公开(公告)号：EP2098515A1

公开(公告)日：2009-09-09

申请号：EP07828095.5

申请日：2007-11-29

申请人： Kowa Company. Ltd.

发明人： MATSUDA, Takayuki ,  OKUDA, Ayumu ,  KOURA, Minoru ,  YAMAGUCHI, Yuki ,  KUROBUCHI, Sayaka ,  WATANABE, Yuuichirou ,  SHIBUYA, Kimiyuki

IPC分类号： C07D233/72 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/498 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00

CPC分类号： C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D235/02 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

摘要： There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caused by inflammatory cytokines, skin diseases such as allergic skin diseases, diabetes or Alzheimer's disease. The agonist is a carbinol derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供了可用作动脉硬化的预防和/或治疗剂的新型LXR 2激动剂; 动脉硬化，如糖尿病; 高脂血症; 高胆固醇血症; 脂质相关疾病; 由炎性细胞因子引起的炎性疾病，皮肤疾病如过敏性皮肤疾病，糖尿病或阿尔茨海默病。 激动剂是由以下通式（1）表示的甲醇衍生物或其盐或其溶剂合物。

公开(公告)号：EP2426113B1

公开(公告)日：2013-11-06

申请号：EP10769511.6

申请日：2010-04-28

申请人： Kowa Company, Ltd.

发明人： KOURA, Minoru ,  SUMIDA, Hisashi ,  MATSUDA, Takayuki ,  WATANABE, Yuichiro ,  ENOMOTO, Takashi ,  SHIBUYA, Kimiyuki ,  KUROBUCHI, Sayaka

IPC分类号： C07D233/86 ,  A61K31/4164 ,  A61K31/496 ,  A61K31/551 ,  A61P3/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D491/048 ,  C07D491/056 ,  A61K31/4166 ,  A61P3/10 ,  A61P9/10 ,  A61P17/00 ,  A61P25/28 ,  A61P29/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04

CPC分类号： C07D233/78 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D491/04

公开(公告)号：EP2098515B1

公开(公告)日：2012-02-08

申请号：EP07828095.5

申请日：2007-11-29

申请人： Kowa Company, Ltd.

发明人： MATSUDA, Takayuki ,  OKUDA, Ayumu ,  KOURA, Minoru ,  YAMAGUCHI, Yuki ,  KUROBUCHI, Sayaka ,  WATANABE, Yuichiro ,  SHIBUYA, Kimiyuki

IPC分类号： C07D233/72 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/498 ,  A61P1/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00

CPC分类号： C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D235/02 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

摘要： Disclosed is a novel LXRβ agonist which is useful as a prophylactic and/or therapeutic agent for arteriosclerosis including atherosclerosis and arteriosclerosis induced by diabetes, hyperlipemia, hypercholesterolemia, a fat-related disease, an inflammatory disease which is a disease induced by an inflammatory cytokine, a skin disease such as allergic skin disease, diabetes or Alzheimer's disease. Specifically disclosed is a carbinol derivative represented by the general formula (1), a salt thereof, or a solvate of the derivative or the salt.

公开(公告)号：EP2281817A1

公开(公告)日：2011-02-09

申请号：EP09754469.6

申请日：2009-05-29

申请人： Kowa Company, Ltd.

发明人： YAMAGUCHI, Yuki ,  KOURA, Minoru ,  KUROBUCHI, Sayaka ,  MATSUDA, Takayuki ,  OKUDA, Ayumu ,  SUMIDA, Hisashi ,  WATANABE, Yuichiro ,  ENOMOTO, Takashi ,  SHIBUYA, Kimiyuki

IPC分类号： C07D233/72 ,  A61K31/4166 ,  A61K31/4178 ,  A61K31/4355 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P17/00 ,  A61P25/28 ,  A61P29/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04

CPC分类号： C07D233/72 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D491/048

摘要： It is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.
It is a carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

摘要翻译： 提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXR 2激动剂; 动脉硬化，如糖尿病; 血脂异常; 高胆固醇血症; 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 它是由以下通式（I）表示的甲醇化合物或其盐或其溶剂合物。

公开(公告)号：EP2248811A1

公开(公告)日：2010-11-10

申请号：EP09715052.8

申请日：2009-02-27

申请人： Kowa Company, Ltd.

发明人： OKUDA, Ayumu ,  MATSUDA, Takayuki ,  MIURA, Toru ,  OZAWA, Hidefumi ,  TOSAKA, Ayako ,  YAMAZAKI, Koichi ,  YAMAGUCHI, Yuki ,  KUROBUCHI, Sayaka ,  WATANABE, Yuuichirou ,  SHIBUYA, Kimiyuki

IPC分类号： C07D405/12 ,  A61K31/4178 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： [Object]
It is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes;dyslipidemia; hypercholesterolemia; lipid-reflated diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： [目的]提供一种可用作动脉粥样硬化的预防和/或治疗剂的新型LXR 2激动剂; 动脉硬化，如糖尿病;血脂异常; 高胆固醇血症; 脂质反流疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 由下列通式（1）表示的2-氧代色烯衍生物或其盐或其溶剂合物。

公开(公告)号：EP2248811B1

公开(公告)日：2012-11-14

申请号：EP09715052.8

申请日：2009-02-27

申请人： Kowa Company, Ltd.

发明人： OKUDA, Ayumu ,  MATSUDA, Takayuki ,  MIURA, Toru ,  OZAWA, Hidefumi ,  TOSAKA, Ayako ,  YAMAZAKI, Koichi ,  YAMAGUCHI, Yuki ,  KUROBUCHI, Sayaka ,  WATANABE, Yuichiro ,  SHIBUYA, Kimiyuki

IPC分类号： C07D405/12 ,  A61K31/4178 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

公开(公告)号：EP2426113A1

公开(公告)日：2012-03-07

申请号：EP10769511.6

申请日：2010-04-28

申请人： Kowa Company, Ltd.

发明人： KOURA, Minoru ,  SUMIDA, Hisashi ,  MATSUDA, Takayuki ,  WATANABE, Yuichiro ,  ENOMOTO, Takashi ,  SHIBUYA, Kimiyuki ,  KUROBUCHI, Sayaka

IPC分类号： C07D233/86 ,  A61K31/4164 ,  A61K31/496 ,  A61K31/551 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P17/00 ,  A61P25/28 ,  A61P29/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D491/048 ,  C07D491/056

CPC分类号： C07D233/78 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D491/04

摘要： It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. It is a carbinol compound represented by the following general formula (I) or salt thereof, or their solvate:

(wherein, each V and W independently show N or C-R 7 ; each X and Y independently show CH 2 , C=O, SO 2 , etc.; Z shows CH or N; each R 1 , R 2 and R 7 independently show a hydrogen atom, C 1-8 alkyl group, etc.; R 3 shows C 1-8 alkyl group; R 4 shows an optionally substituted C 6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R 5 and R 6 show a hydrogen atom, etc.; L shows a C 1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

摘要翻译： 提供可用作动脉粥样硬化预防剂和/或治疗剂的新型LXRβ激动剂; 动脉硬化如由糖尿病引起的动脉硬化; 血脂异常; 高胆固醇血症; 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默氏病。 它是由下列通式（I）表示的甲醇化合物或其盐，或它们的溶剂化物：（其中V和W各自独立地表示N或C-R7;每个X和Y独立地表示CH2，C = O，SO2 Z表示CH或N; R 1，R 2和R 7各自独立地表示氢原子，C 1-8烷基等; R 3表示C 1-8烷基; R 4表示任选取代的C 6-10芳基或 任选取代的5至11元杂环基; R 5和R 6表示氢原子等; L表示任选被氧代基取代的C 1-8烷基链;并且n表示0至2的任何整数 。）

公开(公告)号：EP2272843A1

公开(公告)日：2011-01-12

申请号：EP09738629.6

申请日：2009-04-27

申请人： Kowa Company, Ltd.

发明人： KOURA, Minoru ,  OKUDA, Ayumu ,  MATSUDA, Takayuki ,  YAMAGUCHI, Yuki ,  SUMIDA, Hisashi ,  KUROBUCHI, Sayaka ,  WATANABE, Yuuichirou ,  ENOMOTO, Takashi ,  SHIBUYA, Kimiyuki

IPC分类号： C07D405/14 ,  A61K31/4709 ,  A61K31/498 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P17/00 ,  A61P25/28 ,  A61P29/00 ,  C07D401/12 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14

摘要： It is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. It is related to a quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 本发明提供可用作动脉粥样硬化的预防剂和/或治疗剂的新型LXRβ激动剂， 动脉硬化如由糖尿病引起的动脉硬化; 血脂异常; 高胆固醇血症; 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默氏病。 它涉及由下列通式（1）表示的喹啉化合物或其盐或其溶剂化物。

公开(公告)号：EP2264029A1

公开(公告)日：2010-12-22

申请号：EP09728330.3

申请日：2009-03-30

申请人： Kowa Company, Ltd.

发明人： OKUDA, Ayumu ,  MATSUDA, Takayuki ,  MIURA, Toru ,  YAMAZAKI, Koichi ,  YAMAGUCHI, Yuki ,  KOURA, Minoru ,  KUROBUCHI, Sayaka ,  WATANABE, Yuichiro ,  SHIBUYA, Kimiyuki

IPC分类号： C07D405/12 ,  A61K31/4178 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  C07D405/14

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

摘要： The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 目的是提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXR 2激动剂; 动脉硬化，如糖尿病; 血脂异常; 高胆固醇血症; 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 解决方法是由以下通式（1）表示的1,3-二氢异苯并呋喃衍生物或其盐或其溶剂合物。