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1.发明公开
公开(公告)号：EP3940000A1
公开(公告)日：2022-01-19
申请号：EP20770859.5
申请日：2020-03-13
申请人： Korea University Research and Business Foundation , Seoul National University R & DB Foundation
发明人： SEO, Hong Seog , LEE, Yong Jik , JEONG, Jae Min , LEE, Yun Sang , PARK, Ji Yong
摘要： A carrageenan derivative according to the present disclosure can quickly and easily detect and label the presence of inflammation-related macrophages and, particularly, can accurately and easily identify M1-type macrophages highly associated with early inflammation. In addition, the carrageenan derivative has advantages in that it can be produced easily, environmental pollution is minimized because a small amount of organic solvent is used, and initial cost is low.
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公开(公告)号：EP3851127A1
公开(公告)日：2021-07-21
申请号：EP19861156.8
申请日：2019-09-11
发明人： JEONG, Jae Min , KIM, Young Ju , LEE, Yun-Sang , PARK, Ji Yong
摘要： The present invention relates to a composition for detecting hydrogen sulfide or measuring a concentration of hydrogen sulfide, and a composition comprising same as an effective ingredient for diagnosing or imaging in vivo inflammation, tissues having hypoxic damage, or cancer. The composition for detecting hydrogen sulfide or measuring a concentration of hydrogen sulfide according to the present invention, which comprises the compound represented by formula 1 ( 99m Tc-alpha-hydroxy acid) having alpha-hydroxy acid labeled with 99m Tc, enables the detection or concentration measurement of hydrogen sulfide in in-vitro and in-vivo levels and, as such, can be advantageously used for detecting hydrogen sulfide and measuring a concentration of hydrogen sulfide and furthermore for discovering biological roles of hydrogen sulfide in vivo, especially, for detecting, imaging, and quantitatively measuring hydrogen sulfide in a disease selected from the group consisting of angiogenesis, inflammation, cancer, Alzheimer's disease, cardiovascular ischemia, and cerebrovascular ischemia, or in hypoxic tissues.
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