其组为活动

    公开(公告)号：EP2889038A1

    公开(公告)日：2015-07-01

    申请号：EP13832476.9

    申请日：2013-07-26

    申请人： Korea Research Institute of Bioscience and Biotechology

    发明人： KWON, Byoung-Mog ,  HAN, Dong Cho ,  LEE, Joongku ,  JEON, Yoon-jeong ,  CHOI, Sang Ho

    IPC分类号： A61K36/60 ,  A61P35/00

    CPC分类号： A61K36/60

    摘要： The present invention relates to a pharmaceutical composition for preventing and treating cancer which comprises the extracts of Artocarpus altilis fruits, leaves, or stems, or the fractions thereof as active ingredients. The extracts of Artocarpus altilis fruits, leaves, or stems, or the fractions thereof, according to the present invention, suppress the activity of signal transducer and activator of transcription3 (STAT3) which plays an important role in the growth of a cancer cell line and in the immune function of the human body, and can thus be effectively used in the prevention and treatment of cancers such as colorectal cancer, stomach cancer, prostate cancer, breast cancer, renal cancer, liver cancer, brain tumor, lung cancer, uterine cancer, colorectal cancer, bladder cancer, or pancreatic cancer.

    摘要翻译： 本发明涉及一种药物组合物，用于预防和治疗癌症，其包括红桂altilis水果的提取物，叶，茎或或它们的级分作为活性成分。 桂altilis水果的提取物，叶，或茎，或其分数，雅丁到本发明中，抑制信号转导和transcription3（STAT3）的活化剂，其在重要的作用在癌细胞系的生长起到的活性和 在人体内的免疫功能，并因此可有效地用于预防和治疗癌症的使用：例如结肠直肠癌，胃癌，前列腺癌，乳腺癌，肾癌，肝癌，脑癌，肺癌，子宫癌 ，结肠直肠癌，膀胱癌或胰腺癌。

    NOVEL GENE DERIVED FROM MUD FLAT METAGENOME AND NOVEL PROTEIN OBTAINED THEREFROM SHOWING COACTIVITY OF PHOSPHOLIPASE AND LIPASE
    8.
    发明公开
    NOVEL GENE DERIVED FROM MUD FLAT METAGENOME AND NOVEL PROTEIN OBTAINED THEREFROM SHOWING COACTIVITY OF PHOSPHOLIPASE AND LIPASE 有权
    关于蛋白质大豆蛋白磷脂酶的消化不良蛋白酶

    公开(公告)号：EP2784160A1

    公开(公告)日：2014-10-01

    申请号：EP12850464.4

    申请日：2012-07-17

    申请人： Korea Research Institute of Bioscience and Biotechology

    发明人： YOON, Jung-Hoon ,  LEE, Mi Hwa ,  KANG, Chul Hyung ,  OH, Ki Hoon ,  OH, Tae Kwang

    IPC分类号： C12N15/55 ,  C07K14/195 ,  C12N15/63 ,  C12P21/00

    CPC分类号： C07K14/195 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/41 ,  C07K2319/43 ,  C07K2319/50 ,  C11D3/38627 ,  C12N9/20 ,  C12Y301/01003 ,  C12Y301/01032

    摘要： The present invention relates to a novel gene derived from a tidal flat metagenome, and a novel protein obtained therefrom showing the coactivity of phospholipase and lipase. Specifically, the novel gene isolated from the metagenome library of tidal flat sedimentsand the protein having phospholipase and lipase activities encoded from the novel gene: are expressed in a water-soluble form to be mass-producible; enable ultra high-purity protein to be obtained through single step purification using an Ni-NTA column; show good activity in the pH range of 5 ∼ 10; maintain good low temperature activity and stability up to a temperature of 3°C to 40°C; and have high resistance against various organic solvents. Therefore, the novel gene and the protein can be usefully used for various industrial fields such as the purification and conversion of oil and fat, bio-medicine, and fine chemistry.

    摘要翻译： 本发明涉及一种源自潮平型巨型细胞突变体的新基因，以及由此得到的新型蛋白质，显示出磷脂酶和脂肪酶的共同作用。 具体来说，从潮汐沉积物的宏基因组文库中分离出的新基因以及从新基因编码的具有磷脂酶和脂肪酶活性的蛋白质以水溶性形式表达，可以批量生产; 使用Ni-NTA柱通过单步纯化获得超高纯度蛋白质; 在5¼10的pH范围内表现出良好的活性; 保持良好的低温活性和稳定性，温度可达3°C至40°C; 对各种有机溶剂具有很高的抵抗力。 因此，新型基因和蛋白质可用于各种工业领域，如油脂的纯化和转化，生物医药和精细化学。

    NOVEL LOW-MOLECULE COMPOUND FOR PROMOTING PLURIPOTENT STEM CELL GENERATION, MAINTENANCE, AND PROLIFERATION, AND COMPOSITION AND CULTURING METHOD CONTAINING SAME
    9.
    发明公开
    NOVEL LOW-MOLECULE COMPOUND FOR PROMOTING PLURIPOTENT STEM CELL GENERATION, MAINTENANCE, AND PROLIFERATION, AND COMPOSITION AND CULTURING METHOD CONTAINING SAME 有权
    低分子量新组合鼓励生产，这种文化关怀和增殖的多能干细胞，组合物及方法

    公开(公告)号：EP2774918A1

    公开(公告)日：2014-09-10

    申请号：EP12877706.7

    申请日：2012-11-08

    申请人： Korea Research Institute of Bioscience and Biotechology

    发明人： CHO, Yee Sook ,  LEE, Kyeong ,  LEE, Jung Woon

    IPC分类号： C07D209/20 ,  C12N5/0735 ,  C12N5/02

    CPC分类号： C12N5/0696 ,  C07D209/18 ,  C07D209/20 ,  C07D209/24 ,  C07D405/12 ,  C12N5/0606 ,  C12N2500/02 ,  C12N2500/30 ,  C12N2501/115 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/09

    摘要： According to the present invention, when the novel low-molecular-weight compound RSC-133 is added in a culture process for producing reprogrammed pluripotent stem cells from human differentiated cells, it can increase the efficiency of reprogramming and can significantly reduce the time required for the induction of reprogramming. Particularly, the novel compound RSC-133 can substitute for c-Myc acting as both a reprogramming factor and an oncogenic factor, and it can effectively increase the efficiency of reprogramming in both normal oxygen culture conditions and hypoxic culture conditions. In addition, RSC-133 can inhibit the induction of aging occurring in the reprogramming process, exhibits the effect of promoting cell proliferation, and induces epigenetic activation to improve culture conditions for induction of reprogramming. The present invention will contribute to optimizing a process of producing induced pluripotent stem cells from a small amount of patient-specific somatic cells obtained from various sources, and thus it will significantly improve a process of developing clinically applicable personalized stem cell therapy agents and new drugs and will facilitate the practical use of these agents and drugs. In addition, the novel low-molecular-weight compound RSC-133 can provide a cell culture medium effective for maintaining the undifferentiated state of human embryonic stem cells that are typical pluripotent stem cells. The medium composition containing RSC-133 can effectively induce the proliferation of human embryonic stem cells in an undifferentiated state and can be effectively used for the development of a system for culturing large amounts of embryonic stem cells.