公开(公告)号：EP3882244A1

公开(公告)日：2021-09-22

申请号：EP21152125.7

申请日：2013-12-16

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  HAN, Soo Bong ,  LEE, Chong-Kyo ,  KIM, Hae Soo ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan ,  MALPANI, Yashwardhan Radhamohan ,  SHIN, Jin Soo

IPC分类号： C07D405/12 ,  C07D409/12 ,  A61K31/4025 ,  A61P31/12

摘要： The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.

公开(公告)号：EP4139290A1

公开(公告)日：2023-03-01

申请号：EP21721882.5

申请日：2021-04-20

申请人： Novartis AG ,  Katholieke Universiteit Leuven KU Leuven Research & Development ,  Korea Research Institute of Chemical Technology

发明人： NEYTS, Johan ,  POON, Daniel ,  PFISTER, Keith Bruce ,  JUNG, Young-Sik ,  HAN, Soo Bong ,  MALPANI, Yashwardhan R. ,  CHAKRASALI, Prashant ,  KIM, Chonsaeng ,  SHIN, Jin Soo ,  KIM, Hae Soo ,  LEE, Chong-Kyo ,  LEE, Sang-Ho

IPC分类号： C07D307/77 ,  A61P31/16 ,  A61K31/496

公开(公告)号：EP2933254A1

公开(公告)日：2015-10-21

申请号：EP13862055.4

申请日：2013-12-16

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven K.U. Leuven R&D

发明人： JUNG, Young Sik ,  HAN, Soo Bong ,  LEE, Chong-Kyo ,  KIM, Hae Soo ,  SHIN, Jin Soo ,  JOHAN, Neyts ,  HENDRIK, Jan Thibaut ,  MALPANI, Yashwardhan Radhamohan

IPC分类号： C07D405/12 ,  C07D409/12 ,  A61K31/4025 ,  A61P31/12

CPC分类号： C07D417/12 ,  C07D307/93 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12

摘要： The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.

摘要翻译： 本发明涉及一种新颖的化合物，药学上可接受的盐或其旋光异构体，涉及一种制备方法，以及一种用于病毒性疾病的预防或治疗的药物组合物包含相同的活性成分。 新型化合物雅丁到本发明不仅具有低的细胞毒性，但这样具有对细小核糖核酸病毒优异的抗病毒活性：如柯萨奇病毒，肠道病毒，艾柯病毒，脊髓灰质炎病毒和鼻病毒，并且因此可以有效地用作用于病毒的预防或治疗的药物组合物 疾病：如小儿麻痹症，急性出血性结膜炎，病毒性脑膜炎，手足口病，水疱病，A型肝炎，myitis，心肌炎，胰腺炎，糖尿病，流行性肌痛，脑炎，感冒，疱疹性咽峡炎，手足口 病，哮喘，慢性阻塞性肺病，肺炎，鼻窦感染，或中耳炎。

公开(公告)号：EP4139301A1

公开(公告)日：2023-03-01

申请号：EP21721039.2

申请日：2021-04-20

申请人： Novartis AG ,  Katholieke Universiteit Leuven KU Leuven Research & Development ,  Korea Research Institute of Chemical Technology

发明人： NEYTS, Johan ,  POON, Daniel ,  PFISTER, Keith Bruce ,  JUNG, Young-Sik ,  HAN, Soo Bong ,  MALPANI, Yashwardhan R. ,  CHAKRASALI, Prashant ,  BISWAS, Bishyajit Kumar ,  KIM, Chonsaeng ,  SHIN, Jin Soo ,  KIM, Hae Soo ,  LEE, Chong-Kyo

IPC分类号： C07D405/12 ,  C07D307/77 ,  A61P31/16 ,  A61K31/496

公开(公告)号：EP2044037A2

公开(公告)日：2009-04-08

申请号：EP07836229.0

申请日：2007-07-24

申请人： Gilead Sciences, Inc. ,  Korea Research Institute Of Chemical Technology

发明人： GUO, Hongyan ,  KIM, Choung U. ,  KIM, Hae Soo ,  LEE, Chong-Kyo ,  LEE, III Young ,  MITCHELL, Michael L. ,  SON, Jong, Chan ,  XU, Lianhong ,  KIRSCHBERG, Thorsten, A.

IPC分类号： C07D239/54

CPC分类号： C07D401/06 ,  C07D239/54 ,  C07D403/06 ,  C07D413/06

摘要： The invention is related to compounds of Formula (I), (II), or (III); or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.