公开(公告)号：EP3882244A1

公开(公告)日：2021-09-22

申请号：EP21152125.7

申请日：2013-12-16

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  HAN, Soo Bong ,  LEE, Chong-Kyo ,  KIM, Hae Soo ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan ,  MALPANI, Yashwardhan Radhamohan ,  SHIN, Jin Soo

IPC分类号： C07D405/12 ,  C07D409/12 ,  A61K31/4025 ,  A61P31/12

摘要： The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.

公开(公告)号：EP2722042A2

公开(公告)日：2014-04-23

申请号：EP12800577.4

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven, K.U. Leuven R&D

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  KIM, Hae Soo ,  JEONG, Hee Chun ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan ,  SHIN, Jin Soo

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/12 ,  A61P31/12

CPC分类号： C07D307/93 ,  C07C233/32 ,  C07D209/94 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07F9/65517

摘要： The present invention relates to a novel indanone derivative, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient for preventing or treating viral diseases. The indanone derivatives according to the present invention not only have low cyto-toxicity, but can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

摘要翻译： 本发明涉及一种新颖茚满酮衍生物，药学上可接受的盐或旋光异构体，对相同的制备方法，以及含有相同的用于预防或治疗病毒疾病的活性成分的药物组合物。 茚满酮衍生物gemäß到本发明不仅具有低CYTO-毒性，但由此可以证明可用作用于预防或治疗病毒性疾病的药物组合物：如：; 脊髓灰质炎病毒麻痹，急性出血性结膜炎，病毒性脑膜炎，手足口病，水疱病，A型肝炎，肌炎，心肌炎，胰腺炎，病毒性糖尿病，流行性肌痛，脑炎，流感，疱疹性咽峡，手足口病 ，哮喘，慢性阻塞性肺疾病，肺炎，鼻窦炎，中耳炎等，因为对小核糖核酸病毒优异的抗病毒活性：如柯萨奇病毒，肠道病毒，埃可病毒，脊髓灰质炎病毒，鼻病毒等，已经以实例阐述。

公开(公告)号：EP4360710A2

公开(公告)日：2024-05-01

申请号：EP23218086.9

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： A61P31/00

CPC分类号： C07C271/24 ,  C07C271/44 ,  C07C271/64 ,  C07C275/26 ,  C07C275/64 ,  C07C205/45 ,  C07C323/22 ,  C07C225/20 ,  C07C225/22 ,  C07C233/41 ,  C07C233/61 ,  C07C233/76 ,  C07C247/14 ,  C07C69/16 ,  C07C69/18 ,  C07C69/28 ,  C07C69/54 ,  C07C69/618 ,  C07C69/63 ,  C07C69/738 ,  C07C69/78 ,  C07C49/747 ,  C07C49/753 ,  C07D215/20 ,  C07D213/65 ,  C07C2601/0220170501 ,  C07C2602/0820170501 ,  C07D221/04 ,  A61P11/02 ,  A61P17/00 ,  A61P21/00 ,  A61P25/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P31/16 ,  A61P3/10 ,  A61P9/00 ,  Y02A50/30

摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

公开(公告)号：EP2722322A2

公开(公告)日：2014-04-23

申请号：EP12799827.6

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven, K.U. Leuven R&D

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C13/465 ,  A61K31/04 ,  A61K31/47 ,  A61P31/12

摘要： The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. The 1,3-dioxoindene derivatives of formula (1) according to the present invention have low cyto-toxicity, and can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

公开(公告)号：EP3597184A2

公开(公告)日：2020-01-22

申请号：EP19169080.9

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  KIM,, Hae Soo ,  JEONG, Hee Chun ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan ,  SHIN, Jin Soo

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/12 ,  A61P31/12 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D209/94 ,  C07D307/93

摘要： The present invention relates to a novel indanone derivative, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient for preventing or treating viral diseases. The indanone derivatives according to the present invention not only have low cyto-toxicity, but can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot- and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

公开(公告)号：EP2722322B1

公开(公告)日：2019-06-12

申请号：EP12799827.6

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven K.U. Leuven R&D

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  A61P31/12 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61K31/04 ,  A61K31/47

摘要： The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. The 1,3-dioxoindene derivatives of formula (1) according to the present invention have low cyto-toxicity, and can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

公开(公告)号：EP4139301A1

公开(公告)日：2023-03-01

申请号：EP21721039.2

申请日：2021-04-20

申请人： Novartis AG ,  Katholieke Universiteit Leuven KU Leuven Research & Development ,  Korea Research Institute of Chemical Technology

发明人： NEYTS, Johan ,  POON, Daniel ,  PFISTER, Keith Bruce ,  JUNG, Young-Sik ,  HAN, Soo Bong ,  MALPANI, Yashwardhan R. ,  CHAKRASALI, Prashant ,  BISWAS, Bishyajit Kumar ,  KIM, Chonsaeng ,  SHIN, Jin Soo ,  KIM, Hae Soo ,  LEE, Chong-Kyo

IPC分类号： C07D405/12 ,  C07D307/77 ,  A61P31/16 ,  A61K31/496

公开(公告)号：EP3597184A3

公开(公告)日：2020-04-22

申请号：EP19169080.9

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  KIM,, Hae Soo ,  JEONG, Hee Chun ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan ,  SHIN, Jin Soo

IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/12 ,  A61P31/12 ,  C07D405/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D209/94 ,  C07D307/93

摘要： The present invention relates to a novel indanone derivative, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient for preventing or treating viral diseases. The indanone derivatives according to the present invention not only have low cyto-toxicity, but can also demonstrate utility as pharmaceutical compositions for preventing or treating viral diseases such as:; polio, viral paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-mouth disease, blistering diseases, hepatitis A, myositis, myocarditis, pancreatitis, viral diabetes, epidemic myalgia, encephalitis, flu, herpes angina, foot- and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis, otitis media, and the like, since excellent antiviral activity against picornaviruses such as Coxsackie virus, enterovirus, echovirus, polio virus, rhinovirus, and the like, have been demonstrated.

公开(公告)号：EP4360710A3

公开(公告)日：2024-08-07

申请号：EP23218086.9

申请日：2012-06-18

申请人： Korea Research Institute of Chemical Technology ,  Katholieke Universiteit Leuven

发明人： JUNG, Young Sik ,  LEE, Chong Kgo ,  CHOI, Ihl Young ,  KIM, Hae Soo ,  KIM, Pil Ho ,  HAN, Soo Bong ,  NEYTS, Johan ,  THIBAUT, Hendrik Jan

IPC分类号： C07C69/16 ,  C07C69/54 ,  C07C271/24 ,  C07C205/45 ,  C07D213/65 ,  C07C225/20 ,  C07C233/32 ,  C07C247/14 ,  C07C49/747 ,  A61P31/12 ,  A61K31/04 ,  A61K31/47

CPC分类号： C07C271/24 ,  C07C271/44 ,  C07C271/64 ,  C07C275/26 ,  C07C275/64 ,  C07C205/45 ,  C07C323/22 ,  C07C225/20 ,  C07C225/22 ,  C07C233/41 ,  C07C233/61 ,  C07C233/76 ,  C07C247/14 ,  C07C69/16 ,  C07C69/18 ,  C07C69/28 ,  C07C69/54 ,  C07C69/618 ,  C07C69/63 ,  C07C69/738 ,  C07C69/78 ,  C07C49/747 ,  C07C49/753 ,  C07D215/20 ,  C07D213/65 ,  C07C2601/0220170501 ,  C07C2602/0820170501 ,  C07D221/04 ,  A61P11/02 ,  A61P17/00 ,  A61P21/00 ,  A61P25/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P31/16 ,  A61P3/10 ,  A61P9/00 ,  Y02A50/30

摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.

公开(公告)号：EP4139290A1

公开(公告)日：2023-03-01

申请号：EP21721882.5

申请日：2021-04-20

申请人： Novartis AG ,  Katholieke Universiteit Leuven KU Leuven Research & Development ,  Korea Research Institute of Chemical Technology

发明人： NEYTS, Johan ,  POON, Daniel ,  PFISTER, Keith Bruce ,  JUNG, Young-Sik ,  HAN, Soo Bong ,  MALPANI, Yashwardhan R. ,  CHAKRASALI, Prashant ,  KIM, Chonsaeng ,  SHIN, Jin Soo ,  KIM, Hae Soo ,  LEE, Chong-Kyo ,  LEE, Sang-Ho

IPC分类号： C07D307/77 ,  A61P31/16 ,  A61K31/496